Hospital-Based Surveillance for Japanese Encephalitis at Four Sites in Bangladesh, 2003–2005

M. Jahangir Hossain International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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Emily S. Gurley International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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Susan Montgomery International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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Lyle Petersen International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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James Sejvar International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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Marc Fischer International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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Amanda Panella International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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Ann M. Powers International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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Nazmun Nahar International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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A. K. M. Rafique Uddin International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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M. Ekhlasur Rahman International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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A. R. M. Saifuddin Ekram International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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Stephen P. Luby International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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Robert F. Breiman International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh; Centers for Disease Control and Prevention, Atlanta, Georgia; Dhaka Medical College Hospital, Dhaka, Bangladesh; Mymensingh Medical College Hospial, Mymensingh, Bangladesh; MAG Osmani Medical College Hospital, Sylhet, Bangladesh; Rajshahi Medical College Hospital, Rajshahi, Bangladesh

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DOI:
https://doi.org/10.4269/ajtmh.2010.09-0125
Volume/Issue:
Volume 82: Issue 2
Page(s):
344–349
Restricted access
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We investigated the epidemiology and etiology of encephalitis at four tertiary hospitals in Bangladesh during 2003–2005. Patients who met a clinical case definition for acute encephalitis and had cerebrospinal fluid (CSF) pleocytosis were eligible for enrollment; a standardized sampling pattern was used to enroll eligible patients. Recent Japanese encephalitis virus (JEV) infection was defined by presence of IgM antibodies against JEV in CSF or serum. Twenty (4%) of 492 cases had laboratory evidence of recent JEV infection; two died. All JE cases occurred during May–December, and cases were identified among all age groups. All cases resided in rural areas. Fifteen patients were re-assessed 4–6 weeks after hospitalization; 5 (33%) patients had physical disabilities and 7 (47%) reported cognitive difficulties. Infection with JEV is clearly an etiology of encephalitis in Bangladesh. Population-based studies to quantify burden of disease could assess options for targeted immunization programs.

Author Notes

*Address correspondence to M. Jahangir Hossain, Clinical Sciences Division, International Centre for Diarrhoeal Disease Research, 68 Shaheed Tajuddin, Ahmed Sarani Mohakhali, Dhaka 1212, Bangladesh. E-mail: jhossain@icddrb.org

Financial support: This study was supported by the Centers for Disease Control and Prevention.

Authors' addresses: M. Jahangir Hossain, Emily S. Gurley, and Robert F. Breiman, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, E-mails: jhossain@icddrb.org, egurley@icddrb.org, and rbreiman@ke.cdc.gov. Susan Montgomery, Lyle Petersen, James Sejvar, Marc Fischer, Amanda Panella, and Ann M. Powers, Centers for Disease Control and Prevention, Atlanta, GA, E-mails: zqu6@cdc.gov, lxp2@cdc.gov, zea3@cdc.gov, mxf2@cdc.gov, ahf6@cdc.gov, and akp7@cdc.gov. Nazmun Nahar and A. K. M. Rafique Uddin, Dhaka Medical College Hospital, Dhaka, Bangladesh, E-mails: nahar@dab-bd.org and rudduin-bsm@yahoo.com. M. Ekhlasur Rahman, Mymensingh Medical College Hospital, Myemsingh, Bangladesh and MAG Osmani Medical College Hospital, Sylhet, Bangladesh, E-mail: pediatrics_03@yahoo.com. A. R. M. Saifuddin Ekram, Rajshahi Medical College Hospital, Rajshahi, Bangladesh, E-mail: armsekram@yahoo.com. Stephen P. Luby, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh and Centers for Disease Control and Prevention, Atlanta, GA, E-mail: sluby@icddrb.org.

Copyright:
© The American Society of Tropical Medicine and Hygiene 2010
Received:
11 Mar 2009
|
Accepted:
01 Sep 2009
|
Published Online:
05 Feb 2010
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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