World Health Organization, 2006 Guidelines for the Treatment of Malaria. Geneva: World Health Organization. WHO/HTM/RBM 2006.1108.
Massougbodji A, Kone M, Kinde-Gazard D, Same-Ekobo A, Cambon N, Mueller EA, 2002 A randomized, double-blind study on the efficacy and safety of a practical three-day regimen with artesunate and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in Africa. Trans R Soc Trop Med Hyg 96: 655–659.
Agomo PU, Meremikwu MM, Watila IM, Omalu IJ, Odey FA, Oguche S, Ezeiru VI, Aina OO, 2008 Efficacy, safety and tolerability of artesunate-mefloquine in the treatment of uncomplicated Plasmodium falciparum malaria in four geographic zones of Nigeria. Malar J 7: 172.
Ndiaye JL, Faye B, Diouf A, Kuété T, Cisse M, Seck PA, Brasseur P, Same-Ekobo A, Lameyre V, Gaye O, 2008 Randomized, comparative study of the efficacy and safety of artesunate plus amodiaquine, administered as a single daily intake versus two daily intakes in the treatment of uncomplicated falciparum malaria. Malar J 7: 16.
World Health Organization, 2000 Management of Severe Malaria: A Practical Handbook. Second Edition. Geneva: WHO.
World Health Organization, 1999 Management of Severe Malnutrition: A Manual for Physicians and Other Senior Health Workers. Geneva: WHO.
World Health Organization, 2003 Assessment and Monitoring of Antimalarial Drug Efficacy for the Treatment of Uncomplicated Falciparum Malaria. Geneva: World Health Organization. WHO/HTM/RBM/2003.50.
Faye B, Ndiaye JL, Dieng Y, Faye O, Gaye O, 2007 Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal. Malar J 6: 80.
Sagara I, Dicko A, Djimde A, Guindo O, Kone M, Tolo Y, Thera MA, Sogoba M, Fofana M, Ouattara A, Sissoko M, Jansen HF, Doumbo OK, 2008 A randomized trial of artesunate-mefloquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Mali. Am J Trop Med Hyg 79: 655–661.
Valecha N, Srivastava P, Mohanty SS, Mittra P, Sharma SK, Tyagi PK, Pradhan K, Dev V, Singh R, Dash AP, Sharma YD, 2009 Therapeutic efficacy of artemether-lumefantrine in uncomplicated falciparum malaria in India. Malar J 8: 107.
Hutagalung R, Paiphun L, Ashley EA, McGready R, Brockman A, Thwai KL, Singhasivanon P, Jelinek T, White NJ, Nosten FH, 2005 A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand. Malar J 4: 46.
Nosten F, van Vugt M, Price R, Luxemburger C, Thway KL, Brockman A, Mcgready R, ter Kuile F, Looaresuwan S, White NJ, 2000 Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Lancet 356: 297–302.
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An open randomized clinical trial study was carried out to compare efficacy and tolerability of artesunate mefloquine 25 mg/kg body weight (Artequin paediatric) versus artemether lumefantrine (Coartem) in the treatment of uncomplicated Plasmodium falciparum malaria in children. In each arm, 160 patients were assigned to receive either AS + MQ or AL with 28 days follow-up. The adequate clinical and parasitological response at Day 28 for per protocol analysis was after polymerase chain reaction correction, 100% for AS + MQ and 96.8% for AL. In the intention-to-treat analysis, the respective cure rates were 96.2% for AS + MQ and 93.7% for AL. No serious adverse events (AEs) were reported. The most frequent AE was vomiting, 30% in AS + MQ arm and 36% in AL arm. No biological significant abnormal values related to the study drug have been reported. The new pediatric artesunate mefloquine formulated in granule fixed dose combination is well adapted to children in Africa.
Financial support: The investigations were financially supported by Pharmaceutical lab MEPHA, West Africa. They also supplied the antimalarial drugs used for this study.
Authors' addresses: Babacar Faye, Jean Louis Ndiaye, Roger Tine, Khadim Sylla, Ali Gueye, Aminata Colle Lô, and Oumar Gaye, Department of Parasitology, Faculty of Medicine, University Cheikh Anta Diop, Dakar, Senegal, E-mails: bfaye67@yahoo.fr, jlndiaye@yahoo.com, rogertine@hotmail.com, khadimesylla@yahoo.fr, and ogaye@refer.sn.
Reprint requests: Oumar Gaye, Department of Parasitology, Faculty of Medicine, University Cheikh Anta Diop, PO Box 5005, Dakar, Senegal, E-mail: ogaye@refer.sn.
World Health Organization, 2006 Guidelines for the Treatment of Malaria. Geneva: World Health Organization. WHO/HTM/RBM 2006.1108.
Massougbodji A, Kone M, Kinde-Gazard D, Same-Ekobo A, Cambon N, Mueller EA, 2002 A randomized, double-blind study on the efficacy and safety of a practical three-day regimen with artesunate and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in Africa. Trans R Soc Trop Med Hyg 96: 655–659.
Agomo PU, Meremikwu MM, Watila IM, Omalu IJ, Odey FA, Oguche S, Ezeiru VI, Aina OO, 2008 Efficacy, safety and tolerability of artesunate-mefloquine in the treatment of uncomplicated Plasmodium falciparum malaria in four geographic zones of Nigeria. Malar J 7: 172.
Ndiaye JL, Faye B, Diouf A, Kuété T, Cisse M, Seck PA, Brasseur P, Same-Ekobo A, Lameyre V, Gaye O, 2008 Randomized, comparative study of the efficacy and safety of artesunate plus amodiaquine, administered as a single daily intake versus two daily intakes in the treatment of uncomplicated falciparum malaria. Malar J 7: 16.
World Health Organization, 2000 Management of Severe Malaria: A Practical Handbook. Second Edition. Geneva: WHO.
World Health Organization, 1999 Management of Severe Malnutrition: A Manual for Physicians and Other Senior Health Workers. Geneva: WHO.
World Health Organization, 2003 Assessment and Monitoring of Antimalarial Drug Efficacy for the Treatment of Uncomplicated Falciparum Malaria. Geneva: World Health Organization. WHO/HTM/RBM/2003.50.
Faye B, Ndiaye JL, Dieng Y, Faye O, Gaye O, 2007 Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal. Malar J 6: 80.
Sagara I, Dicko A, Djimde A, Guindo O, Kone M, Tolo Y, Thera MA, Sogoba M, Fofana M, Ouattara A, Sissoko M, Jansen HF, Doumbo OK, 2008 A randomized trial of artesunate-mefloquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Mali. Am J Trop Med Hyg 79: 655–661.
Valecha N, Srivastava P, Mohanty SS, Mittra P, Sharma SK, Tyagi PK, Pradhan K, Dev V, Singh R, Dash AP, Sharma YD, 2009 Therapeutic efficacy of artemether-lumefantrine in uncomplicated falciparum malaria in India. Malar J 8: 107.
Hutagalung R, Paiphun L, Ashley EA, McGready R, Brockman A, Thwai KL, Singhasivanon P, Jelinek T, White NJ, Nosten FH, 2005 A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand. Malar J 4: 46.
Nosten F, van Vugt M, Price R, Luxemburger C, Thway KL, Brockman A, Mcgready R, ter Kuile F, Looaresuwan S, White NJ, 2000 Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Lancet 356: 297–302.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 567 | 399 | 17 |
Full Text Views | 362 | 9 | 4 |
PDF Downloads | 142 | 12 | 4 |