Autochthonous Visceral Leishmaniasis in a Human Immunodeficiency Virus (HIV)-Infected Patient: The First in Thailand and Review of the Literature

Chusana Suankratay Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;Department of Medicine and Division of Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

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Gompol Suwanpimolkul Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;Department of Medicine and Division of Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

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Henry Wilde Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;Department of Medicine and Division of Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

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Padet Siriyasatien Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;Department of Medicine and Division of Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

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We report a case of visceral leishmaniasis in a human immunodeficiency virus (HIV)-infected 37-year-old Thai fisherman who presented with nephritonephrotic syndrome, fever, anemia, and thrombocytopenia. Bone marrow biopsy revealed many amastigotes within macrophages. Kidney biopsy showed membranoproliferative glomerulonephritis. Polymerase chain reaction (PCR) and nucleotide sequence analysis of the internal transcribed spacer 1 of the small subunit ribosomal RNA gene in blood and kidney biopsy specimens showed Leishmania species previously described in a Thai patient with visceral leishmaniasis. Only four autochthonous cases of leishmaniasis have been reported in Thailand since 1996. To the best of our knowledge, this is the first report of autochthonous visceral leishmaniasis in an HIV-infected Thai. With an increasing number of patients with autochthonous leishmaniasis in association with the presence of potential vector, it remains to be determined whether this vector-borne disease will become an emerging infectious disease in Thailand.

Author Notes

*Address correspondence to Chusana Suankratay, Division of Infectious Diseases, Department of Medicine, Chulalongkorn University Hospital, Bangkok, 10330, Thailand. E-mail: chusana.s@chula.ac.th

Disclaimer: All authors have no conflicts of interest to declare and all have actively contributed to this study and review.

Authors' addresses: Chusana Suankratay and Gompol Suwanpimolkul, Division of Infectious Diseases, Department of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand, E-mail: chusana.s@chula.ac.th. Henry Wilde, Department of Medicine and Division of Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Padet Siriyasatien, Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

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