Ladhani S, Lowe B, Cole AO, Kouwondo K, Newton CR, 2002. Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome. Br J Haematol 119: 839–847.
Wickramasinghe SN, Abdalla SH, 2000. Blood and bone marrow in malaria. Best Pract Res Clin Haematol 13: 277–299.
Taha K, El-Dein SZ, Idrees M, Makboul G, Baidas G, 2007. Haematological changes in malaria in relation to Plasmodium species. Kuwait Med J 39: 262–267.
Gerardin P, Roger C, Ka AS, Jouvencel P, Brousse V, Imbert P, 2002. Prognostic value of thrombocytopenia in African children with falciparum malaria. Am J Trop Med Hyg 66: 686–691.
Taylor TE, Fu WN, Carr RA, Whitten RO, Mueller JG, Fosiko NM, Liomba NG, Molyneux ME, 2004. Differentiating the pathologies of cerebral malaria by post mortem parasite counts. Nat Med 10: 143–145.
Beare NA, Taylor TE, Harding SP, Lewallen S, Molyneux ME, 2006. Malarial retinopathy: a newly established diagnostic sign in severe malaria. Am J Trop Med Hyg 75: 790–797.
Kelton JG, Keystone J, Denomme G, Tozman E, Glynn M, Neame PB, Gauldie J, Jewen J, 1983. Immune-mediated thrombocytopenia of malaria. J Clin Invest 71: 832–836.
Kreil A, Wenisch C, Brittenham G, Looreesvwan S, Peck-Radosavljevic M, 2000. Thrombopoietin in Plasmodium falciparum malaria. Br J Haematol 109: 534–536.
Mwangi TW, Ross A, Snow RW, Marsh K, 2005. Case definitions of clinical malaria under different transmission conditions in Kilifi District, Kenya. J Infect Dis 191: 1932–1939.
Smith T, Charwood JD, Kihonda J, Mwankusye S, Billingsley P, Meuwissen J, Lyimo E, Takken W, Teuscher T, Tanner M, 1993. Absence of seasonal variation in malaria parasitaemia in an area of intense seasonal transmission. Acta Trop 54: 55–72.
Wassmer SC, Combes V, Grau GE, 2003. Pathophysiology of cerebral malaria: role of host cells in the modulation of cytoadhesion. Ann N Y Acad Sci 992: 30–38.
Grau E, Mackenzie CD, Carr RA, Redard M, Pizzolato G, Allasia C, Cataldo C, Taylor TE, Molyneux ME, 2003. Platelet accumulation in brain microvessels in fatal paediatric cerebral malaria. J Infect Dis 187: 461–466.
Molyneux ME, Taylor TE, Wirima JJ, Borgstein A, 1989. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med 71: 441–459.
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We conducted this study to determine the prognostic significance of the platelet count in children with cerebral malaria. We studied children with cerebral malaria admitted to the pediatric research ward at Queen Elizabeth Central Hospital, Malawi. We analyzed 1,811 children with cerebral malaria and compared them with 521 children with bacterial meningitis. There was a significant difference in platelet counts between children with cerebral malaria and those with meningitis. Among children with cerebral malaria, there was no relationship between the platelet count and either the admission coma score or the eventual outcome. Those with malarial retinopathy were more thrombocytopenic than those without. Our results suggest that the platelet count is not prognostic in Malawian children with cerebral malaria.
Authors' addresses: Yamikani Chimalizeni and Kondwani Kawaza, Department of Paediatrics, College of Medicine, Blantyre, Malawi. Terrie Taylor, Blantyre Malaria Project, Blantyre, Malawi. Malcolm Molyneux, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi, E-mail: mmolyneux999@googlemail.com.
Ladhani S, Lowe B, Cole AO, Kouwondo K, Newton CR, 2002. Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome. Br J Haematol 119: 839–847.
Wickramasinghe SN, Abdalla SH, 2000. Blood and bone marrow in malaria. Best Pract Res Clin Haematol 13: 277–299.
Taha K, El-Dein SZ, Idrees M, Makboul G, Baidas G, 2007. Haematological changes in malaria in relation to Plasmodium species. Kuwait Med J 39: 262–267.
Gerardin P, Roger C, Ka AS, Jouvencel P, Brousse V, Imbert P, 2002. Prognostic value of thrombocytopenia in African children with falciparum malaria. Am J Trop Med Hyg 66: 686–691.
Taylor TE, Fu WN, Carr RA, Whitten RO, Mueller JG, Fosiko NM, Liomba NG, Molyneux ME, 2004. Differentiating the pathologies of cerebral malaria by post mortem parasite counts. Nat Med 10: 143–145.
Beare NA, Taylor TE, Harding SP, Lewallen S, Molyneux ME, 2006. Malarial retinopathy: a newly established diagnostic sign in severe malaria. Am J Trop Med Hyg 75: 790–797.
Kelton JG, Keystone J, Denomme G, Tozman E, Glynn M, Neame PB, Gauldie J, Jewen J, 1983. Immune-mediated thrombocytopenia of malaria. J Clin Invest 71: 832–836.
Kreil A, Wenisch C, Brittenham G, Looreesvwan S, Peck-Radosavljevic M, 2000. Thrombopoietin in Plasmodium falciparum malaria. Br J Haematol 109: 534–536.
Mwangi TW, Ross A, Snow RW, Marsh K, 2005. Case definitions of clinical malaria under different transmission conditions in Kilifi District, Kenya. J Infect Dis 191: 1932–1939.
Smith T, Charwood JD, Kihonda J, Mwankusye S, Billingsley P, Meuwissen J, Lyimo E, Takken W, Teuscher T, Tanner M, 1993. Absence of seasonal variation in malaria parasitaemia in an area of intense seasonal transmission. Acta Trop 54: 55–72.
Wassmer SC, Combes V, Grau GE, 2003. Pathophysiology of cerebral malaria: role of host cells in the modulation of cytoadhesion. Ann N Y Acad Sci 992: 30–38.
Grau E, Mackenzie CD, Carr RA, Redard M, Pizzolato G, Allasia C, Cataldo C, Taylor TE, Molyneux ME, 2003. Platelet accumulation in brain microvessels in fatal paediatric cerebral malaria. J Infect Dis 187: 461–466.
Molyneux ME, Taylor TE, Wirima JJ, Borgstein A, 1989. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med 71: 441–459.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 980 | 926 | 694 |
Full Text Views | 351 | 12 | 6 |
PDF Downloads | 106 | 11 | 4 |