Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Ferrari S, Vento S, Monaco S, Cavallaro T, Cainelli F, Rizzuto N, Temesgen Z, 2006. Human immunodeficiency virus-associated peripheral neuropathies. Mayo Clin Proc 81: 213–219.
-
2.
Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach. Available at: http://www.who.int/hiv/pub/guidelines/artadultguidelines.pdf. Accessed June 2, 2010.
-
3.
Boulle A, Orrel C, Kaplan R, Van Cutsem G, McNally M, Hilderbrand K, Myer L, Egger M, Coetzee D, Maartens G, Wood R, 2007. Substitutions due to antiretroviral toxicity or contraindication in the first 3 years of antiretroviral therapy in a large South African cohort. Antivir Ther 12: 753–760.
-
4.
Forna F, Liechty CA, Solberg P, Asiimwe F, Were W, Mermin J, Behumbiize P, Tong T, Brooks JT, Weidle PJ, 2007. Clinical toxicity of highly active antiretroviral therapy in a home-based AIDS care program in rural Uganda. J Acquir Immune Defic Syndr 44: 456–462.
-
5.
Hawkins C, Achenbach C, Fryda W, Ngare D, Murphy R, 2007. Antiretroviral durability and tolerability in HIV-infected adults living in urban Kenya. J Acquir Immune Defic Syndr 45: 304–310.
-
6.
Hoffmann CJ, Fielding KL, Charalambous S, Sulkowski MS, Innes C, Thio CL, Chaisson RE, Churchyard GJ, Grant AD, 2008. Antiretroviral therapy using zidovudine, lamivudine, and efavirenz in South Africa: tolerability and clinical events. AIDS 22: 67–74.
-
7.
Millogo A, Lankoande D, Yameogo I, Yameogo AA, Sawadogo AB, 2008. Polyneuropathies in patients treated with HAART in Bobo-Dioulasso hospital, Burkina Faso [in French]. Bull Soc Pathol Exot 101: 11–13.
-
8.
van Oosterhout JJ, Bodasing N, Kumwenda JJ, Nyirenda C, Mallewa J, Cleary PR, de Baar MP, Schuurman R, Burger DM, Zijlstra EE, 2005. Evaluation of antiretroviral therapy results in a resource-poor setting in Blantyre, Malawi. Trop Med Int Health 10: 464–470.
-
9.
Wester CW, Kim S, Bussmann H, Avalos A, Ndwapi N, Peter TF, Gaolathe T, Mujugira A, Busang L, Vanderwarker C, Cardiello P, Johnson O, Thior I, Mazonde P, Moffat H, Essex M, Marlink R, 2005. Initial response to highly active antiretroviral therapy in HIV-1C-infected adults in a public sector treatment program in Botswana. J Acquir Immune Defic Syndr 40: 336–343.
-
10.
Cherry CL, Wesselingh SL, Lal L, McArthur JC, 2005. Evaluation of a clinical screening tool for HIV-associated sensory neuropathies. Neurology 65: 1778–1781.
-
11.
Simpson DM, Kitch D, Evans SR, McArthur JC, Asmuth DM, Cohen B, Goodkin K, Gerschenson M, So Y, Marra CM, Diaz-Arrastia R, Shriver S, Millar L, Clifford DB, 2006. HIV neuropathy natural history cohort study: assessment measures and risk factors. Neurology 66: 1679–1687.
-
12.
WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children. Available at: http://www.who.int/hiv/pub/guidelines/HIVstaging150307.pdf. Accessed June 2, 2010.
-
13.
Maritz J, Benatar M, Dave JA, Harrison TB, Badri M, Levitt NS, Heckmann JM, 2010. HIV neuropathy in South Africans: frequency, characteristics, and risk factors. Muscle Nerve 41: 599–606.
-
14.
Wadley A, Price P, George J, Affandi J, Smith K, Kamerman P, eds. 2009. HIV-Associated Sensory Neuropathy: A Comparison of Rates and Risk Factors in Australia and South Africa. 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention, July 19–22, 2009, Cape Town, South Africa.
-
15.
Cherry CL, Affandi JS, Imran D, Yunihastuti E, Smyth K, Vanar S, Kamarulzaman A, Price P, 2009. Age and height predict neuropathy risk in patients with HIV prescribed stavudine. Neurology 73: 315–320.
-
16.
Keiser O, Anastos K, Schechter M, Balestre E, Myer L, Boulle A, Bangsberg D, Toure H, Braitstein P, Sprinz E, Nash D, Hosseinipour M, Dabis F, May M, Brinkhof MW, Egger M, 2008. Antiretroviral therapy in resource-limited settings 1996 to 2006: patient characteristics, treatment regimens and monitoring in sub-Saharan Africa, Asia and Latin America. Trop Med Int Health 13: 870–879.
-
17.
Arrighi HM, Hertz-Picciotto I, 1994. The evolving concept of the healthy worker survivor effect. Epidemiology 5: 189–196.
-
18.
Gonzalez-Duarte A, Robinson-Papp J, Simpson DM, 2008. Diagnosis and management of HIV-associated neuropathy. Neurol Clin 26: 821–832.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 455 | 289 | 18 |
| Full Text Views | 329 | 7 | 0 |
| PDF Downloads | 128 | 9 | 0 |
Implementation of a Validated Peripheral Neuropathy Screening Tool in Patients Receiving Antiretroviral Therapy in Mombasa, Kenya
Sapna A. Mehta
Sapna A. Mehta
Division of Infectious Diseases, and Center for AIDS Research, Department of Medicine, New York University School of Medicine, New York, New York; Bomu Medical Centre, Mombasa, Kenya
Search for other papers by Sapna A. Mehta in
Current site
Google Scholar
PubMed
Search for other papers by Sapna A. Mehta in
Current site
Google Scholar
PubMed
Aabid Ahmed
Aabid Ahmed
Division of Infectious Diseases, and Center for AIDS Research, Department of Medicine, New York University School of Medicine, New York, New York; Bomu Medical Centre, Mombasa, Kenya
Search for other papers by Aabid Ahmed in
Current site
Google Scholar
PubMed
Search for other papers by Aabid Ahmed in
Current site
Google Scholar
PubMed
Beatrice W. Kariuki
Beatrice W. Kariuki
Division of Infectious Diseases, and Center for AIDS Research, Department of Medicine, New York University School of Medicine, New York, New York; Bomu Medical Centre, Mombasa, Kenya
Search for other papers by Beatrice W. Kariuki in
Current site
Google Scholar
PubMed
Search for other papers by Beatrice W. Kariuki in
Current site
Google Scholar
PubMed
Swaleh Said
Swaleh Said
Division of Infectious Diseases, and Center for AIDS Research, Department of Medicine, New York University School of Medicine, New York, New York; Bomu Medical Centre, Mombasa, Kenya
Search for other papers by Swaleh Said in
Current site
Google Scholar
PubMed
Search for other papers by Swaleh Said in
Current site
Google Scholar
PubMed
Fanuel Omasete
Fanuel Omasete
Division of Infectious Diseases, and Center for AIDS Research, Department of Medicine, New York University School of Medicine, New York, New York; Bomu Medical Centre, Mombasa, Kenya
Search for other papers by Fanuel Omasete in
Current site
Google Scholar
PubMed
Search for other papers by Fanuel Omasete in
Current site
Google Scholar
PubMed
Megan Mendillo
Megan Mendillo
Division of Infectious Diseases, and Center for AIDS Research, Department of Medicine, New York University School of Medicine, New York, New York; Bomu Medical Centre, Mombasa, Kenya
Search for other papers by Megan Mendillo in
Current site
Google Scholar
PubMed
Search for other papers by Megan Mendillo in
Current site
Google Scholar
PubMed
Maura Laverty
Maura Laverty
Division of Infectious Diseases, and Center for AIDS Research, Department of Medicine, New York University School of Medicine, New York, New York; Bomu Medical Centre, Mombasa, Kenya
Search for other papers by Maura Laverty in
Current site
Google Scholar
PubMed
Search for other papers by Maura Laverty in
Current site
Google Scholar
PubMed
Robert Holzman
Robert Holzman
Division of Infectious Diseases, and Center for AIDS Research, Department of Medicine, New York University School of Medicine, New York, New York; Bomu Medical Centre, Mombasa, Kenya
Search for other papers by Robert Holzman in
Current site
Google Scholar
PubMed
Search for other papers by Robert Holzman in
Current site
Google Scholar
PubMed
Fred Valentine
Fred Valentine
Division of Infectious Diseases, and Center for AIDS Research, Department of Medicine, New York University School of Medicine, New York, New York; Bomu Medical Centre, Mombasa, Kenya
Search for other papers by Fred Valentine in
Current site
Google Scholar
PubMed
Search for other papers by Fred Valentine in
Current site
Google Scholar
PubMed
Sumathi Sivapalasingam
Sumathi Sivapalasingam
Division of Infectious Diseases, and Center for AIDS Research, Department of Medicine, New York University School of Medicine, New York, New York; Bomu Medical Centre, Mombasa, Kenya
Search for other papers by Sumathi Sivapalasingam in
Current site
Google Scholar
PubMed
Search for other papers by Sumathi Sivapalasingam in
Current site
Google Scholar
PubMed
Limited objective data are available for the prevalence of peripheral neuropathy (PN) among antiretroviral (ART)–treated human immunodeficiency virus (HIV)–infected patients in resource-limited settings. A validated neuropathy-screening tool was integrated into routine ART visits at an HIV clinic in Mombasa, Kenya. Diagnosis of PN required at least one symptom and either abnormal vibratory sensation or deep tendon reflex bilaterally. Among 102 consecutively screened patients, 63% were women, 62% were receiving ART for ≤ 1 year, and 86% were receiving a stavudine (D4T)–based regimen. Thirty-seven (36%) had PN. Univariate analysis showed that current D4T use was protective against PN (P = 0.03) and older age was a marginal risk factor (P = 0.05). Multivariate analysis showed that older age was a risk factor for neuropathy (P = 0.04). Peripheral neuropathy was common, particularly among older HIV-infected adults in Kenya. The protective association with current D4T use likely represents survivor effect bias. Longitudinal studies using this screen will help further characterize PN in resource-limited settings.
Author Notes
Financial support: This study was supported in part by grant 1UL1RR029893 from the National Center for Research Resources, National Institutes of Health, grant P30 AI027742 from for the New York University Center for AIDS Research, and cooperative agreement 5U62PS224509-04 from the Centers for Disease Control and Prevention.
Disclosure: The contents of this report are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention.
Authors' addresses: Sapna A. Mehta, Megan Mendillo, Maura Laverty, Robert Holzman, and Sumathi Sivapalasingam, Department of Medicine, New York University School of Medicine, New York, NY. Aabid Ahmed, Beatrice W. Kariuki, Swaleh Said, and Fanuel Omasete, Bomu Medical Centre, Mombasa, Kenya. Fred Valentine, Center for AIDS Research and Department of Medicine, New York University School of Medicine, New York, NY.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Ferrari S, Vento S, Monaco S, Cavallaro T, Cainelli F, Rizzuto N, Temesgen Z, 2006. Human immunodeficiency virus-associated peripheral neuropathies. Mayo Clin Proc 81: 213–219.
-
2.
Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach. Available at: http://www.who.int/hiv/pub/guidelines/artadultguidelines.pdf. Accessed June 2, 2010.
-
3.
Boulle A, Orrel C, Kaplan R, Van Cutsem G, McNally M, Hilderbrand K, Myer L, Egger M, Coetzee D, Maartens G, Wood R, 2007. Substitutions due to antiretroviral toxicity or contraindication in the first 3 years of antiretroviral therapy in a large South African cohort. Antivir Ther 12: 753–760.
-
4.
Forna F, Liechty CA, Solberg P, Asiimwe F, Were W, Mermin J, Behumbiize P, Tong T, Brooks JT, Weidle PJ, 2007. Clinical toxicity of highly active antiretroviral therapy in a home-based AIDS care program in rural Uganda. J Acquir Immune Defic Syndr 44: 456–462.
-
5.
Hawkins C, Achenbach C, Fryda W, Ngare D, Murphy R, 2007. Antiretroviral durability and tolerability in HIV-infected adults living in urban Kenya. J Acquir Immune Defic Syndr 45: 304–310.
-
6.
Hoffmann CJ, Fielding KL, Charalambous S, Sulkowski MS, Innes C, Thio CL, Chaisson RE, Churchyard GJ, Grant AD, 2008. Antiretroviral therapy using zidovudine, lamivudine, and efavirenz in South Africa: tolerability and clinical events. AIDS 22: 67–74.
-
7.
Millogo A, Lankoande D, Yameogo I, Yameogo AA, Sawadogo AB, 2008. Polyneuropathies in patients treated with HAART in Bobo-Dioulasso hospital, Burkina Faso [in French]. Bull Soc Pathol Exot 101: 11–13.
-
8.
van Oosterhout JJ, Bodasing N, Kumwenda JJ, Nyirenda C, Mallewa J, Cleary PR, de Baar MP, Schuurman R, Burger DM, Zijlstra EE, 2005. Evaluation of antiretroviral therapy results in a resource-poor setting in Blantyre, Malawi. Trop Med Int Health 10: 464–470.
-
9.
Wester CW, Kim S, Bussmann H, Avalos A, Ndwapi N, Peter TF, Gaolathe T, Mujugira A, Busang L, Vanderwarker C, Cardiello P, Johnson O, Thior I, Mazonde P, Moffat H, Essex M, Marlink R, 2005. Initial response to highly active antiretroviral therapy in HIV-1C-infected adults in a public sector treatment program in Botswana. J Acquir Immune Defic Syndr 40: 336–343.
-
10.
Cherry CL, Wesselingh SL, Lal L, McArthur JC, 2005. Evaluation of a clinical screening tool for HIV-associated sensory neuropathies. Neurology 65: 1778–1781.
-
11.
Simpson DM, Kitch D, Evans SR, McArthur JC, Asmuth DM, Cohen B, Goodkin K, Gerschenson M, So Y, Marra CM, Diaz-Arrastia R, Shriver S, Millar L, Clifford DB, 2006. HIV neuropathy natural history cohort study: assessment measures and risk factors. Neurology 66: 1679–1687.
-
12.
WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children. Available at: http://www.who.int/hiv/pub/guidelines/HIVstaging150307.pdf. Accessed June 2, 2010.
-
13.
Maritz J, Benatar M, Dave JA, Harrison TB, Badri M, Levitt NS, Heckmann JM, 2010. HIV neuropathy in South Africans: frequency, characteristics, and risk factors. Muscle Nerve 41: 599–606.
-
14.
Wadley A, Price P, George J, Affandi J, Smith K, Kamerman P, eds. 2009. HIV-Associated Sensory Neuropathy: A Comparison of Rates and Risk Factors in Australia and South Africa. 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention, July 19–22, 2009, Cape Town, South Africa.
-
15.
Cherry CL, Affandi JS, Imran D, Yunihastuti E, Smyth K, Vanar S, Kamarulzaman A, Price P, 2009. Age and height predict neuropathy risk in patients with HIV prescribed stavudine. Neurology 73: 315–320.
-
16.
Keiser O, Anastos K, Schechter M, Balestre E, Myer L, Boulle A, Bangsberg D, Toure H, Braitstein P, Sprinz E, Nash D, Hosseinipour M, Dabis F, May M, Brinkhof MW, Egger M, 2008. Antiretroviral therapy in resource-limited settings 1996 to 2006: patient characteristics, treatment regimens and monitoring in sub-Saharan Africa, Asia and Latin America. Trop Med Int Health 13: 870–879.
-
17.
Arrighi HM, Hertz-Picciotto I, 1994. The evolving concept of the healthy worker survivor effect. Epidemiology 5: 189–196.
-
18.
Gonzalez-Duarte A, Robinson-Papp J, Simpson DM, 2008. Diagnosis and management of HIV-associated neuropathy. Neurol Clin 26: 821–832.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 455 | 289 | 18 |
| Full Text Views | 329 | 7 | 0 |
| PDF Downloads | 128 | 9 | 0 |