• 1.

    Hotez P, Fenwick A, Savioli L, Molyneux D, 2009. Rescuing the bottom billion through control of neglected tropical diseases. Lancet 373: 15701575.

    • Search Google Scholar
    • Export Citation
  • 2.

    Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Sachs SE, Sachs J, 2006. Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, Tuberculosis, and Malaria. PLoS Med 3: e102.

    • Search Google Scholar
    • Export Citation
  • 3.

    WHO, 2006. Preventive Chemotherapy in Human Helminthiasis. Coordinated Use of Antihelminthic Drugs in Control Interventions: A Manual for Health Professionals and Programme Managers. Available at: http://www.who.int/neglected_diseases/preventive_chemotherapy/pct_manual/en/index.html. Accessed October 29, 2009.

    • Search Google Scholar
    • Export Citation
  • 4.

    Liese B, Rosenberg M, Schratz A, 2010. Programmes, partnerships, and governance for elimination and control of neglected tropical diseases. Lancet 375: 6776.

    • Search Google Scholar
    • Export Citation
  • 5.

    Brady MA, Hooper PJ, Ottesen EA, 2006. Projected benefits from integrating NTD programmes in Sub-Saharan Africa. Trends Parasitol 22: 285291.

    • Search Google Scholar
    • Export Citation
  • 6.

    Garba A, Touré S, Dembelé R, Boisier P, Tohon Z, Bosqué-Oliva E, Koukounari A, Fenwick A, 2009. Present and future schistosomiasis control activities with support from the Schistosomiasis Control Initiative in west Africa. Parasitology 136: 17311737.

    • Search Google Scholar
    • Export Citation
  • 7.

    Lammie P, Fenwick A, Utzinger J, 2006. A blueprint for success: integration of neglected tropical disease control programmes. Trends Parasitol 22: 313321.

    • Search Google Scholar
    • Export Citation
  • 8.

    Richards FJ, Eigege A, Miri E, Jinadu M, Hopkins D, 2006. Integration of mass drug administration programmes in Nigeria: the challenge of schistosomiasis. Bull World Health Organ 84: 673676.

    • Search Google Scholar
    • Export Citation
  • 9.

    United States, 2005. Congressional House, 2006. Foreign Operations, Export Financing, and Related Programs Appropriations Act. 109th Congress First session. HR 3057. Washington, DC: U.S. Government Printing Office.

    • Search Google Scholar
    • Export Citation
  • 10.

    Leading Global Health Organizations Receive $46.7 Million from Gates Foundation to Integrate Programs Fighting Neglected Tropical Diseases. Bill & Melinda Gates Foundation. December 19, 2006. Available at: http://www.gatesfoundation.org/press-releases/Pages/neglected-tropical-diseases-061219.aspx. Accessed July 12, 2010.

    • Search Google Scholar
    • Export Citation
  • 11.

    Gustavsen K, Bradley M, Wright A, 2009. GlaxoSmithKline and Merck: private-sector collaboration for the elimination of lymphatic filariasis. Ann Trop Med Parasitol 103 (Suppl 1): S11S15.

    • Search Google Scholar
    • Export Citation
  • 12.

    Knirsch C, 2007. Trachoma: ancient scourge, disease elimination, and future research. Curr Infect Dis Rep 9: 2128.

  • 13.

    Thylefors B, 2008. The Mectizan Donation Program (MDP). Ann Trop Med Parasitol 102 (Suppl 1): 3944.

  • 14.

    Goldman AS, Guisinger VH, Aikins M, Amarillo ML, Belizario VY, Garshong B, Gyapong J, Kabali C, Kamal HA, Kanjilal S, Kyelem D, Lizardo J, Malecela M, Mubyazi G, Nitiema PA, Ramzy RM, Streit TG, Wallace A, Brady MA, Rheingans R, Ottesen EA, Haddix AC, 2007. National mass drug administration costs for lymphatic filariasis elimination. PLoS Negl Trop Dis 1: e67.

    • Search Google Scholar
    • Export Citation
  • 15.

    Grépin K, Reich M, 2008. Conceptualizing integration: a framework for analysis applied to neglected tropical disease control partnerships. PLoS Negl Trop Dis 2: e174.

    • Search Google Scholar
    • Export Citation
  • 16.

    Chu BK, Hooper PJ, Bradley MH, McFarland DA, Ottesen EA, 2010. The economic benefits resulting from the first 8 years of the Global Programme to Eliminate Lymphatic Filariasis (2000–2007). PLoS Negl Trop Dis 4: e708.

    • Search Google Scholar
    • Export Citation
  • 17.

    Ottesen E, Hooper P, Bradley M, Biswas G, 2008. The global programme to eliminate lymphatic filariasis: health impact after 8 years. PLoS Negl Trop Dis 2: e317.

    • Search Google Scholar
    • Export Citation
  • 18.

    Diawara L, Traoré M, Badji A, Bissan Y, Doumbia K, Goita S, Konaté L, Mounkoro K, Sarr M, Seck A, Toé L, Tourée S, Remme J, 2009. Feasibility of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: first evidence from studies in Mali and Senegal. PLoS Negl Trop Dis 3: e497.

    • Search Google Scholar
    • Export Citation
  • 19.

    Sauerbrey M, 2008. The Onchocerciasis Elimination Program for the Americas (OEPA). Ann Trop Med Parasitol 102 (Suppl 1): 2529.

  • 20.

    Utzinger J, Raso G, Brooker S, De Savigny D, Tanner M, Ornbjerg N, Singer B, N'goran E, 2009. Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution. Parasitology 136: 18591874.

    • Search Google Scholar
    • Export Citation
  • 21.

    Gyapong J, Gyapong M, Yellu N, Anakwah K, Amofah G, Bockarie M, Adjei S, 2010. Integration of control of neglected tropical diseases into health-care systems: challenges and opportunities. Lancet 375: 160165.

    • Search Google Scholar
    • Export Citation

 

 

 

 

Integrated Implementation of Programs Targeting Neglected Tropical Diseases through Preventive Chemotherapy: Proving the Feasibility at National Scale

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  • RTI International, Washington, District of Columbia; United States Agency for International Development, Washington, District of Columbia; Department of International Health, School of Nursing and Health Sciences, Georgetown University, Washington, District of Columbia; Liverpool Associates in Tropical Health, Washington, District of Columbia

In 2006, the United States Agency for International Development established the Neglected Tropical Disease (NTD) Control Program to facilitate integration of national programs targeting elimination or control of lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis and blinding trachoma. By the end of year 3, 12 countries were supported by this program that focused first on disease mapping where needed, and then on initiating or expanding disease-specific programs in a coordinated/integrated fashion. The number of persons reached each year increased progressively, with a cumulative total during the first three years of 98 million persons receiving 222 million treatments with donated drugs valued at more than $1.4 billion. Geographic coverage increased substantially for all these infections, and the program has supported training of more than 220,000 persons to implement the programs. This current experience of the NTD Control Program demonstrates clearly that an integrated approach to control or eliminate these five neglected diseases can be effective at full national scale.

Author Notes

*Address correspondence to Kathryn L. Zoerhoff, Monitoring and Evaluation Associate, Neglected Tropical Disease Control Program, RTI International, 805 15th Street NW, Suite 601, Washington, DC 20005-2207. E-mail: kzoerhoff@rti.org

Financial support: This study and the NTD Control Program were supported by the United States Agency for International Development.

Authors' addresses: Mary Linehan, Kathryn L. Zoerhoff, and Eric A. Ottesen, Neglected Tropical Disease Control Program, RTI International, 805 15th Street NW, Suite 601, Washington, DC 20005-2207, E-mails: melinehan@rti.org, kzoerhoff@rti.org, eottesen@taskforce.org, and eottesen@rti.org. Christy Hanson, Infectious Disease Division, U.S. Agency for International Development, 1300 Pennsylvania Avenue NW, 3.7.16, Third Floor, Ronald Reagan Building, Washington, DC 20523, E-mail: chanson@usaid.gov. Angela Weaver, U.S. Agency for International Development, 1300 Pennsylvania Avenue NW, 3.07-27, Third Floor, Ronald Reagan Building, Washington, DC 20523, E-mail: aweaver@usaid.gov. Margaret Baker, Department of International Health, School of Nursing and Health Sciences, Georgetown University, 3700 Reservoir Road NW, Washington, DC 20057-1107, E-mail: mcb93@georgetown.edu. Achille Kabore, Neglected Tropical Disease Control Program, Liverpool Associates in Tropical Health, 805 15th Street, NW Suite 601, Washington, DC 20005-2207, E-mail: akabore@pti.org. Dieudonne Sankara, HTM/NTD/PCT/WHO-HQ, World Health Organization, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland, E-mail: sankarad@who.int. Scott Torres, Indoor Residual Spraying for Malaria Program, RTI International, Mayfair Suites, Second Floor, Parklands Road, PO Box 1181-00621, Nairobi, Kenya, E-mail: storres@rti.org.

Reprint requests: Neglected Tropical Disease Control Program, RTI International, 805 15th Street NW, Suite 601, Washington, DC 20005-2207.

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