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Therapeutic Efficacy of Chloroquine in Plasmodium vivax and the pvmdr1 Polymorphisms in the Republic of Korea Under Mass Chemoprophylaxis

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  • Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju, Korea; Konyang University, Myunggok Medical Research Institute, Daejeon, Korea; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea; Department of Preventive Medicine, The Armed Forces Medical Command, Sungnam, Korea; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

Chemoprophylaxis with hydroxychloroquine (HCQ) and primaquine has been used in the Republic of Korea (ROK) Army since 1997. It may facilitate the development of chloroquine (CQ)-resistant strains of Plasmodium vivax. We investigated the therapeutic efficacy of HCQ and the pvmdr1 gene polymorphisms in P. vivax. From June to September 2006, 102 soldiers with vivax malaria near the demilitarized zone in Gyeonggi-do, ROK, were enrolled in the study. We determined the status of compliance of chemoprophylaxis. In 85 patients, therapeutic efficacy was monitored 28 days after standard HCQ treatment; 66 (64.7%) of 102 malaria patients had taken all chemoprolaxis with HCQ. In all patients enrolled in the therapeutic efficacy monitoring, parasitemia had not been observed since 3 days after standard HCQ treatment. However, the ubiquitous presence of the F1076L mutation of the pvmdr1 was observed. There was no evidence that the F1076L mutation of pvmdr1 could contribute to failure of HCQ treatment.

Author Notes

*Address correspondence to June Myung Kim, Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-Dong, Seodaemun-Gu, Seoul 120-752, Republic of Korea. E-mail: jmkim@yuhs.ac

Financial support: This work was supported in part by Konyang University Myung Gok Research Fund of 2007.

Authors' addresses: Young Keun Kim, Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Kangwon-do, Republic of Korea, E-mail: amoxj@yonsei.ac.kr. Changsoo Kim, Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea, E-mail: preman@yuhs.ac. Inho Park, Chief of Professional Service, Armed Forces Seoul Hospital, Seoul, Republic of Korea, E-mail: park_in_ho@yahoo.co.kr. Hyo Youl Kim, Yonsei University, Wonju College of Medicine, Kangwon-do, Republic of Korea, E-mail: hyksos@yonsei.ac.kr. Jun Yong Choi and June Myung Kim, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea, E-mails: seran@yuhs.ac and jmkim@yuhs.ac.

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