Looareesuwan S, 1992. Overview: pathophysiology and management of cerebral malaria. Southeast Asian J Trop Med Public Health 23 (Suppl 4): 155–165.
Patel CC, 1971. Acute febrile encephalopathy in Ugandan children. Afr J Med Sci 2: 127–134.
Looareesuwan S, Phillips RE, White NJ, Kietinun S, Karbwang J, Rackow C, Turner RC, Warrell DA, 1985. Quinine and severe falciparum malaria in late pregnancy. Lancet 2: 4–8.
Warrell DA, Molyneux ME, Beales PF, 1990. Severe and complicated malaria. Trans Roy Soc Trop Med Hyg 84 (Suppl 2): 1–65.
Hemmer CJ, Kern P, Holst FG, Nawroth PP, Dietrich M, 1991. Neither heparin nor acetylsalicylic acid influence the clinical course in human Plasmodium falciparum malaria: a prospective randomized study. Am J Trop Med Hyg 45: 608–612.
Schönhöfer P, Offerhaus L, Herxheimer A, 2003. Dipyrone and agranulocytosis: what is the risk? Lancet Mar 361: 968–969.
Schwartz JI, Chan CC, Mukhopadhyay S, McBride KJ, Jones TM, Adcock S, Moritz C, Hedges J, Grasing K, Dobratz D, Cohen RA, Davidson MH, Bachmann KA, Gertz BJ, 1999. Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans. Clin Pharmacol Ther 65: 653–660.
Bernard GR, Wheeler AP, Russell JA, Schein R, Summer WR, Steinberg KP, Fulkerson WJ, Wright PE, Christman BW, Dupont WD, Higgins SB, Swindell BB, 1997. The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med 336: 912–918.
Jegerschöld C, Pawelzik SC, Purhonen P, Bhakat P, Gheorghe KR, Gyobu N, Mitsuoka K, Morgenstern R, Jakobsson PJ, Herbert H, 2008. Structural basis for induced formation of the inflammatory mediator prostaglandin E2. Proc Natl Acad Sci USA 105: 11110–11115.
Bone RC, Slotman G, Maunder R, Silverman H, Hyers TM, Kerstein MD, Ursprung JJ, 1989. Randomized double-blind, multicenter study of prostaglandin E1 in patients with the adult respiratory distress syndromes. Prostaglandin E1 Study Group. Chest 96: 114–119.
Haupt MT, Jastremski MS, Clemmer TP, Metz CA, Goris GB, 1991. Effect of ibuprofen in patients with severe sepsis: a randomized, double-blind, multicenter study. The Ibuprofen Study Group. Crit Care Med 19: 1339–1347.
World Health Organization, Communicable Diseases Cluster, 2000. Severe falciparum malaria. Trans R Soc Trop Med Hyg 94 (Suppl 1): S1–S90.
Silachamroon U, Krudsood S, Thanachartwet W, Tangpukdee N, Leowattana W, Chalermrut K, Srivilairit S, Wilaiaratana P, Thimasarn K, Looareesuwan S, 2005. An open, randomized trial of three-day treatment with artesunate combined with a standard dose of mefloquine divided over either two or three days, for acute, uncomplicated falciparum malaria. Southeast Asian J Trop Med Public Health 36: 591–596.
Tangpukdee N, Krudsood S, Thanachartwet W, Chalermrut K, Pengruksa C, Srivilairit S, Silachamroon U, Wilairatana P, Phongtananant S, Kano S, Looareesuwan S, 2005. An open randomized clinical trial of Artekin vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria. Southeast Asian J Trop Med Public Health 36: 1085–1091.
Krudsood S, Tangpukdee N, Thanchatwet V, Wilairatana P, Srivilairit S, Pothipak N, Jianping S, Guoqiao L, Brittenham GM, Looareesuwan S, 2007. Dose ranging studies of new artemisinin-piperaquine fixed combinations compared to standard regimens of artemisisnin combination therapies for acute uncomplicated falciparum malaria. Southeast Asian J Trop Med Public Health 38: 971–978.
World Health Organization, 1973. Chemotherapy of malaria and resistance to antimalarials. Report of a WHO scientific group. World Health Organ Tech Rep Ser 529: 30–36.
Krishna S, Pukrittayakamee S, Supanaranond W, ter Kuile F, Supputamangkol Y, Attatamsoonthorn K, Ruprah M, White NJ, 1995. Fever in uncomplicated Plasmodium falciparum malaria: randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment. Trans R Soc Trop Med Hyg 89: 507–509.
Matsiégui PB, Missinou MA, Necek M, Mavoungou E, Issifou S, Lell B, Kremsner PG, 2008. Antipyretic effect of ibuprofen in Gabonese children with uncomplicated falciparum malaria: a randomized, double-blind, placebo-controlled trial. Malar J 7: 91.
Brandts CH, Ndjave M, Graninger W, Kremsner PG, 1997. Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria. Lancet 350: 704–709.
Hugosson E, Montgomery SM, Premji Z, Troye-Blomberg M, Björkman A, 2006. Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes. Acta Trop 99: 75–82.
Kwiatkowski D, Molyneux ME, Stephens S, Curtis N, Klein N, Pointaire P, Smit M, Allan R, Brewster DR, Grau GE, Greenwood BM. 1993. Anti-TNF therapy inhibits fever in cerebral malaria. Q J Med 86: 91–98.
van Hensbroek MB, Palmer A, Onyiorah E, Schneider G, Jaffar S, Dolan G, Memming H, Frenkel J, Enwere G, Bennett S, Kwiatkowski D, Greenwood B, 1996. The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria. J Infect Dis 174: 1091–1097.
Looareesuwan S, Sjostrom L, Krudsood S, Wilairatana P, Porter RS, Hills F, Warrell DA, 1999. Polyclonal anti-tumor necrosis factor-alpha Fab used as an ancillary treatment for severe malaria. Am J Trop Med Hyg 61: 26–33.
Kwiatkowski D, 1989. Febrile temperatures can synchronize the growth of Plasmodium falciparum in vitro. J Exp Med 169: 357–361.
Kwiatkowski D, 1995 Malarial toxins and the regulation of parasite density. Parasitol Today 11: 206–212.
Kwiatkowski D, 1993. TNF-inducing malaria toxin: a sheep in wolf's clothing? Ann Trop Med Parasitol 87: 613–616.
McGuire W, D'Alessandro U, Stephens S, Olaleye BO, Langerock P, Greenwood BM, Kwiatkowski D, 1998. Levels of tumour necrosis factor and soluble TNF receptors during malaria fever episodes in the community. Trans R Soc Trop Med Hyg 92: 50–53.
Matsiegui PB, Missinou MA, Issifou S, Necek M, Mavoungou E, 2007. Ibuprofen does not affect levels of tumor necrosis factor alpha and soluble tumor necrosis factor receptor types I and II in Gabonese children with uncomplicated Plasmodium falciparum malaria. Eur Cytokine Netw 18: 201–205.
Kwiatkowski D, Molyneux ME, Stephens S, Curtis N, Klein N, Pointaire P, Smit M, Allan R, Brewster DR, Grau GE, Greenwood BM, 1993. Anti-TNF therapy inhibits fever in cerebral malaria. Q J Med 86: 91–98.
Qiu HB, Pan JQ, Zhao YQ, Chen DC, 1997. Effects of dexamethasone and ibuprofen on LPS-induced gene expression of TNF alpha, IL-1 beta, and MIP-1 alpha in rat lung. Zhongguo Yao Li Xue Bao 18: 165–168.
Cazanave S, Vadrot N, Tinel M, Berson A, Lettéron P, Larosche I, Descatoire V, Feldmann G, Robin MA, Pessayre D, 2008. Ibuprofen administration attenuates serum TNF-alpha levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation. Toxicol Appl Pharmacol 231: 336–343.
Udomsangpetch R, Pipitaporn B, Silamut K, Pinches R, Kyes S, Looareesuwan S, Newbold C, White NJ, 2002. Febrile temperatures induce cytoadherence of ring-stage Plasmodium falciparum-infected erythrocytes. Proc Natl Acad Sci USA 99: 11825–11829.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 1684 | 1592 | 789 |
Full Text Views | 379 | 16 | 6 |
PDF Downloads | 147 | 15 | 4 |
Because some febrile patients are unable to swallow or retain oral antipyretic drugs, we carried out a double-blind, placebo-controlled trial in which intravenous ibuprofen (IV-ibuprofen) was given to adults hospitalized with fever associated with acute uncomplicated falciparum malaria treated with oral artesunate plus mefloquine. Thirty patients received IV-ibuprofen 400 mg and 30 received placebo every 6 hours for 72 hours. Reduction in the area above 37.0°C versus time curve was significantly greater for IV-ibuprofen than for placebo during the first 72 hours after first administration. No patients developed severe malaria; parasite clearance was delayed in the patients whose fevers were controlled by IV-ibuprofen (median 37.3 hours versus 23.7 hours in the placebo group [P = 0.0024]). This difference did not appear to be clinically important Adverse events, none considered severe, occurred equally in both groups. IV-ibuprofen was effective and well tolerated in reducing fever in febrile inpatients with malaria.
Financial support: This study and its report were supported by Cumberland Pharmaceuticals Inc. (Nashville, TN), which had a role in the study design, data acquisition, statistical analyses, and the decision to publish the findings. However, the authors had complete access to all study data and autonomy as to the report's final content.
Disclosure: DAW's visits to the study site were sponsored by Cumberland Pharmaceuticals.
Authors' addresses: Srivicha Krudsood, Department of Tropical Hygiene, Mahidol University, Bangkok, Thailand. Noppadon Tangpukdee and Polrat Wilairatana, Department of Clinical Tropical Medicine, Mahidol University, Bangkok, Thailand. Nantaporn Pothipak and Chatnapa Duangdee, Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. David A. Warrell, Nuffield Department of Clinical Medicine, University of Oxford, UK.
Looareesuwan S, 1992. Overview: pathophysiology and management of cerebral malaria. Southeast Asian J Trop Med Public Health 23 (Suppl 4): 155–165.
Patel CC, 1971. Acute febrile encephalopathy in Ugandan children. Afr J Med Sci 2: 127–134.
Looareesuwan S, Phillips RE, White NJ, Kietinun S, Karbwang J, Rackow C, Turner RC, Warrell DA, 1985. Quinine and severe falciparum malaria in late pregnancy. Lancet 2: 4–8.
Warrell DA, Molyneux ME, Beales PF, 1990. Severe and complicated malaria. Trans Roy Soc Trop Med Hyg 84 (Suppl 2): 1–65.
Hemmer CJ, Kern P, Holst FG, Nawroth PP, Dietrich M, 1991. Neither heparin nor acetylsalicylic acid influence the clinical course in human Plasmodium falciparum malaria: a prospective randomized study. Am J Trop Med Hyg 45: 608–612.
Schönhöfer P, Offerhaus L, Herxheimer A, 2003. Dipyrone and agranulocytosis: what is the risk? Lancet Mar 361: 968–969.
Schwartz JI, Chan CC, Mukhopadhyay S, McBride KJ, Jones TM, Adcock S, Moritz C, Hedges J, Grasing K, Dobratz D, Cohen RA, Davidson MH, Bachmann KA, Gertz BJ, 1999. Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans. Clin Pharmacol Ther 65: 653–660.
Bernard GR, Wheeler AP, Russell JA, Schein R, Summer WR, Steinberg KP, Fulkerson WJ, Wright PE, Christman BW, Dupont WD, Higgins SB, Swindell BB, 1997. The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med 336: 912–918.
Jegerschöld C, Pawelzik SC, Purhonen P, Bhakat P, Gheorghe KR, Gyobu N, Mitsuoka K, Morgenstern R, Jakobsson PJ, Herbert H, 2008. Structural basis for induced formation of the inflammatory mediator prostaglandin E2. Proc Natl Acad Sci USA 105: 11110–11115.
Bone RC, Slotman G, Maunder R, Silverman H, Hyers TM, Kerstein MD, Ursprung JJ, 1989. Randomized double-blind, multicenter study of prostaglandin E1 in patients with the adult respiratory distress syndromes. Prostaglandin E1 Study Group. Chest 96: 114–119.
Haupt MT, Jastremski MS, Clemmer TP, Metz CA, Goris GB, 1991. Effect of ibuprofen in patients with severe sepsis: a randomized, double-blind, multicenter study. The Ibuprofen Study Group. Crit Care Med 19: 1339–1347.
World Health Organization, Communicable Diseases Cluster, 2000. Severe falciparum malaria. Trans R Soc Trop Med Hyg 94 (Suppl 1): S1–S90.
Silachamroon U, Krudsood S, Thanachartwet W, Tangpukdee N, Leowattana W, Chalermrut K, Srivilairit S, Wilaiaratana P, Thimasarn K, Looareesuwan S, 2005. An open, randomized trial of three-day treatment with artesunate combined with a standard dose of mefloquine divided over either two or three days, for acute, uncomplicated falciparum malaria. Southeast Asian J Trop Med Public Health 36: 591–596.
Tangpukdee N, Krudsood S, Thanachartwet W, Chalermrut K, Pengruksa C, Srivilairit S, Silachamroon U, Wilairatana P, Phongtananant S, Kano S, Looareesuwan S, 2005. An open randomized clinical trial of Artekin vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria. Southeast Asian J Trop Med Public Health 36: 1085–1091.
Krudsood S, Tangpukdee N, Thanchatwet V, Wilairatana P, Srivilairit S, Pothipak N, Jianping S, Guoqiao L, Brittenham GM, Looareesuwan S, 2007. Dose ranging studies of new artemisinin-piperaquine fixed combinations compared to standard regimens of artemisisnin combination therapies for acute uncomplicated falciparum malaria. Southeast Asian J Trop Med Public Health 38: 971–978.
World Health Organization, 1973. Chemotherapy of malaria and resistance to antimalarials. Report of a WHO scientific group. World Health Organ Tech Rep Ser 529: 30–36.
Krishna S, Pukrittayakamee S, Supanaranond W, ter Kuile F, Supputamangkol Y, Attatamsoonthorn K, Ruprah M, White NJ, 1995. Fever in uncomplicated Plasmodium falciparum malaria: randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment. Trans R Soc Trop Med Hyg 89: 507–509.
Matsiégui PB, Missinou MA, Necek M, Mavoungou E, Issifou S, Lell B, Kremsner PG, 2008. Antipyretic effect of ibuprofen in Gabonese children with uncomplicated falciparum malaria: a randomized, double-blind, placebo-controlled trial. Malar J 7: 91.
Brandts CH, Ndjave M, Graninger W, Kremsner PG, 1997. Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria. Lancet 350: 704–709.
Hugosson E, Montgomery SM, Premji Z, Troye-Blomberg M, Björkman A, 2006. Relationship between antipyretic effects and cytokine levels in uncomplicated falciparum malaria during different treatment regimes. Acta Trop 99: 75–82.
Kwiatkowski D, Molyneux ME, Stephens S, Curtis N, Klein N, Pointaire P, Smit M, Allan R, Brewster DR, Grau GE, Greenwood BM. 1993. Anti-TNF therapy inhibits fever in cerebral malaria. Q J Med 86: 91–98.
van Hensbroek MB, Palmer A, Onyiorah E, Schneider G, Jaffar S, Dolan G, Memming H, Frenkel J, Enwere G, Bennett S, Kwiatkowski D, Greenwood B, 1996. The effect of a monoclonal antibody to tumor necrosis factor on survival from childhood cerebral malaria. J Infect Dis 174: 1091–1097.
Looareesuwan S, Sjostrom L, Krudsood S, Wilairatana P, Porter RS, Hills F, Warrell DA, 1999. Polyclonal anti-tumor necrosis factor-alpha Fab used as an ancillary treatment for severe malaria. Am J Trop Med Hyg 61: 26–33.
Kwiatkowski D, 1989. Febrile temperatures can synchronize the growth of Plasmodium falciparum in vitro. J Exp Med 169: 357–361.
Kwiatkowski D, 1995 Malarial toxins and the regulation of parasite density. Parasitol Today 11: 206–212.
Kwiatkowski D, 1993. TNF-inducing malaria toxin: a sheep in wolf's clothing? Ann Trop Med Parasitol 87: 613–616.
McGuire W, D'Alessandro U, Stephens S, Olaleye BO, Langerock P, Greenwood BM, Kwiatkowski D, 1998. Levels of tumour necrosis factor and soluble TNF receptors during malaria fever episodes in the community. Trans R Soc Trop Med Hyg 92: 50–53.
Matsiegui PB, Missinou MA, Issifou S, Necek M, Mavoungou E, 2007. Ibuprofen does not affect levels of tumor necrosis factor alpha and soluble tumor necrosis factor receptor types I and II in Gabonese children with uncomplicated Plasmodium falciparum malaria. Eur Cytokine Netw 18: 201–205.
Kwiatkowski D, Molyneux ME, Stephens S, Curtis N, Klein N, Pointaire P, Smit M, Allan R, Brewster DR, Grau GE, Greenwood BM, 1993. Anti-TNF therapy inhibits fever in cerebral malaria. Q J Med 86: 91–98.
Qiu HB, Pan JQ, Zhao YQ, Chen DC, 1997. Effects of dexamethasone and ibuprofen on LPS-induced gene expression of TNF alpha, IL-1 beta, and MIP-1 alpha in rat lung. Zhongguo Yao Li Xue Bao 18: 165–168.
Cazanave S, Vadrot N, Tinel M, Berson A, Lettéron P, Larosche I, Descatoire V, Feldmann G, Robin MA, Pessayre D, 2008. Ibuprofen administration attenuates serum TNF-alpha levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation. Toxicol Appl Pharmacol 231: 336–343.
Udomsangpetch R, Pipitaporn B, Silamut K, Pinches R, Kyes S, Looareesuwan S, Newbold C, White NJ, 2002. Febrile temperatures induce cytoadherence of ring-stage Plasmodium falciparum-infected erythrocytes. Proc Natl Acad Sci USA 99: 11825–11829.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 1684 | 1592 | 789 |
Full Text Views | 379 | 16 | 6 |
PDF Downloads | 147 | 15 | 4 |