ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Guzman MG, Kouri G, 2003. Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges. J Clin Virol 27: 1–13.
-
2.
Monath TP, 1994. Dengue: the risk to developed and developing countries. Proc Natl Acad Sci USA 91: 2395–2400.
-
3.
Gubler DJ, Clark GG, 1995. Dengue/dengue hemorrhagic fever: the emergence of a global health problem. Emerg Infect Dis 1: 55–57.
-
4.
Kyle JL, Harris E, 2008. Global spread and persistence of dengue. Annu Rev Microbiol 62: 71–92.
-
5.
Clyde K, Kyle JL, Harris E, 2006. Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis. J Virol 80: 11418–11431.
-
6.
Rico-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C, Boshell J, de Mesa MT, Nogueira RM, da Rosa AT, 1997. Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology 230: 244–251.
-
7.
Lanciotti RS, Lewis JG, Gubler DJ, Trent DW, 1994. Molecular evolution and epidemiology of dengue-3 viruses. J Gen Virol 75: 65–75.
-
8.
Messer WB, Gubler DJ, Harris E, Sivananthan K, de Silva AM, 2003. Emergence and global spread of a dengue serotype 3, subtype III virus. Emerg Infect Dis 9: 800–809.
-
9.
CDC, 1995. Dengue type 3 infection–Nicaragua and Panama, October–November 1994. MMWR Morb Mortal Wkly Rep 44: 21–24.
-
10.
Guzman MG, Vazquez S, Martinez E, Alvarez M, Rodriguez R, Kouri G, de los Reyes J, Acevedo F, 1996. Dengue in Nicaragua, 1994: reintroduction of serotype 3 in the Americas. Bol Oficina Sanit Panam 121: 102–110.
-
11.
Balmaseda A, Sandoval E, Perez L, Gutierrez CM, Harris E, 1999. Application of molecular typing techniques in the 1998 dengue epidemic in Nicaragua. Am J Trop Med Hyg 61: 893–897.
-
12.
Usuku S, Castillo L, Sugimoto C, Noguchi Y, Yogo Y, Kobayashi N, 2001. Phylogenetic analysis of dengue-3 viruses prevalent in Guatemala during 1996–1998. Arch Virol 146: 1381–1390.
-
13.
Diaz FJ, Black WC 4th, Farfan-Ale JA, Lorono-Pino MA, Olson KE, Beaty BJ, 2006. Dengue virus circulation and evolution in Mexico: a phylogenetic perspective. Arch Med Res 37: 760–773.
-
14.
Peyrefitte CN, Couissinier-Paris P, Mercier-Perennec V, Bessaud M, Martial J, Kenane N, Durand JP, Tolou HJ, 2003. Genetic characterization of newly reintroduced dengue virus type 3 in Martinique (French West Indies). J Clin Microbiol 41: 5195–5198.
-
15.
Peyrefitte CN, Pastorino BA, Bessaud M, Gravier P, Tock F, Couissinier-Paris P, Martial J, Huc-Anais P, Cesaire R, Grandadam M, Tolou HJ, 2005. Dengue type 3 virus, Saint Martin, 2003–2004. Emerg Infect Dis 11: 757–761.
-
16.
Rodriguez-Roche R, Alvarez M, Holmes EC, Bernardo L, Kouri G, Gould EA, Halstead S, Guzman MG, 2005. Dengue virus type 3, Cuba, 2000–2002. Emerg Infect Dis 11: 773–774.
-
17.
Kochel T, Aguilar P, Felices V, Comach G, Cruz C, Alava A, Vargas J, Olson J, Blair P, 2008. Molecular epidemiology of dengue virus type 3 in northern South America: 2000–2005. Infect Genet Evol 8: 682–688.
-
18.
Uzcategui NY, Comach G, Camacho D, Salcedo M, Cabello de Quintana M, Jimenez M, Sierra G, Cuello de Uzcategui R, James WS, Turner S, Holmes EC, Gould EA, 2003. Molecular epidemiology of dengue virus type 3 in Venezuela. J Gen Virol 84: 1569–1575.
-
19.
Miagostovich MP, dos Santos FB, de Simone TS, Costa EV, Filippis AM, Schatzmayr HG, Nogueira RM, 2002. Genetic characterization of dengue virus type 3 isolates in the State of Rio de Janeiro, 2001. Braz J Med Biol Res 35: 869–872.
-
20.
Nogueira RM, Schatzmayr HG, de Filippis AM, dos Santos FB, da Cunha RV, Coelho JO, de Souza LJ, Guimaraes FR, de Araujo ES, De Simone TS, Baran M, Teixeira G Jr, Miagostovich MP, 2005. Dengue virus type 3, Brazil, 2002. Emerg Infect Dis 11: 1376–1381.
-
21.
Diaz FJ, Farfan-Ale JA, Olson KE, Lorono-Pino MA, Gubler DJ, Blair CD, Black WC 4th, Beaty BJ, 2002. Genetic variation within the premembrane coding region of dengue viruses from the Yucatan peninsula of Mexico. Am J Trop Med Hyg 67: 93–101.
-
22.
Aquino VH, Anatriello E, Goncalves PF, DA Silva EV, Vasconcelos PF, Vieira DS, Batista WC, Bobadilla ML, Vazquez C, Moran M, Figueiredo LT, 2006. Molecular epidemiology of dengue type 3 virus in Brazil and Paraguay, 2002–2004. Am J Trop Med Hyg 75: 710–715.
-
23.
Barrero PR, Mistchenko AS, 2008. Genetic analysis of dengue virus type 3 isolated in Buenos Aires, Argentina. Virus Res 135: 83–88.
-
24.
Araujo JM, Nogueira RM, Schatzmayr HG, Zanotto PM, Bello G, 2009. Phylogeography and evolutionary history of dengue virus type 3. Infect Genet Evol 9: 716–725.
-
25.
Bordignon-Nogueira M, Stella V, Bordignon J, Batista W, de Borba L, Pereira da Silva L, Hoffmann F, Probst C, Duarte dos Santos C, 2008. Evidence for the co-circulation of dengue virus type 3 genotypes III and V in the northern region of Brazil during the 2002–2004 epidemics. Mem Inst Oswaldo Cruz 103: 483–488.
-
26.
Figueiredo L, Cecílio A, Portela Ferreira G, Drumond B, Germano de Oliveira J, Bonjardim C, Peregrino Ferreira P, Kroon E, 2008. Dengue virus 3 genotype 1 associated with dengue fever and dengue hemorrhagic fever, Brazil. Emerg Infect Dis 14: 314–316.
-
27.
Usme-Ciro JA, Mendez JA, Tenorio A, Rey GJ, Domingo C, Gallego-Gomez JC, 2008. Simultaneous circulation of genotypes I and III of dengue virus 3 in Colombia. Virol J 5: 101.
-
28.
Groot H, 1980. The reinvasion of Colombia by Aedes aegypti: aspects to remember. Am J Trop Med Hyg 29: 330–338.
-
29.
Ocazionez RE, Cortes FM, Villar LA, Gomez SY, 2006. Temporal distribution of dengue virus serotypes in Colombian endemic area and dengue incidence. Re-introduction of dengue-3 associated to mild febrile illness and primary infection. Mem Inst Oswaldo Cruz 101: 725–731.
-
30.
Diaz F, Ospina M, Higuita E, Osorio J, 2007. Molecular characterization of dengue viruses isolated in Medellín, Colombia. Meeting of the American Society of Tropical Medicine and Hygiene, Philadelphia, PA.
-
31.
WHO, 1999. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Geneva: WHO.
-
32.
Worobey M, Rambaut A, Holmes EC, 1999. Widespread intra-serotype recombination in natural populations of dengue virus. Proc Natl Acad Sci USA 96: 7352–7357.
-
33.
Drummond AJ, Rambaut A, 2007. BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evol Biol 7: 214.
-
34.
Shapiro B, Rambaut A, Drummond AJ, 2006. Choosing appropriate substitution models for the phylogenetic analysis of protein-coding sequences. Mol Biol Evol 23: 7–9.
-
35.
Kumar S, Tamura K, Nei M, 2004. MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform 5: 150–163.
-
36.
Wittke V, Robb TE, Thu HM, Nisalak A, Nimmannitya S, Kalayanrooj S, Vaughn DW, Endy TP, Holmes EC, Aaskov JG, 2002. Extinction and rapid emergence of strains of dengue 3 virus during an interepidemic period. Virology 301: 148–156.
-
37.
Nei M, Gojobori T, 1986. Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol Biol Evol 3: 418–426.
-
38.
Modis Y, Ogata S, Clements D, Harrison SC, 2005. Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein. J Virol 79: 1223–1231.
-
39.
Myat Thu H, Lowry K, Jiang L, Hlaing T, Holmes EC, Aaskov J, 2005. Lineage extinction and replacement in dengue type 1 virus populations are due to stochastic events rather than to natural selection. Virology 336: 163–172.
-
40.
Thu HM, Lowry K, Myint TT, Shwe TN, Han AM, Khin KK, Thant KZ, Thein S, Aaskov J, 2004. Myanmar dengue outbreak associated with displacement of serotypes 2, 3, and 4 by dengue 1. Emerg Infect Dis 10: 593–597.
-
41.
Miagostovich MP, dos Santos FB, Fumian TM, Guimaraes FR, da Costa EV, Tavares FN, Coelho JO, Nogueira RM, 2006. Complete genetic characterization of a Brazilian dengue virus type 3 strain isolated from a fatal outcome. Mem Inst Oswaldo Cruz 101: 307–313.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 670 | 596 | 9 |
| Full Text Views | 274 | 8 | 0 |
| PDF Downloads | 81 | 10 | 0 |
Prolonged Co-circulation of Two Distinct Dengue Virus Type 3 Lineages in the Hyperendemic Area of Medellín, Colombia
Marta C. Ospina
Marta C. Ospina
Dirección Seccional de Salud y Protección Social de Antioquia, Laboratorio Departamental de Salud Pública de Antioquia, Medellín, Colombia; Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin
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Francisco J. Diaz
Francisco J. Diaz
Dirección Seccional de Salud y Protección Social de Antioquia, Laboratorio Departamental de Salud Pública de Antioquia, Medellín, Colombia; Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin
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Jorge E. Osorio
Jorge E. Osorio
Dirección Seccional de Salud y Protección Social de Antioquia, Laboratorio Departamental de Salud Pública de Antioquia, Medellín, Colombia; Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin
Search for other papers by Jorge E. Osorio in
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PubMed
During the past two decades, Dengue virus-3 (DENV-3) has re-emerged in the Western Hemisphere causing significant epidemics of dengue fever (DF) and dengue hemorrhagic fever (DHF). In an effort to understand the molecular evolution of DENV-3 and their relationships to other DENV-3 circulating in the western hemisphere, we conducted a phylogenetic study on DENV-3 isolates made between 2002 and 2007 in the metropolitan area of Medellín, Colombia. An unexpected co-circulation of two different variants of DENV-3 subtype III during at least 5 years in Medellín was found. In addition, a more complete analysis of DENV-3 viruses isolated in other South American regions revealed the existence of three different subtype III lineages, all derived from independent introductions. This study documents significant genetic diversity of circulating viruses within the same subtype and an unusual capacity of the population of this city to support continuous circulation of multiple variants of dengue virus.
Author Notes
Financial support: This work was supported by a career development Research Award from The Gorgas Memorial Foundation of Tropical and Preventive Medicine.
Disclosure: J. Osorio is a co-founder of Invivagen, Inc., a company working on the development of a dengue vaccine. This statement is made in the interest of full disclosure and not because the author considers this to be a conflict of interest.
Authors' addresses: Marta C. Ospina, Dirección Seccional de Salud y Protección Social de Antioquia, Laboratorio Departamental de Salud Pública de Antioquia, Medellín, Colombia, E-mail: franciscodiaz314@gmail.com. Francisco J. Diaz, Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia, E-mail: mospinao@antioquia.gov.co. Jorge E. Osorio, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, E-mail: osorio@svm.vetmed.wisc.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Guzman MG, Kouri G, 2003. Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges. J Clin Virol 27: 1–13.
-
2.
Monath TP, 1994. Dengue: the risk to developed and developing countries. Proc Natl Acad Sci USA 91: 2395–2400.
-
3.
Gubler DJ, Clark GG, 1995. Dengue/dengue hemorrhagic fever: the emergence of a global health problem. Emerg Infect Dis 1: 55–57.
-
4.
Kyle JL, Harris E, 2008. Global spread and persistence of dengue. Annu Rev Microbiol 62: 71–92.
-
5.
Clyde K, Kyle JL, Harris E, 2006. Recent advances in deciphering viral and host determinants of dengue virus replication and pathogenesis. J Virol 80: 11418–11431.
-
6.
Rico-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C, Boshell J, de Mesa MT, Nogueira RM, da Rosa AT, 1997. Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas. Virology 230: 244–251.
-
7.
Lanciotti RS, Lewis JG, Gubler DJ, Trent DW, 1994. Molecular evolution and epidemiology of dengue-3 viruses. J Gen Virol 75: 65–75.
-
8.
Messer WB, Gubler DJ, Harris E, Sivananthan K, de Silva AM, 2003. Emergence and global spread of a dengue serotype 3, subtype III virus. Emerg Infect Dis 9: 800–809.
-
9.
CDC, 1995. Dengue type 3 infection–Nicaragua and Panama, October–November 1994. MMWR Morb Mortal Wkly Rep 44: 21–24.
-
10.
Guzman MG, Vazquez S, Martinez E, Alvarez M, Rodriguez R, Kouri G, de los Reyes J, Acevedo F, 1996. Dengue in Nicaragua, 1994: reintroduction of serotype 3 in the Americas. Bol Oficina Sanit Panam 121: 102–110.
-
11.
Balmaseda A, Sandoval E, Perez L, Gutierrez CM, Harris E, 1999. Application of molecular typing techniques in the 1998 dengue epidemic in Nicaragua. Am J Trop Med Hyg 61: 893–897.
-
12.
Usuku S, Castillo L, Sugimoto C, Noguchi Y, Yogo Y, Kobayashi N, 2001. Phylogenetic analysis of dengue-3 viruses prevalent in Guatemala during 1996–1998. Arch Virol 146: 1381–1390.
-
13.
Diaz FJ, Black WC 4th, Farfan-Ale JA, Lorono-Pino MA, Olson KE, Beaty BJ, 2006. Dengue virus circulation and evolution in Mexico: a phylogenetic perspective. Arch Med Res 37: 760–773.
-
14.
Peyrefitte CN, Couissinier-Paris P, Mercier-Perennec V, Bessaud M, Martial J, Kenane N, Durand JP, Tolou HJ, 2003. Genetic characterization of newly reintroduced dengue virus type 3 in Martinique (French West Indies). J Clin Microbiol 41: 5195–5198.
-
15.
Peyrefitte CN, Pastorino BA, Bessaud M, Gravier P, Tock F, Couissinier-Paris P, Martial J, Huc-Anais P, Cesaire R, Grandadam M, Tolou HJ, 2005. Dengue type 3 virus, Saint Martin, 2003–2004. Emerg Infect Dis 11: 757–761.
-
16.
Rodriguez-Roche R, Alvarez M, Holmes EC, Bernardo L, Kouri G, Gould EA, Halstead S, Guzman MG, 2005. Dengue virus type 3, Cuba, 2000–2002. Emerg Infect Dis 11: 773–774.
-
17.
Kochel T, Aguilar P, Felices V, Comach G, Cruz C, Alava A, Vargas J, Olson J, Blair P, 2008. Molecular epidemiology of dengue virus type 3 in northern South America: 2000–2005. Infect Genet Evol 8: 682–688.
-
18.
Uzcategui NY, Comach G, Camacho D, Salcedo M, Cabello de Quintana M, Jimenez M, Sierra G, Cuello de Uzcategui R, James WS, Turner S, Holmes EC, Gould EA, 2003. Molecular epidemiology of dengue virus type 3 in Venezuela. J Gen Virol 84: 1569–1575.
-
19.
Miagostovich MP, dos Santos FB, de Simone TS, Costa EV, Filippis AM, Schatzmayr HG, Nogueira RM, 2002. Genetic characterization of dengue virus type 3 isolates in the State of Rio de Janeiro, 2001. Braz J Med Biol Res 35: 869–872.
-
20.
Nogueira RM, Schatzmayr HG, de Filippis AM, dos Santos FB, da Cunha RV, Coelho JO, de Souza LJ, Guimaraes FR, de Araujo ES, De Simone TS, Baran M, Teixeira G Jr, Miagostovich MP, 2005. Dengue virus type 3, Brazil, 2002. Emerg Infect Dis 11: 1376–1381.
-
21.
Diaz FJ, Farfan-Ale JA, Olson KE, Lorono-Pino MA, Gubler DJ, Blair CD, Black WC 4th, Beaty BJ, 2002. Genetic variation within the premembrane coding region of dengue viruses from the Yucatan peninsula of Mexico. Am J Trop Med Hyg 67: 93–101.
-
22.
Aquino VH, Anatriello E, Goncalves PF, DA Silva EV, Vasconcelos PF, Vieira DS, Batista WC, Bobadilla ML, Vazquez C, Moran M, Figueiredo LT, 2006. Molecular epidemiology of dengue type 3 virus in Brazil and Paraguay, 2002–2004. Am J Trop Med Hyg 75: 710–715.
-
23.
Barrero PR, Mistchenko AS, 2008. Genetic analysis of dengue virus type 3 isolated in Buenos Aires, Argentina. Virus Res 135: 83–88.
-
24.
Araujo JM, Nogueira RM, Schatzmayr HG, Zanotto PM, Bello G, 2009. Phylogeography and evolutionary history of dengue virus type 3. Infect Genet Evol 9: 716–725.
-
25.
Bordignon-Nogueira M, Stella V, Bordignon J, Batista W, de Borba L, Pereira da Silva L, Hoffmann F, Probst C, Duarte dos Santos C, 2008. Evidence for the co-circulation of dengue virus type 3 genotypes III and V in the northern region of Brazil during the 2002–2004 epidemics. Mem Inst Oswaldo Cruz 103: 483–488.
-
26.
Figueiredo L, Cecílio A, Portela Ferreira G, Drumond B, Germano de Oliveira J, Bonjardim C, Peregrino Ferreira P, Kroon E, 2008. Dengue virus 3 genotype 1 associated with dengue fever and dengue hemorrhagic fever, Brazil. Emerg Infect Dis 14: 314–316.
-
27.
Usme-Ciro JA, Mendez JA, Tenorio A, Rey GJ, Domingo C, Gallego-Gomez JC, 2008. Simultaneous circulation of genotypes I and III of dengue virus 3 in Colombia. Virol J 5: 101.
-
28.
Groot H, 1980. The reinvasion of Colombia by Aedes aegypti: aspects to remember. Am J Trop Med Hyg 29: 330–338.
-
29.
Ocazionez RE, Cortes FM, Villar LA, Gomez SY, 2006. Temporal distribution of dengue virus serotypes in Colombian endemic area and dengue incidence. Re-introduction of dengue-3 associated to mild febrile illness and primary infection. Mem Inst Oswaldo Cruz 101: 725–731.
-
30.
Diaz F, Ospina M, Higuita E, Osorio J, 2007. Molecular characterization of dengue viruses isolated in Medellín, Colombia. Meeting of the American Society of Tropical Medicine and Hygiene, Philadelphia, PA.
-
31.
WHO, 1999. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Geneva: WHO.
-
32.
Worobey M, Rambaut A, Holmes EC, 1999. Widespread intra-serotype recombination in natural populations of dengue virus. Proc Natl Acad Sci USA 96: 7352–7357.
-
33.
Drummond AJ, Rambaut A, 2007. BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evol Biol 7: 214.
-
34.
Shapiro B, Rambaut A, Drummond AJ, 2006. Choosing appropriate substitution models for the phylogenetic analysis of protein-coding sequences. Mol Biol Evol 23: 7–9.
-
35.
Kumar S, Tamura K, Nei M, 2004. MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform 5: 150–163.
-
36.
Wittke V, Robb TE, Thu HM, Nisalak A, Nimmannitya S, Kalayanrooj S, Vaughn DW, Endy TP, Holmes EC, Aaskov JG, 2002. Extinction and rapid emergence of strains of dengue 3 virus during an interepidemic period. Virology 301: 148–156.
-
37.
Nei M, Gojobori T, 1986. Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol Biol Evol 3: 418–426.
-
38.
Modis Y, Ogata S, Clements D, Harrison SC, 2005. Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein. J Virol 79: 1223–1231.
-
39.
Myat Thu H, Lowry K, Jiang L, Hlaing T, Holmes EC, Aaskov J, 2005. Lineage extinction and replacement in dengue type 1 virus populations are due to stochastic events rather than to natural selection. Virology 336: 163–172.
-
40.
Thu HM, Lowry K, Myint TT, Shwe TN, Han AM, Khin KK, Thant KZ, Thein S, Aaskov J, 2004. Myanmar dengue outbreak associated with displacement of serotypes 2, 3, and 4 by dengue 1. Emerg Infect Dis 10: 593–597.
-
41.
Miagostovich MP, dos Santos FB, Fumian TM, Guimaraes FR, da Costa EV, Tavares FN, Coelho JO, Nogueira RM, 2006. Complete genetic characterization of a Brazilian dengue virus type 3 strain isolated from a fatal outcome. Mem Inst Oswaldo Cruz 101: 307–313.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 670 | 596 | 9 |
| Full Text Views | 274 | 8 | 0 |
| PDF Downloads | 81 | 10 | 0 |