HIV Protease Inhibitors, Indinavir or Nelfinavir, Augment Antimalarial Action of Artemisinin in vitro

Lokesh C. Mishra Department of Zoology, University of Delhi, Delhi, India

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Amit Bhattacharya Department of Zoology, University of Delhi, Delhi, India

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Manish Sharma Department of Zoology, University of Delhi, Delhi, India

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Virendra K. Bhasin Department of Zoology, University of Delhi, Delhi, India

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Most malaria endemic regions are co-infested with HIV infection. Treatment of one may affect outcome of the other in co-infected individuals. HIV protease inhibitors, indinavir or nelfinavir, are important antiretroviral drugs and artemisinin is central to malaria treatment. We show these protease inhibitors augment the antimalarial activity of artemisinin against P. falciparum in vitro.

Author Notes

*Address correspondence to Virendra K. Bhasin, Department of Zoology, University of Delhi, North Campus, Delhi-110007, India. E-mail: virendrabhasin@hotmail.com
† These authors contributed equally to this work.

Financial support: This work was supported in part by the Department of Biotechnology, Ministry of Science and Technology, Government of India and University of Delhi, Delhi. LCM and MS received fellowship from the CSIR and UGC, New Delhi, respectively. AB received support from Ramjas College, North Campus, and University of Delhi.

Authors' addresses: Lokesh C. Mishra, Amit Bhattacharya, Manish Sharma, and Virendra K. Bhasin, Department of Zoology, University of Delhi, Delhi, India, E-mails: lokesh20sept@yahoo.co.in, amit4dec@yahoo.com, manish24jan@yahoo.co.in, and virendrabhasin@hotmail.com.

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