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Acute Arboviral Infections in Guinea, West Africa, 2006

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  • Department of Tropical Medicine, Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; Centre International de Recherche sur le Infections Tropicales, N'Zérékoré, Guinea

Acute febrile illnesses comprise the majority of the human disease burden in sub-Saharan Africa. We hypothesized that arboviruses comprised a considerable proportion of undiagnosed febrile illnesses in Guinea and sought to determine the frequency of arboviral disease in two hospitals there. Using a standard case definition, 47 suspected cases were detected in approximately 4 months. Immunoglobulin M antibody capture enzyme-linked immunosorbent assays and plaque-reduction neutralization assays revealed that 63% (30/47) of patients were infected with arboviruses, including 11 West Nile, 2 yellow fever, 1 dengue, 8 chikungunya, and 5 Tahyna infections. Except for yellow fever, these are the first reported cases of human disease from these viruses in Guinea and the first reported cases of symptomatic Tahyna infection in Africa. These results strongly suggest that arboviruses circulate and are common causes of disease in Guinea. Improving surveillance and laboratory capacity for arbovirus diagnoses will be integral to understanding the burden posed by these agents in the region.

Author Notes

*Address correspondence to Emily S. Jentes, Epidemic Intelligence Service, Office of Workforce and Career Development, and Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, GA 30333. E-mail: ejentes@cdc.gov

Financial support: This work was supported, in part, by Tulane University Department of Tropical Medicine and CDC Cooperative Agreement Grant T01/CCT622308-02 and the Louisiana Vaccine Center and the South Louisiana Institute for Infectious Disease Research sponsored by the Louisiana Board of Regents.

Authors' addresses: Emily S. Jentes, Epidemic Intelligence Service, Office of Workforce and Career Development and Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, GA, E-mail: ejentes@cdc.gov. Jaimie Robinson, Barbara W. Johnson, Jennifer Iverson, and Shanna Beecher, Division of Vector Borne Infectious Disease, Centers for Disease Control and Prevention, Fort Collins, CO. Ibrahima Conde, Yosse Sakouvougui, M. Alpha Bah, Fousseny Diakite, and Mamadi Coulibaly, Centre International de Recherche sur le Infections Tropicale, N'Zérékoré Regional Hospital, N'Zérékoré, Guinea. Daniel G. Bausch, Department of Tropical Medicine, Tulane School of Public Health and Tropical Medicine, New Orleans, LA.

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