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Comparison of Major Immunoglobulins Intrathecal Synthesis Patterns in Ecuadorian and Cuban Patients with Angiostrongyliasis

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  • Laboratorio Central de Líquido Cefalorraquídeo (LABCEL), Facultad de Ciencias Médicas Dr. Miguel Enríquez, Universidad de Ciencias Médicas de La Habana, Cuba; Dirección de Control y Mejoramiento de la Salud Pública, Ministerio de Salud Pública, Quito, Ecuador; Departamento de Parasitología, Instituto Nacional de Higiene Dr. Leopoldo Izquieta Perez, Guayaquil, Ecuador; Servicio de Neurología, Hospital Eugenio Espejo, Quito, Ecuador

Angiostrongylus cantonensis meningitis was first reported in Cuba in 1981, and it was recently reported in South America. The aim of this paper is to evaluate the intrathecal immunoglobulin synthesis patterns from Cuba's and Ecuador's patients with angiostrongyliasis; 8 Ecuadorian patients from two different outbreaks and 28 Cuban patients were studied. Simultaneous blood and cerebrospinal fluid simples were taken. Immunoglobulin (Ig) A, IgM, IgG, and albumin were quantified by radial immunodiffusion. Corresponding Reibergrams were applied. A three-Ig pattern was the most frequent in the two groups, but IgM was presented in all Ecuadorian young mature patients; however, in the Cuban children, only 12 of 28 patients had intrathecal IgM, but about 90% had an IgA and IgG synthesis at time of later puncture. This indicates that, with a larger amount of parasites ingested, clinical symptoms are more severe, and a higher frequency of intrathecal IgM synthesis could be observed. This is discussed as a similarity with the intrathecal IgM synthesis in African trypanosomiasis.

Author Notes

*Address correspondence to Alberto Juan Dorta-Contreras, Central Laboratory of Cerebrospinal Fluid, Faculty of Medical Sciences Dr. Miguel Enriquez, Superior Institute of Medical Sciences, Havana, Cuba. E-mail: adorta@infomed.sld.cu

Authors' addresses: Bárbara Padilla-Docal, Alberto J. Dorta-Contreras, María Esther Magraner-Tarrau, and Raisa Bu-Coifiu-Fanego, Laboratorio Central de Líquido Cefalorraquídeo (LABCEL), Facultad de Ciencias Médicas Dr. Miguel Enríquez, Universidad de Ciencias Médicas de La Habana, Cuba, E-mails: barbara.padilla@infomed.sld.cu, adorta@infomed.sld.cu, mariae.magraner@infomed.sld.cu, and raisabu@infomed.sld.cu. Juan M. Moreira, Dirección de Control y Mejoramiento de la Salud Pública, Ministerio de Salud Pública, Quito, Ecuador, E-mail: jmoreira@msp.gov.ec. Luiggi Martini-Robles and Jenny Muzzio-Aroca, Departamento de Parasitología, Instituto Nacional de Higiene, Dr. Leopoldo Izquieta Perez, Guayaquil, Ecuador, E-mails: luiggimartini8@hotmail.com and jennymuzzio@yahoo.com. Fernando Alarcón, Servicio de Neurología, Hospital Eugenio Espejo, Quito, Ecuador, E-mail: falarcn2000@hotmail.com.

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