Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Uyub AM, Raj SM, Visvanathan R, Nazim M, Aiyar S, Anuar AK, 1994. Helicobacter pylori infection in north-eastern peninsular Malaysia: evidence for an unusually low prevalence. Scand J Gastroenterol 29: 209–213.
-
2.
Raj SM, Yap K, Haq JA, Singh S, Hamid A, 2001. Further evidence for an exceptionally low prevalence of Helicobacter pylori infection among peptic ulcer patients in northeastern peninsular Malaysia. Trans R Soc Trop Med Hyg 95: 24–27.
-
3.
Goh KL, Parasakthi N, 2001. The racial cohort phenomenon: seroepidemiology of Helicobacter pylori infection in a multiracial south-east Asian country. Eur J Gastroenterol Hepatol 13: 177–183.
-
4.
Sasidharan S, Uyub AM, 2009. Prevalence of Helicobacter pylori infection among asymptomatic healthy blood donors in northern peninsular Malaysia. Trans R Soc Trop Med Hyg 103: 395–398.
-
5.
Sasidharan S, Uyub AM, Azlan AA, 2008. Further evidence of ethnic and gender differences for Helicobacter pylori infection among endoscoped patients. Trans R Soc Trop Med Hyg 102: 1226–1232.
-
6.
Graham DY, Yamaoka Y, Malaty HM, 2007. Thoughts about populations with unexpected low prevalences of Helicobacter pylori infection. Trans R Soc Trop Med Hyg 101: 849–851.
-
7.
Bonne C, Hartz H, Klerks JV, Posthuma JH, Radsma W, Tjokronegoro S, 1938. Morphology of the stomach and gastric secretion in Malays and Chinese and the different incidence of gastric ulcer and cancer in these races. Am J Cancer 33: 265–279.
-
8.
Tokudome S, Soeripto, Triningsih FX, Anantha I, Suzuki S, Kuruki K, 2005. Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia. Cancer Lett 219: 57–61.
-
9.
Iskandar C, 1976. Orang Asli: The Aboriginal Tribes of Peninsular Malaysia. Kuala Lumpur: Oxford University Press, 10–11.
-
10.
Geoffrey B, Cynthia C, 2002. Tribal Communities in the Malay World: Historical, Cultural and Social Perspectives. Singapore: Institute of Southeast Asian Studies, 7–205.
-
11.
Laheij RJ, Straatman H, Jansen JB, Verbeek AL, 1988. Evaluation of commercially available Helicobacter pylori serology kits: a review. J Clin Microbiol 36: 2803–2809.
-
12.
Raj SM, Lee YY, Choo KE, Noorizan AM, Zulkifli A, Radzi M, Ang SC, 2008. Further observations in an area with an exceptionally low prevalence of Helicobacter pylori infection. Trans R Soc Trop Med Hyg 102: 1163–1166.
-
13.
Tay CY, Mitchell H, Dong Q, Goh KL, Dawes IW, Lan R, 2009. Population structure of Helicobacter pylori among ethnic groups in Malaysia: recent acquisition of the bacterium by the Malay population. BMC Microbiol 9: 126.
-
14.
Mohamed R, Hanafiah A, Rose IM, Manaf MR, Abdullah SA, Sagap I, van Belkam A, Yaacob JA, 2009. Helicobacter pylori cagA gene variants in Malaysians of different ethnicity. Eur J Clin Microbiol Infect Dis 28: 865–869.
-
15.
Colin N, Center for Orang Asli Concerns, 1997. The Orang Asli of Peninsular Malaysia. Available at: http://www.magickriver.net/oa.htm. Accessed November 17, 2009.
-
16.
Nurgalieva ZZ, Malaty HM, Graham DY, Almuchambetova R, Machmudova A, Kapsultanova D, Osato MS, Hollinger FB, Zhangabylov A, 2002. Helicobacter pylori infection in Kazakhstan: effect of water source and household hygiene. Am J Trop Med Hyg 67: 201–206.
-
17.
Ahmed KS, Khan AA, Ahmed I, Tiwari SK, Habeeb A, Ahi JD, Abid Z, Ahmed N, Habibullah CM, 2007. Impact of household hygiene and water source on the prevalence and transmission of Helicobacter pylori: a south Indian perspective. Singapore Med J 48: 543–549.
-
18.
Zhang L, Eslick GD, Xia XH, Wu C, Phung N, Talley NJ, 2009. Relationship between alcohol consumption and active Helicobacter pylori infection. Alcohol Alcohol 45: 1–6.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 36 | 36 | 9 |
| Full Text Views | 276 | 101 | 0 |
| PDF Downloads | 73 | 38 | 0 |
Helicobacter pylori Infection among Aborigines (the Orang Asli) in the Northeastern Region of Peninsular Malaysia
Amry Abdul Rahim
Amry Abdul Rahim
Universiti Sains Malaysia, School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia; Pantai Medical Centre, Kuala Lumpur, Malaysia; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; Michael E. DeBakey Veteran Affairs Medical Center and Baylor College of Medicine, Houston, Texas
Search for other papers by Amry Abdul Rahim in
Current site
Google Scholar
PubMed
Search for other papers by Amry Abdul Rahim in
Current site
Google Scholar
PubMed
Yeong Yeh Lee
Yeong Yeh Lee
Universiti Sains Malaysia, School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia; Pantai Medical Centre, Kuala Lumpur, Malaysia; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; Michael E. DeBakey Veteran Affairs Medical Center and Baylor College of Medicine, Houston, Texas
Search for other papers by Yeong Yeh Lee in
Current site
Google Scholar
PubMed
Search for other papers by Yeong Yeh Lee in
Current site
Google Scholar
PubMed
Noorizan Abd Majid
Noorizan Abd Majid
Universiti Sains Malaysia, School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia; Pantai Medical Centre, Kuala Lumpur, Malaysia; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; Michael E. DeBakey Veteran Affairs Medical Center and Baylor College of Medicine, Houston, Texas
Search for other papers by Noorizan Abd Majid in
Current site
Google Scholar
PubMed
Search for other papers by Noorizan Abd Majid in
Current site
Google Scholar
PubMed
Keng Ee Choo
Keng Ee Choo
Universiti Sains Malaysia, School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia; Pantai Medical Centre, Kuala Lumpur, Malaysia; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; Michael E. DeBakey Veteran Affairs Medical Center and Baylor College of Medicine, Houston, Texas
Search for other papers by Keng Ee Choo in
Current site
Google Scholar
PubMed
Search for other papers by Keng Ee Choo in
Current site
Google Scholar
PubMed
Sundramoorthy Mahendra Raj
Sundramoorthy Mahendra Raj
Universiti Sains Malaysia, School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia; Pantai Medical Centre, Kuala Lumpur, Malaysia; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; Michael E. DeBakey Veteran Affairs Medical Center and Baylor College of Medicine, Houston, Texas
Search for other papers by Sundramoorthy Mahendra Raj in
Current site
Google Scholar
PubMed
Search for other papers by Sundramoorthy Mahendra Raj in
Current site
Google Scholar
PubMed
Mohammad H. Derakhshan
Mohammad H. Derakhshan
Universiti Sains Malaysia, School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia; Pantai Medical Centre, Kuala Lumpur, Malaysia; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; Michael E. DeBakey Veteran Affairs Medical Center and Baylor College of Medicine, Houston, Texas
Search for other papers by Mohammad H. Derakhshan in
Current site
Google Scholar
PubMed
Search for other papers by Mohammad H. Derakhshan in
Current site
Google Scholar
PubMed
David Y. Graham
David Y. Graham
Universiti Sains Malaysia, School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia; Pantai Medical Centre, Kuala Lumpur, Malaysia; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; Michael E. DeBakey Veteran Affairs Medical Center and Baylor College of Medicine, Houston, Texas
Search for other papers by David Y. Graham in
Current site
Google Scholar
PubMed
Search for other papers by David Y. Graham in
Current site
Google Scholar
PubMed
Whether the exceptionally low prevalence of Helicobacter pylori (HP) infection reported among Malays is also present among aborigines (the Orang Asli) living in northeastern Peninsular Malaysia is unknown. We studied asymptomatic Orang Asli from settlements situated 210 km from the city of Kota Bharu. The HP infection status was confirmed by a validated serology test. Nineteen percent of 480 Orang Asli tested positive for HP infection. The prevalence was 40.6% in the birth cohort of the 1940s and declined steadily in later cohorts to under 10% among 12–30 year olds. This may be related to the phases of relocation from the jungles into resettlement camps and ultimately into designated villages near rivers. The low prevalence pattern after the 1970s was probably partly a result of improvement in sanitation and hygiene practice in these villages but other unidentified factors may also be operating.
Author Notes
Financial support: The study was supported by the Universiti Sains Malaysia (USM) short term grant (reference: 304/PPSP/6131251).
Disclosure: David Y. Graham is a consultant for Novartis in relation to vaccine development for treatment or prevention of H. pylori infection. He is also a paid consultant for Otsuka Pharmaceuticals and until July 2007 was a member of the Board of Directors of Meretek Diagnostics, the manufacturer of the 13C-urea breath test. He also receives royalties on the Baylor College of Medicine patent covering materials related to 13C-urea breath test. All other authors report no relevant conflicts.
Authors' addresses: Amry Abdul Rahim and Yeong Yeh Lee, Department of Medicine, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia, E-mails: dramryusm@hotmail.com and yylee@kck.usm.my. Noorizan Abdul Majid and Keng Ee Choo, Department of Paediatrics, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia, E-mails: noorizan@kb.usm.my and kechoo@kb.usm.my. Sundramoorthy Mahendra Raj, Pantai Hospital, Kuala Lumpur, Malaysia, E-mail: mahendraraj58@gmail.com. Mohammad H. Derakhshan, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, E-mail: m.derakhshan@clinmed.gla.ac.uk. David Y. Graham, Michael E. DeBakey Veteran Affairs Medical Center and Baylor College of Medicine, Houston, TX, E-mail: dgraham@bcm.tmc.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Uyub AM, Raj SM, Visvanathan R, Nazim M, Aiyar S, Anuar AK, 1994. Helicobacter pylori infection in north-eastern peninsular Malaysia: evidence for an unusually low prevalence. Scand J Gastroenterol 29: 209–213.
-
2.
Raj SM, Yap K, Haq JA, Singh S, Hamid A, 2001. Further evidence for an exceptionally low prevalence of Helicobacter pylori infection among peptic ulcer patients in northeastern peninsular Malaysia. Trans R Soc Trop Med Hyg 95: 24–27.
-
3.
Goh KL, Parasakthi N, 2001. The racial cohort phenomenon: seroepidemiology of Helicobacter pylori infection in a multiracial south-east Asian country. Eur J Gastroenterol Hepatol 13: 177–183.
-
4.
Sasidharan S, Uyub AM, 2009. Prevalence of Helicobacter pylori infection among asymptomatic healthy blood donors in northern peninsular Malaysia. Trans R Soc Trop Med Hyg 103: 395–398.
-
5.
Sasidharan S, Uyub AM, Azlan AA, 2008. Further evidence of ethnic and gender differences for Helicobacter pylori infection among endoscoped patients. Trans R Soc Trop Med Hyg 102: 1226–1232.
-
6.
Graham DY, Yamaoka Y, Malaty HM, 2007. Thoughts about populations with unexpected low prevalences of Helicobacter pylori infection. Trans R Soc Trop Med Hyg 101: 849–851.
-
7.
Bonne C, Hartz H, Klerks JV, Posthuma JH, Radsma W, Tjokronegoro S, 1938. Morphology of the stomach and gastric secretion in Malays and Chinese and the different incidence of gastric ulcer and cancer in these races. Am J Cancer 33: 265–279.
-
8.
Tokudome S, Soeripto, Triningsih FX, Anantha I, Suzuki S, Kuruki K, 2005. Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia. Cancer Lett 219: 57–61.
-
9.
Iskandar C, 1976. Orang Asli: The Aboriginal Tribes of Peninsular Malaysia. Kuala Lumpur: Oxford University Press, 10–11.
-
10.
Geoffrey B, Cynthia C, 2002. Tribal Communities in the Malay World: Historical, Cultural and Social Perspectives. Singapore: Institute of Southeast Asian Studies, 7–205.
-
11.
Laheij RJ, Straatman H, Jansen JB, Verbeek AL, 1988. Evaluation of commercially available Helicobacter pylori serology kits: a review. J Clin Microbiol 36: 2803–2809.
-
12.
Raj SM, Lee YY, Choo KE, Noorizan AM, Zulkifli A, Radzi M, Ang SC, 2008. Further observations in an area with an exceptionally low prevalence of Helicobacter pylori infection. Trans R Soc Trop Med Hyg 102: 1163–1166.
-
13.
Tay CY, Mitchell H, Dong Q, Goh KL, Dawes IW, Lan R, 2009. Population structure of Helicobacter pylori among ethnic groups in Malaysia: recent acquisition of the bacterium by the Malay population. BMC Microbiol 9: 126.
-
14.
Mohamed R, Hanafiah A, Rose IM, Manaf MR, Abdullah SA, Sagap I, van Belkam A, Yaacob JA, 2009. Helicobacter pylori cagA gene variants in Malaysians of different ethnicity. Eur J Clin Microbiol Infect Dis 28: 865–869.
-
15.
Colin N, Center for Orang Asli Concerns, 1997. The Orang Asli of Peninsular Malaysia. Available at: http://www.magickriver.net/oa.htm. Accessed November 17, 2009.
-
16.
Nurgalieva ZZ, Malaty HM, Graham DY, Almuchambetova R, Machmudova A, Kapsultanova D, Osato MS, Hollinger FB, Zhangabylov A, 2002. Helicobacter pylori infection in Kazakhstan: effect of water source and household hygiene. Am J Trop Med Hyg 67: 201–206.
-
17.
Ahmed KS, Khan AA, Ahmed I, Tiwari SK, Habeeb A, Ahi JD, Abid Z, Ahmed N, Habibullah CM, 2007. Impact of household hygiene and water source on the prevalence and transmission of Helicobacter pylori: a south Indian perspective. Singapore Med J 48: 543–549.
-
18.
Zhang L, Eslick GD, Xia XH, Wu C, Phung N, Talley NJ, 2009. Relationship between alcohol consumption and active Helicobacter pylori infection. Alcohol Alcohol 45: 1–6.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 36 | 36 | 9 |
| Full Text Views | 276 | 101 | 0 |
| PDF Downloads | 73 | 38 | 0 |