Tumor Necrosis Factor-α and Mortality in Patients Infected with Vibrio vulnificus

Jun-Young Lee Department of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

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Dong-Min Kim Department of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

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Na Ra Yun Department of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

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Ganesh Prasad Neupane Department of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

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Sook-In Jung Department of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

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Kyung-Hwa Park Department of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

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Hee Chang Jang Department of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

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Chang Seop Lee Department of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

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Sun Hee Lee Department of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

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DOI:
https://doi.org/10.4269/ajtmh.2011.10-0310
Volume/Issue:
Volume 84: Issue 3
Page(s):
426–428
Restricted access
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Serum tumor necrosis factor-α (TNF-α) was evaluated in Vibrio vulnificus-infected patients at admission. The median TNF-α concentration in the non-survivor group was determined to be 261.0 pg/mL, in contrast to 69.5 pg/mL in the survivor group (P = 0.001). Hence, serum TNF-α concentration may potentially be an early predictor of the mortality in patients with Vibrio septicemia.

Author Notes

*Address correspondence to Dong-Min Kim, Department of Internal Medicine, Chosun University College of Medicine, 588 Seosuk-dong, Dong-gu, Gwangju, 501-717, Republic of Korea. E-mail: drongkim@chosun.ac.kr
†Jun-Young Lee and Sook-In Jung contributed equally to this work.

Authors' addresses: Jun-Young Lee, Department of Orthopaedic Surgery, Chosun University College of Medicine, Dong-Gu, Gwangju, Republic of Korea, E-mail: leejy88@chosun.ac.kr. Dong-Min Kim, Na-Ra Yun, and Ganesh Prasad Neupane, Department of Internal Medicine, Chosun University College of Medicine, Dong-Gu, Gwangju, Republic of Korea, E-mails: drongkim@chosun.ac.kr, shinenara@gmail.com, and neupaneganesh@yahoo.com. Sook-In Jung, Kyung-Hwa Park, and Hee Chang Jang, Department of Infectious Diseases, Chonnam National University Hospital, Dong-gu, Gwangju, Republic of Korea, E-mails: sijung@jnu.ac.kr, medkid@dreamwiz.com, and haroc153@naver.com. Chang Seop Lee, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Geumam-dong, Jeonju, Republic of Korea, E-mail: lcsmd@jbnu.ac.kr. Sun Hee Lee, Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea, E-mail: mdssampak@yahoo.co.kr.

Copyright:
©The American Society of Tropical Medicine and Hygiene 2011
Received:
31 May 2010
|
Accepted:
18 Nov 2010
|
Published Online:
04 Mar 2011
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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