Arevalo-Herrera M, Herrera S, 2001. Plasmodium vivax malaria vaccine development. Mol Immunol 38: 443–455.
Bruce MC, Galinski MR, Barnwell JW, Snounou G, Day KP, 1999. Polymorphism at the merozoite surface protein-3α locus of Plasmodium vivax: global and local diversity. Am J Trop Med Hyg 61: 518–525.
Rayner JC, Corredor V, Feldman D, Ingravallo P, Iderabdullah F, Galinski MR, Barnwell JW, 2002. Extensive polymorphism in the Plasmodium vivax merozoite surface coat protein MSP-3α is limited to specific domains. Parasitology 125: 393–405.
Galinski MR, Corredor-Medina CC, Povoa M, Crosby J, Ingravallo P, Barnwell JW, 1999. Plasmodium vivax merozoite surface protein-3 contains coiled-coil motifs in an alanine-rich central domain. Mol Biochem Parasitol 101: 131–147.
Galinski MR, Ingravallo P, Corredor-Medina C, Al-Khedery B, Povoa M, Barnwell JW, 2001. Plasmodium vivax merozoite surface proteins-3beta and-3gamma share structural similarities with P. vivax merozoite surface protein-3alpha and define a new gene family. Mol Biochem Parasitol 115: 41–53.
Bruce MC, Galinski MR, Barnwell JW, Donnelly CA, Walmsley M, Alpers MP, Walliker D, Day KP, 2000. Genetic diversity and dynamics of Plasmodium falciparum and P. vivax populations in multiply infected children with asymptomatic malaria infections in Papua New Guinea. Parasitology 121: 257–272.
Cui L, Mascorro CN, Fan Q, Rzomp KA, Khuntirat B, Zhou G, Chen H, Yan G, Sattabongkot J, 2003. Genetic diversity and multiple infections of Plasmodium vivax malaria in western Thailand. Am J Trop Med Hyg 68: 613–619.
Korea Center for Disease Control and Prevention, 2008. 2008 Guidelines for Malaria Control. Seoul: Korea Center for Disease Control and Prevention, 52.
Han ET, Song TE, Park JH, Shin EH, Guk SM, Kim TY, Chai JY, 2004. Allelic dimorphism in the merozoite surface protein-3α in Korean isolates of Plasmodium vivax. Am J Trop Med Hyg 71: 745–749.
|Past two years||Past Year||Past 30 Days|
|Full Text Views||241||116||1|
Nucleotide sequence analysis of the Plasmodium vivax PvMSP-3α gene was conducted on blood from 143 malaria patients admitted to Korea University Medical Center from 1996 to 2007 in the Republic of Korea (ROK). From 1996 to 2002, the PvMSP-3α alleles were of two types, SKOR-67 (2.53 kb) and SKOR-69 (1.78 kb), which differed in length and amino acid sequence. Two new variants with similar size to SKOR-67 were first observed in 2002 and in 2006–2007 accounted for nearly 50% (25/51) of the sampled isolates. The new variants had the same amino acid sequence as SKOR-69 in the N-terminal region, but in Blocks I and II and in the C-terminal region, they were similar to previously reported isolates from Thailand, Papua New Guinea, India, Brazil, and Ecuador strains.
Financial support: Partial funding for this project was provided by the Military Infectious Diseases Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD, and the Center for Health Promotion and Preventive Medicine, Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD.
Authors' addresses: Deok Hwa Nam, Myoung Hyun Nam, and Chae Seung Lim, Department of Laboratory Medicine, Brain Korea 21 Graduate School of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea, E-mail: email@example.com. Jun Seo Oh, Laboratory of Cellular Oncology, Brain Korea 21 Graduate School of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. Hae Chul Park, Laboratory of Neurodevelopment, Brain Korea 21 Graduate School of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. Won Ja Lee, Laboratory of Medical Entomology, Korean Center for Disease Control and Prevention, Ministry of Health and Welfare, Seoul, Republic of Korea. Jetsumon Sattabongkot, Department of Entomology, Armed Forces Institute of Medical Sciences–United States Army Military Component, Bangkok, Thailand. Terry A. Klein, Force Health Protection, 65th Medical Brigade, Unit 15281, Seoul, Korea. Francisco J. Ayala, Department of Ecology and Evolutionary Biology, University of California, Irvine, CA.
Reprint requests: Chae Seung Lim, Department of Laboratory Medicine, College of Medicine, Korea University Ansan Hospital, 516, Gojan Dong, Ansan City, Gyoenggi Province, Republic of Korea, 425-707, E-mail: firstname.lastname@example.org, Tel: +82-31-412-5300, Fax: +82-31-412-5314.