Authors:
, , , , , , and
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Pediatric Dengue Vaccine Initiative, 2009. Global Burden of Dengue. Available at: http://www.pdvi.org/about_dengue/GBD.asp.
-
2.
Swaminathan S, Khanna N, 2009. Dengue: recent advances in biology and current status of translational research. Curr Mol Med 9: 152–173.
-
3.
Webster DP, Farrar J, Rowland-Jones S, 2009. Progress towards a dengue vaccine. Lancet Infect Dis 9: 678–687.
-
4.
Halstead SB, Voulgaropoulos EM, Tien NH, Udomsakdi S, 1965. Dengue hemorrhagic fever in South Vietnam: report of the 1963 outbreak. Am J Trop Med Hyg 14: 819–830.
-
5.
Halstead SB, 1997. Epidemiology of dengue and dengue hemorrhagic fever. Gubler DJ, Kuno G, eds. Dengue and Dengue Hemorrhagic Fever. Oxon, UK: CABI Publishing.
-
6.
Ha DQ, Tien NT, Huong VT, Loan HT, Thang CM, 2000. Dengue epidemic in southern Vietnam, 1998. Emerg Infect Dis 6: 422–425.
-
7.
Cummings DA, Iamsirithaworn S, Lessler JT, McDermott A, Prasanthong R, Nisalak A, Jarman RG, Burke DS, Gibbons RV, 2009. The impact of the demographic transition on dengue in Thailand: insights from a statistical analysis and mathematical modeling. PLoS Med 6: e1000139.
-
8.
Statistical Office of Ho Chi Minh City, 2009. Available at: http://www.pso.hochiminhcity.gov.vn/.
-
9.
World Health Organization, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control, 2nd ed. Geneva, Switzerland: World Health Organization.
-
10.
Simmons CP, Popper S, Dolocek C, Chau TN, Griffiths M, Dung NT, Long TH, Hoang DM, Chau NV, Thao le TT, Hien TT, Relman DA, Farrar J, 2007. Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever. J Infect Dis 195: 1097–1107.
-
11.
Vu TT, Holmes EC, Duong V, Nguyen TQ, Tran TH, Quail M, Churcher C, Parkhill J, Cardosa J, Farrar J, Wills B, Lennon NJ, Birren BW, Buchy P, Henn MR, Simmons CP, 2010. Emergence of the Asian 1 genotype of dengue virus serotype 2 in Viet Nam: in vivo fitness advantage and lineage replacement in South-East Asia. PLoS Negl Trop Dis 4: e757.
-
12.
Egger JR, Ooi EE, Kelly DW, Woolhouse ME, Davies CR, Coleman PG, 2008. Reconstructing historical changes in the force of infection of dengue fever in Singapore: implications for surveillance and control. Bull World Health Organ 86: 187–196.
-
13.
Guzman MG, Kouri G, Bravo J, Valdes L, Vazquez S, Halstead SB, 2002. Effect of age on outcome of secondary dengue 2 infections. Int J Infect Dis 6: 118–124.
-
14.
General Statistics Office of Vietnam, 2006. Household Living Standards Survey. Available at: http://www.gso.gov.vn/default_en.aspx?tabid=483&idmid=4&ItemID=8301.
-
15.
Chuang VW, Wong TY, Leung YH, Ma ES, Law YL, Tsang OT, Chan KM, Tsang IH, Que TL, Yung RW, Liu SH, 2008. Review of dengue fever cases in Hong Kong during 1998 to 2005. Hong Kong Med J 14: 170–177.
-
16.
Hammond SN, Balmaseda A, Perez L, Tellez Y, Saborio SI, Mercado JC, Videa E, Rodriguez Y, Perez MA, Cuadra R, Solano S, Rocha J, Idiaquez W, Gonzalez A, Harris E, 2005. Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua. Am J Trop Med Hyg 73: 1063–1070.
-
17.
Tantracheewathorn T, Tantracheewathorn S, 2007. Risk factors of dengue shock syndrome in children. J Med Assoc Thai 90: 272–277.
-
18.
Wang CC, Lee IK, Su MC, Lin HI, Huang YC, Liu SF, Wu CC, Lin MC, 2009. Differences in clinical and laboratory characteristics and disease severity between children and adults with dengue virus infection in Taiwan, 2002. Trans R Soc Trop Med Hyg 103: 871–877.
-
19.
Wichmann O, Hongsiriwon S, Bowonwatanuwong C, Chotivanich K, Sukthana Y, Pukrittayakamee S, 2004. Risk factors and clinical features associated with severe dengue infection in adults and children during the 2001 epidemic in Chonburi, Thailand. Trop Med Int Health 9: 1022–1029.
-
20.
Hon KL, Nelson EA, 2006. Gender disparity in paediatric hospital admissions. Ann Acad Med Singapore 35: 882–888.
-
21.
Halstead SB, Nimmannitya S, Cohen SN, 1970. Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. Yale J Biol Med 42: 311–328.
-
22.
Kabra SK, Jain Y, Pandey RM, Madhulika, Singhal T, Tripathi P, Broor S, Seth P, Seth V, 1999. Dengue haemorrhagic fever in children in the 1996 Delhi epidemic. Trans R Soc Trop Med Hyg 93: 294–298.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2671 | 1761 | 308 |
| Full Text Views | 954 | 22 | 5 |
| PDF Downloads | 605 | 33 | 7 |
Epidemiological Factors Associated with Dengue Shock Syndrome and Mortality in Hospitalized Dengue Patients in Ho Chi Minh City, Vietnam
Katherine L. Anders
Katherine L. Anders
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Department of Dengue Haemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam
Search for other papers by Katherine L. Anders in
Current site
Google Scholar
PubMed
Search for other papers by Katherine L. Anders in
Current site
Google Scholar
PubMed
Nguyen Minh Nguyet
Nguyen Minh Nguyet
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Department of Dengue Haemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam
Search for other papers by Nguyen Minh Nguyet in
Current site
Google Scholar
PubMed
Search for other papers by Nguyen Minh Nguyet in
Current site
Google Scholar
PubMed
Nguyen Van Vinh Chau
Nguyen Van Vinh Chau
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Department of Dengue Haemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam
Search for other papers by Nguyen Van Vinh Chau in
Current site
Google Scholar
PubMed
Search for other papers by Nguyen Van Vinh Chau in
Current site
Google Scholar
PubMed
Nguyen Thanh Hung
Nguyen Thanh Hung
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Department of Dengue Haemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam
Search for other papers by Nguyen Thanh Hung in
Current site
Google Scholar
PubMed
Search for other papers by Nguyen Thanh Hung in
Current site
Google Scholar
PubMed
Tran Thi Thuy
Tran Thi Thuy
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Department of Dengue Haemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam
Search for other papers by Tran Thi Thuy in
Current site
Google Scholar
PubMed
Search for other papers by Tran Thi Thuy in
Current site
Google Scholar
PubMed
Le Bich Lien
Le Bich Lien
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Department of Dengue Haemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam
Search for other papers by Le Bich Lien in
Current site
Google Scholar
PubMed
Search for other papers by Le Bich Lien in
Current site
Google Scholar
PubMed
Jeremy Farrar
Jeremy Farrar
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Department of Dengue Haemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam
Search for other papers by Jeremy Farrar in
Current site
Google Scholar
PubMed
Search for other papers by Jeremy Farrar in
Current site
Google Scholar
PubMed
Bridget Wills
Bridget Wills
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Department of Dengue Haemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam
Search for other papers by Bridget Wills in
Current site
Google Scholar
PubMed
Search for other papers by Bridget Wills in
Current site
Google Scholar
PubMed
Tran Tinh Hien
Tran Tinh Hien
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Department of Dengue Haemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam
Search for other papers by Tran Tinh Hien in
Current site
Google Scholar
PubMed
Search for other papers by Tran Tinh Hien in
Current site
Google Scholar
PubMed
Cameron P. Simmons
Cameron P. Simmons
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Department of Dengue Haemorrhagic Fever, Children's Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Infectious Diseases, Children's Hospital No. 2, Ho Chi Minh City, Vietnam
Search for other papers by Cameron P. Simmons in
Current site
Google Scholar
PubMed
Search for other papers by Cameron P. Simmons in
Current site
Google Scholar
PubMed
Understanding trends in dengue disease burden and risk factors for severe disease can inform health service allocation, clinical management, and planning for vaccines and therapeutics. Dengue admissions at three tertiary hospitals in Ho Chi Minh City, Vietnam, increased between 1996 and 2009, peaking at 22,860 in 2008. Children aged 6–10 years had highest risk of dengue shock syndrome (DSS); however, mortality was highest in younger children and decreased with increasing age (odds ratio [OR] = 0.52, 95% confidence interval [CI] = 0.36–0.75 in 6- to 10- year-old children and OR = 0.27, 95% CI = 0.16–0.44 in 11- to 15-year-old children compared with 1- to 5-year-old children). Males were overrepresented among dengue cases; however, girls had higher risk of DSS (OR = 1.19, 95% CI = 1.14–1.24) and death (OR = 1.57, 95% CI = 1.14–2.17). Young children with dengue had greatest risk of death and should be targeted in dengue vaccine and drug trials. The increased risk of severe outcomes in girls warrants further attention in studies of pathogenesis, health-seeking behavior, and clinical care.
Author Notes
Financial support: This study was supported by the Wellcome Trust.
Authors' addresses: Katherine L. Anders, Nguyen Minh Nguyet, Jeremy Farrar, Bridget Wills, Tran Tinh Hien, and Cameron P. Simmons, Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, E-mails: kanders@oucru.org, nguyetnm@oucru.org, jfarrar@oucru.org, bwills@oucru.org, hientt@oucru.org, and csimmons@oucru.org. Nguyen Van Vinh Chau, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, E-mail: chaunvv@oucru.org. Nguyen Thanh Hung and Le Bich Lien, Department of Dengue Haemorrhagic Fever, Children's Hospital Number 1, Ho Chi Minh City, Vietnam, E-mails: drthanhhung@gmail.com and doctorbichlien@yahoo.com. Tran Thi Thuy, Department of Infectious Diseases, Children's Hospital Number 2, Ho Chi Minh City, Vietnam, E-mail: mecudibu@yahoo.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Pediatric Dengue Vaccine Initiative, 2009. Global Burden of Dengue. Available at: http://www.pdvi.org/about_dengue/GBD.asp.
-
2.
Swaminathan S, Khanna N, 2009. Dengue: recent advances in biology and current status of translational research. Curr Mol Med 9: 152–173.
-
3.
Webster DP, Farrar J, Rowland-Jones S, 2009. Progress towards a dengue vaccine. Lancet Infect Dis 9: 678–687.
-
4.
Halstead SB, Voulgaropoulos EM, Tien NH, Udomsakdi S, 1965. Dengue hemorrhagic fever in South Vietnam: report of the 1963 outbreak. Am J Trop Med Hyg 14: 819–830.
-
5.
Halstead SB, 1997. Epidemiology of dengue and dengue hemorrhagic fever. Gubler DJ, Kuno G, eds. Dengue and Dengue Hemorrhagic Fever. Oxon, UK: CABI Publishing.
-
6.
Ha DQ, Tien NT, Huong VT, Loan HT, Thang CM, 2000. Dengue epidemic in southern Vietnam, 1998. Emerg Infect Dis 6: 422–425.
-
7.
Cummings DA, Iamsirithaworn S, Lessler JT, McDermott A, Prasanthong R, Nisalak A, Jarman RG, Burke DS, Gibbons RV, 2009. The impact of the demographic transition on dengue in Thailand: insights from a statistical analysis and mathematical modeling. PLoS Med 6: e1000139.
-
8.
Statistical Office of Ho Chi Minh City, 2009. Available at: http://www.pso.hochiminhcity.gov.vn/.
-
9.
World Health Organization, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control, 2nd ed. Geneva, Switzerland: World Health Organization.
-
10.
Simmons CP, Popper S, Dolocek C, Chau TN, Griffiths M, Dung NT, Long TH, Hoang DM, Chau NV, Thao le TT, Hien TT, Relman DA, Farrar J, 2007. Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever. J Infect Dis 195: 1097–1107.
-
11.
Vu TT, Holmes EC, Duong V, Nguyen TQ, Tran TH, Quail M, Churcher C, Parkhill J, Cardosa J, Farrar J, Wills B, Lennon NJ, Birren BW, Buchy P, Henn MR, Simmons CP, 2010. Emergence of the Asian 1 genotype of dengue virus serotype 2 in Viet Nam: in vivo fitness advantage and lineage replacement in South-East Asia. PLoS Negl Trop Dis 4: e757.
-
12.
Egger JR, Ooi EE, Kelly DW, Woolhouse ME, Davies CR, Coleman PG, 2008. Reconstructing historical changes in the force of infection of dengue fever in Singapore: implications for surveillance and control. Bull World Health Organ 86: 187–196.
-
13.
Guzman MG, Kouri G, Bravo J, Valdes L, Vazquez S, Halstead SB, 2002. Effect of age on outcome of secondary dengue 2 infections. Int J Infect Dis 6: 118–124.
-
14.
General Statistics Office of Vietnam, 2006. Household Living Standards Survey. Available at: http://www.gso.gov.vn/default_en.aspx?tabid=483&idmid=4&ItemID=8301.
-
15.
Chuang VW, Wong TY, Leung YH, Ma ES, Law YL, Tsang OT, Chan KM, Tsang IH, Que TL, Yung RW, Liu SH, 2008. Review of dengue fever cases in Hong Kong during 1998 to 2005. Hong Kong Med J 14: 170–177.
-
16.
Hammond SN, Balmaseda A, Perez L, Tellez Y, Saborio SI, Mercado JC, Videa E, Rodriguez Y, Perez MA, Cuadra R, Solano S, Rocha J, Idiaquez W, Gonzalez A, Harris E, 2005. Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua. Am J Trop Med Hyg 73: 1063–1070.
-
17.
Tantracheewathorn T, Tantracheewathorn S, 2007. Risk factors of dengue shock syndrome in children. J Med Assoc Thai 90: 272–277.
-
18.
Wang CC, Lee IK, Su MC, Lin HI, Huang YC, Liu SF, Wu CC, Lin MC, 2009. Differences in clinical and laboratory characteristics and disease severity between children and adults with dengue virus infection in Taiwan, 2002. Trans R Soc Trop Med Hyg 103: 871–877.
-
19.
Wichmann O, Hongsiriwon S, Bowonwatanuwong C, Chotivanich K, Sukthana Y, Pukrittayakamee S, 2004. Risk factors and clinical features associated with severe dengue infection in adults and children during the 2001 epidemic in Chonburi, Thailand. Trop Med Int Health 9: 1022–1029.
-
20.
Hon KL, Nelson EA, 2006. Gender disparity in paediatric hospital admissions. Ann Acad Med Singapore 35: 882–888.
-
21.
Halstead SB, Nimmannitya S, Cohen SN, 1970. Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. Yale J Biol Med 42: 311–328.
-
22.
Kabra SK, Jain Y, Pandey RM, Madhulika, Singhal T, Tripathi P, Broor S, Seth P, Seth V, 1999. Dengue haemorrhagic fever in children in the 1996 Delhi epidemic. Trans R Soc Trop Med Hyg 93: 294–298.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2671 | 1761 | 308 |
| Full Text Views | 954 | 22 | 5 |
| PDF Downloads | 605 | 33 | 7 |