Quantiferon-Leishmania as an Epidemiological Tool for Evaluating the Exposure to Leishmania Infection

Nevin Turgay Department of Parasitology, Ege University Medical School, Izmir, Turkey; Department of Parasitology, Celal Bayar University Medical School, Manisa, Turkey; Cellestis Limited, Carnegie, Australia

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I. Cuneyt Balcioglu Department of Parasitology, Ege University Medical School, Izmir, Turkey; Department of Parasitology, Celal Bayar University Medical School, Manisa, Turkey; Cellestis Limited, Carnegie, Australia

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Seray Ozensoy Toz Department of Parasitology, Ege University Medical School, Izmir, Turkey; Department of Parasitology, Celal Bayar University Medical School, Manisa, Turkey; Cellestis Limited, Carnegie, Australia

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Yusuf Ozbel Department of Parasitology, Ege University Medical School, Izmir, Turkey; Department of Parasitology, Celal Bayar University Medical School, Manisa, Turkey; Cellestis Limited, Carnegie, Australia

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Stephen L. Jones Department of Parasitology, Ege University Medical School, Izmir, Turkey; Department of Parasitology, Celal Bayar University Medical School, Manisa, Turkey; Cellestis Limited, Carnegie, Australia

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DOI:
https://doi.org/10.4269/ajtmh.2010.09-0605
Volume/Issue:
Volume 83: Issue 4
Page(s):
822–824
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The aim of the present preliminary study was to investigate the potential of measurement of IFN-γ secretion by T cells into blood plasma using QuantiFERON assay with leishmanial antigens to determine the presence of Leishmania infection. Blood samples from cured visceral (N = 18), and cutaneous (N = 20) leishmaniasis cases, and 20 healthy controls were tested. The IFN-γ responses to Leishmania major H2B and Leishmania infantum H2B antigens were detected from the majority of treated old visceral leishmaniasis cases, but not from controls. Future studies using larger groups will be required to establish the true potential of the assay for epidemiological screening of leishmaniasis.

Author Notes

*Address correspondence to Nevin Turgay, Ege University Medical School, Department of Parasitology, Bornova, Izmir 35100. E-mail: nevin-turgay@ege.edu.tr

Authors' addresses: Nevin Turgay, Seray Ozensoy Toz, and Yusuf Ozbel, Department of Parasitology, Ege University Medical School, Izmir, Turkey, E-mails: nevin.turgay@ege.edu.tr, seray.ozensoy.toz@ege.edu.tr, and yusuf.ozbel@ege.edu.tr. I. Cuneyt Balcioglu, Department of Parasitology, Celal Bayar University Medical School, Manisa, Turkey, E-mail: drcbal@yahoo.com. Stephen L. Jones, Cellestis Limited, Carnegie, Australia, E-mail: sjones@cellestis.com.

Copyright:
©The American Society of Tropical Medicine and Hygiene 2010
Received:
09 Oct 2009
|
Accepted:
03 May 2010
|
Published Online:
05 Oct 2010
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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