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Malaria infection induces antibodies capable of suppressing the infectivity of gametocytes and gametes, however, little is known about the duration of the antibody response, the parasite specificity, and the role of complement. We report the analyses of the transmission-blocking (TB) activity of sera collected from 105 Plasmodium vivax-infected and 44 non-infected individuals from a malaria endemic region of Colombia, using a membrane feeding assay in Anopheles albimanus mosquitoes. In infected donors we found that TB activity was antibody dose dependent (35%), lasted for 2–4 months after infection, and in 70% of the cases different P. vivax wild isolates displayed differential susceptibility to blocking antibodies. Additionally, in a number of assays TB was complement-dependent. Twenty-seven percent of non-infected individuals presented TB activity that correlated with antibody titers. Studies here provide preliminary data on factors of great importance for further work on the development of TB vaccines.
Financial support: This work was supported by the National Institute of Allergy and Infectious Diseases through Tropical Medicine Research Centers NIAID/TMRC grant no. 49486 and through an International Center of Excellence for Malaria Research NIAID/ICEMR grant no U 19AI089702, the Instituto Colombiano para el Desarrollo de la Ciencia y Tecnología ‘Francisco José de Caldas' COLCIENCIAS grant no. 6124-05-17594, and the Ministry for Social Protection/Colciencias grant no. 2304-04-19524. John Beier was partially supported by the Abess Center for Ecosystem Science and Policy, University of Miami.
Authors' addresses: Myriam Arévalo-Herrera, Yezid Solarte, and Sócrates Herrera, Instituto de Inmunología, Edificio de Microbiología, Facultad de Salud, Universidad del Valle and Malaria Vaccine and Drug Development Center, Cali, Colombia, E-mails: firstname.lastname@example.org, email@example.com, and firstname.lastname@example.org. Leonardo Rocha and Diego Álvarez, Malaria Vaccine and Drug Development Center, Cali, Colombia, E-mails: email@example.com and firstname.lastname@example.org. John C. Beier, Department of Epidemiology and Public Health, Miller School of Medicine, Clinical Research Building, Miami, FL, E-mail: email@example.com.
Reprint requests: Sócrates Herrera, Malaria Vaccine and Drug Development Center, Carrera 37 - 2Bis No. 5E - 08, Cali, Colombia, E-mail: firstname.lastname@example.org.