Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
  • 1.

    Hlady WG, Klontz KC, 1996. The epidemiology of Vibrio infections in Florida, 1981–1993. J Infect Dis 173: 1176–1183.

  • 2.

    Bullen JJ, Spalding PB, Ward CG, Gutteridge JM, 1991. Hemochromatosis, iron, and septicemia caused by Vibrio vulnificus. Arch Intern Med 151: 1606–1609.

    • Search Google Scholar
    • Export Citation
  • 3.

    Simpson AJ, Smith MD, Weverling GJ, Suputtamongkol Y, Angus BJ, Chaowagul W, White NJ, van Deventer SJ, Prins JM, 2000. Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis. J Infect Dis 181: 621–625.

    • Search Google Scholar
    • Export Citation
  • 4.

    Waage A, Halstensen A, Espevik T, 1987. Association between tumor necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet 14: 355–57.

    • Search Google Scholar
    • Export Citation
  • 5.

    Hor LI, Chang YK, Chang CC, Lei HY, Ou JT, 2000. Mechanism of high susceptibility of iron-overloaded mouse to Vibrio vulnificus infection. Microbiol Immunol 44: 871–878.

    • Search Google Scholar
    • Export Citation
  • 6.

    Shin SH, Shin DH, Ryu PY, Chung SS, Rhee JH, 2002. Proinflammatory cytokine profile in Vibrio vulnificus septicemic patients' sera. FEMS Immunol Med Microbiol 33: 133–138.

    • Search Google Scholar
    • Export Citation
  • 7.

    Kim HS, Kim DM, Neupane GP, Lee YM, Yang NW, Jang SJ, Jung SI, Park KH, Park HR, Lee CS, Lee SH, 2008. Comparison of conventional, nested, and real-time PCR assays for rapid and accurate detection of Vibrio vulnificus. J Clin Microbiol 46: 2992–2998.

    • Search Google Scholar
    • Export Citation
  • 8.

    Kim DM, Lee YM, Back JH, Yang TY, Lee JH, Song HJ, Shim SK, Park MY, 2010. A serosurvey of Orientia tsutsugamushi from patients with scrub typhus. Clin Microbiol Infect 16: 447–451.

    • Search Google Scholar
    • Export Citation
  • 9.

    Kim DM, Lym Y, Jang SJ, Han H, Kim YG, Chung CH, Hong SP, 2005. In vitro efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus. Antimicrob Agents Chemother 49: 3489–3491.

    • Search Google Scholar
    • Export Citation
  • 10.

    Powell JL, Wright AC, Wasserman SS, Hone DM, Morris JG Jr, 1997. Release of tumor necrosis factor alpha in response to Vibrio vulnificus capsular polysaccharide in in vivo and in vitro models. Infect Immun 65: 3713–3718.

    • Search Google Scholar
    • Export Citation
  • 11.

    Espat NJ, Auffenberg T, Abouhamze A, Baumhofer J, Moldawer LL, Howard RJ, 1996. A role for tumor necrosis factor-alpha in the increased mortality associated with Vibrio vulnificus infection in the presence of hepatic dysfunction. Ann Surg 223: 428–433.

    • Search Google Scholar
    • Export Citation
  • 12.

    Kumar A, Haery C, Paladugu B, Kumar A, Symeoneides S, Taiberg L, Osman J, Trenholme G, Opal SM, Goldfarb R, Parrillo JE, 2006. The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: association with serum lactate and inflammatory cytokine levels. J Infect Dis 193: 251–258.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 287 83 2
PDF Downloads 44 10 2
 
 
 
 
 
 
 
 
 
 
 

Tumor Necrosis Factor-α and Mortality in Patients Infected with Vibrio vulnificus

Jun-Young LeeDepartment of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

Search for other papers by Jun-Young Lee in
Current site
Google Scholar
PubMedClose
,
Dong-Min KimDepartment of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

Search for other papers by Dong-Min Kim in
Current site
Google Scholar
PubMedClose
,
Na Ra YunDepartment of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

Search for other papers by Na Ra Yun in
Current site
Google Scholar
PubMedClose
,
Ganesh Prasad NeupaneDepartment of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

Search for other papers by Ganesh Prasad Neupane in
Current site
Google Scholar
PubMedClose
,
Sook-In JungDepartment of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

Search for other papers by Sook-In Jung in
Current site
Google Scholar
PubMedClose
,
Kyung-Hwa ParkDepartment of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

Search for other papers by Kyung-Hwa Park in
Current site
Google Scholar
PubMedClose
,
Hee Chang JangDepartment of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

Search for other papers by Hee Chang Jang in
Current site
Google Scholar
PubMedClose
,
Chang Seop LeeDepartment of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

Search for other papers by Chang Seop Lee in
Current site
Google Scholar
PubMedClose
, and
Sun Hee LeeDepartment of Orthopaedic Surgery, School of Medicine, Chosun University, Gwangju, Republic of Korea; Division of Infectious Disease, Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwang-ju, Republic of Korea; Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea; Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea

Search for other papers by Sun Hee Lee in
Current site
Google Scholar
PubMedClose
View More View Less
DOI:
https://doi.org/10.4269/ajtmh.2011.10-0310
Volume/Issue:
Volume 84: Issue 3
Page(s):
426–428
Restricted access
Get Permissions

Serum tumor necrosis factor-α (TNF-α) was evaluated in Vibrio vulnificus-infected patients at admission. The median TNF-α concentration in the non-survivor group was determined to be 261.0 pg/mL, in contrast to 69.5 pg/mL in the survivor group (P = 0.001). Hence, serum TNF-α concentration may potentially be an early predictor of the mortality in patients with Vibrio septicemia.

Author Notes

*Address correspondence to Dong-Min Kim, Department of Internal Medicine, Chosun University College of Medicine, 588 Seosuk-dong, Dong-gu, Gwangju, 501-717, Republic of Korea. E-mail: drongkim@chosun.ac.kr
†Jun-Young Lee and Sook-In Jung contributed equally to this work.

Authors' addresses: Jun-Young Lee, Department of Orthopaedic Surgery, Chosun University College of Medicine, Dong-Gu, Gwangju, Republic of Korea, E-mail: leejy88@chosun.ac.kr. Dong-Min Kim, Na-Ra Yun, and Ganesh Prasad Neupane, Department of Internal Medicine, Chosun University College of Medicine, Dong-Gu, Gwangju, Republic of Korea, E-mails: drongkim@chosun.ac.kr, shinenara@gmail.com, and neupaneganesh@yahoo.com. Sook-In Jung, Kyung-Hwa Park, and Hee Chang Jang, Department of Infectious Diseases, Chonnam National University Hospital, Dong-gu, Gwangju, Republic of Korea, E-mails: sijung@jnu.ac.kr, medkid@dreamwiz.com, and haroc153@naver.com. Chang Seop Lee, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Geumam-dong, Jeonju, Republic of Korea, E-mail: lcsmd@jbnu.ac.kr. Sun Hee Lee, Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, South Korea, E-mail: mdssampak@yahoo.co.kr.

Copyright:
©The American Society of Tropical Medicine and Hygiene 2011
Received:
31 May 2010
|
Accepted:
18 Nov 2010
|
Published Online:
04 Mar 2011
Save