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Preliminary Characterization of Mus musculus–Derived Pathogenic Strains of Leptospira borgpetersenii Serogroup Ballum in a Hamster Model

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  • Centro de Biotecnologia and Departamento de Microbiologia e Parasitologia, Universidade Federal de Pelotas Pelotas, Rio Grande do Sul, Brazil; Centro de Biotecnologia, Instituto Butantan, São Paulo, São Paulo, Brazil

Human and animal leptospirosis caused by Leptospira spp. belonging to serogroup Ballum has increased worldwide in the past decade. We report the isolation and serologic and molecular characterization of four L. borgpetersenii serogroup Ballum isolates obtained from Mus musculus, and preliminary virulence studies. These isolates are useful for diagnosis of leptospirosis and for epidemiologic studies of its virulence and pathogenic mechanisms.

Author Notes

*Address correspondence to Éverton F. da Silva, Centro de Biotecnologia, Universidade Federal de Pelotas, Caixa Postal 354, CEP 96010-900, Pelotas, Rio Grande do Sul, Brazil. E-mail: efsilva@ufpel.edu.br

Financial support: The study was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico.

Authors' addresses: Éverton F. da Silva, Samuel R. Félix, Michel Q. Fagundes, Amilton C. P. S. Neto, André A. Grassmann, Marta G. Amaral, and Odir A. Dellagostin, Centro de Biotecnologia, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil, E-mails: efsilva@ufpel.edu.br, samuelrf@gmail.com, michelquevedofagundes@yahoo.com.br, amiltonseixas@gmail.com, grassmann.aa@gmail.com, amaral@ufpel.edu.br, and odir@ufpel.edu.br. Gustavo M. Cerqueira, Centro de Biotecnologia, Instituto Butantan, São Paulo, Brazil, E-mail: cerqueiragm@yahoo.com.br. Tiago Gallina, Departamento de Microbiologia e Parasitologia, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil, E-mail: tiagogallina@gmail.com.

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