Optimism, Persistence, and Our Collective Crystal Ball

Thomas E. Wellems Member, American Society of Tropical Medicine and Hygiene

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Author Notes

*Address correspondence to Thomas E. Wellems, c/o Administrative Director, ASTMH Headquarters, 111 Deer Lake Road, Suite 100, The Sherwood Group, Deerfield, IL 60015. E-mail: thomas.wellems@verizon.net

Disclosure: Presented as the Presidential Address at the 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Washington, DC, November 21, 2009.

  • 1.

    Wellems TE, Josephs R, 1979. Crystallization of deoxyhemoglobin S by fiber alignment and fusion. J Mol Biol 135: 651674.

  • 2.

    Wellems TE, Vassar RJ, Josephs R, 1981. Polymorphic assemblies of double strands of sickle cell hemoglobin. Manifold pathways of deoxyhemoglobin S crystallization. J Mol Biol 153: 10111026.

    • Search Google Scholar
    • Export Citation
  • 3.

    Judson HT, 1995. The Eighth Day of Creation: Makers of a Revolution in Biology. New York: Penguin Books.

  • 4.

    Crowther JG, 1974. The Cavendish Laboratory 1874–1974. New York: Science History Publications.

  • 5.

    Thomas JM, 2004. Max Perutz. Proc Am Philos Soc 148: 235241.

  • 6.

    Ferry G, 2007. Max Perutz and the Secret of Life. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.

  • 7.

    Perutz MF, 1949. Recent developments in the x-ray study of haemoglobin. Roughton FJW, Kendrew JC, eds. Haemoglobin: A Symposium Based on a Conference Held at Cambridge in June 1948 in Memory of Sir Joseph Barcroft. London: Butterworths Scientific Publications, 135147.

    • Search Google Scholar
    • Export Citation
  • 8.

    Perutz MF, 1992. Protein Structure: New Approaches to Diseases and Therapy. New York: W.H. Freeman and Company.

  • 9.

    Perutz MF, 1970. Stereochemistry of cooperative effects in haemoglobin. Nature 228: 726734.

  • 10.

    Perutz MF, Lehmann H, 1968. Molecular pathology of human haemoglobin. Nature 219: 902909.

  • 11.

    Research Collaboratory for Structural Bioinformatics, 2008. Annual Report. Available at: http://www.pdb.org. Accessed September 17, 2009.

    • Search Google Scholar
    • Export Citation
  • 12.

    Nollert P, Feese MD, Staker BL, Kim H, 2005. Protein x-ray crystallography in drug discovery. Gad SC, ed. Drug Discovery Handbook (Pharmaceutical Development Series). Hoboken, NJ: Wiley-Interscience.

    • Search Google Scholar
    • Export Citation
  • 13.

    Ingram VM, 2002. The birth of molecular biology: how biophysicists and biochemists in the 1950s shaped a new science. Nature 419: 669670.

    • Search Google Scholar
    • Export Citation
  • 14.

    Perutz MF, 1996. By what right do we invoke human rights? Proc Am Philos Soc 140: 135147.

  • 15.

    Stokes DE, 1997. Pasteur's Quadrant: Basic Science and Technological Innovation. Washington, DC: The Brookings Institution.

  • 16.

    Morel CM, 2008. Research, development and innovation on neglected diseases: a developing country perspective. 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene. Commemorative Fund Lecture, December 9, 2008, New Orleans, LA.

    • Search Google Scholar
    • Export Citation
  • 17.

    Bush V, 1945. Science—the Endless Frontier. Available at: http://www.nsf.gov/od/lpa/nsf50/vbush1945.htm. Accessed November 12, 2009.

  • 18.

    Pasteur L, 1872. Pourquoi le goût de la vendange diffère de celui du raisin. Vallery-Radot LP, ed. Oeuvres de Pasteur. Tome III. Études sur le Vinaigre et sur le Vin (1924). Paris: Masson (publicly available at: http://gallica.bnf.fr/), 461464.

    • Search Google Scholar
    • Export Citation
  • 19.

    Pasteur L, 1871. Pourquoi la France n'a pas trouvé d'hommes supérieurs au moment du péril. Vallery-Radot LP, ed. Oeuvres de Pasteur. Tome VII. Mélanges Scientifiques et Littéraires (1939). Paris: Masson (publicly available at: http://gallica.bnf.fr/), 211221.

    • Search Google Scholar
    • Export Citation
  • 20.

    Pais A, 1991. Niels Bohr's Times, in Physics, Philosophy, and Polity. Oxford: Clarendon Press.

  • 21.

    de Hevesy G, 1944. Some applications of isotopic indicators: Nobel lecture, December 12, 1944. Available at: http://nobelprize.org/nobel_prizes/chemistry/laureates/1943/hevesy-lecture.pdf. Accessed November 12, 2009.

    • Search Google Scholar
    • Export Citation
  • 22.

    Enea V, Ellis J, Zavala F, Arnot DE, Asavanich A, Masuda A, Quakyi I, Nussenzweig RS, 1984. DNA cloning of Plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope. Science 225: 628630.

    • Search Google Scholar
    • Export Citation
  • 23.

    Dame JB, Williams JL, McCutchan TF, Weber JL, Wirtz RA, Hockmeyer WT, Maloy WL, Haynes JD, Schneider I, Roberts D et al., 1984. Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science 225: 593599.

    • Search Google Scholar
    • Export Citation
  • 24.

    Wellems TE, Howard RJ, 1986. Homologous genes encode two distinct histidine-rich proteins in a cloned isolate of Plasmodium falciparum. Proc Natl Acad Sci USA 83: 60656069.

    • Search Google Scholar
    • Export Citation
  • 25.

    Maniatis T, Fritsch EF, Sambrook J, 1982. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.

  • 26.

    Bohr N, 1932. Light and life (Pt. 1). Nature 133: 421423.

  • 27.

    Bohr N, 1932. Light and life (Pt. 2). Nature 133: 457459.

  • 28.

    Segrè G, 2007. Faust in Copenhagen: A Struggle for the Soul of Physics. New York: Penguin Group, 266269.

  • 29.

    McKaughan DJ, 2005. The influence of Niels Bohr on Max Delbrück: revisiting the hopes inspired by “light and life”. Isis 96: 507529.

    • Search Google Scholar
    • Export Citation
  • 30.

    Delbrück M, 1969. A physicist's renewed look at biology–twenty years later: Nobel lecture, December 10, 1969. Available at: http://nobelprize.org/nobel_prizes/medicine/laureates/1969/delbruck-lecture.html. Accessed November 12, 2009.

    • Search Google Scholar
    • Export Citation
  • 31.

    Obama B, 2009. Remarks by the President at the National Academy of Sciences Annual Meeting, April 27, 2009. Available at: http://www.whitehouse.gov/the_press_office/Remarks-by-the-President-at-the-National-Academy-of-Sciences-Annual-Meeting/. Accessed November 12, 2009.

    • Search Google Scholar
    • Export Citation
  • 32.

    Committee on a New Biology for the 21st Century, 2009. A New Biology for the 21st Century: Ensuring the United States Leads the Coming Biology Revolution. Washington, DC: The National Academies Press. Available at: http://www.nap.edu/catalog/12764.html. Accessed November 9, 2009.

    • Search Google Scholar
    • Export Citation
  • 33.

    Fermi G, Perutz MF, Shaanan B, Fourme R, 1984. The crystal structure of human deoxyhaemoglobin at 1.74 A resolution. J Mol Biol 175: 159174.

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