Familial Analysis of Seropositivity to Trypanosoma cruzi and of Clinical Forms of Chagas Disease

Roseane L. Silva-Grecco Disciplina de Genética, Disciplina de Doenças Infecciosas e Parasitárias, Disciplina de Imunologia, Federal University of the Triângulo Mineiro, Uberaba, Minas Gerais, Brazil

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Marly A. S. Balarin Disciplina de Genética, Disciplina de Doenças Infecciosas e Parasitárias, Disciplina de Imunologia, Federal University of the Triângulo Mineiro, Uberaba, Minas Gerais, Brazil

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Dalmo Correia Disciplina de Genética, Disciplina de Doenças Infecciosas e Parasitárias, Disciplina de Imunologia, Federal University of the Triângulo Mineiro, Uberaba, Minas Gerais, Brazil

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Aluízio Prata Disciplina de Genética, Disciplina de Doenças Infecciosas e Parasitárias, Disciplina de Imunologia, Federal University of the Triângulo Mineiro, Uberaba, Minas Gerais, Brazil

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Virmondes Rodrigues Jr. Disciplina de Genética, Disciplina de Doenças Infecciosas e Parasitárias, Disciplina de Imunologia, Federal University of the Triângulo Mineiro, Uberaba, Minas Gerais, Brazil

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A cross-sectional study was carried out in Água Comprida, MG, Brazil, a region previously endemic to Chagas disease whose vectorial transmission was interrupted around 20 year ago. A total of 998 individuals were examined for anti-Trypanosoma cruzi antibodies. Seropositivity was observed in 255 subjects (25.5%), and 743 subjects were negative. Forty-one families with 5–80 individuals with similar environmental conditions were selected for familial analysis. In 15 families, seropositivity to T. cruzi was observed in > 50% of individuals. The segregation analysis confirmed family aggregation for the seropositivity to the T. cruzi. Heart commitment was the major clinical form observed, and in six families, > 50% of the individuals display cardiopathy that may be attributed to T. cruzi infection. Our results support the hypothesis that there is a family aggregation for the seropositivity but without the effect of one major gene.

Author Notes

*Address correspondence to Dalmo Correia, Filho Disciplina de Doenças Infecciosas e Parasitárias, Universidade Federal do Triângulo Mineiro Caixa, Postal 118 38001-970, Uberaba, Minas Gerais, Brasil. E-mail: dalmo@mednet.com.br

Authors' addresses: Roseane L. Silva-Grecco and Marly A. S. Balarin, Disciplina de Genética, Federal University of the Triângulo Mineiro, Uberaba, Minas Gerais, Brazil, E-mails: rlope@terra.com.br and balarin@mednet.com.br. Dalmo Correia and Aluízio Prata, Disciplina de Doenças Infecciosas e Parasitárias, Federal University of the Triângulo Mineiro, Uberaba, Minas Gerais, Brazil, E-mail: dalmo@mednet.com.br. Virmondes R. Rodrigues Jr., Disciplina de Imunologia, Federal University of the Triângulo Mineiro, Uberaba, Minas Gerais, Brazil, E-mail: vrodrigues@mednet.com.br.

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