Rausch RL, Wilson JF, Schantz PM, McMahon BJ, 1987. Spontaneous death of Echinococcus multilocularis: cases diagnosed serologically (by Em2 ELISA) and clinical significance. Am J Trop Med Hyg 36: 576–585.
Vogel H, 1978. How does the alveolar echinococcus grow? [in German]. Tropenmed Parasitol 29: 1–11.
Rausch R, 1954. Studies on the helminth fauna of Alaska. XX. The histogenesis of the alveolar larva of Echinococcus species. J Infect Dis: 94 178–186.
Vogel H, 1977. On Echinococcus multilocularis in southern Germany II. Development of the larval stages and histopathological reactions in common vole, Microtus arvalis [in German]. Tropenmed Parasitol: 28 409–427.
Eckert J, Thompson RC, Mehlhorn H, 1983. Proliferation and metastases formation of larval Echinococcus multilocularis. I. Animal model, macroscopical and histological findings. Z Parasitenkd: 69 737–748.
Mehlhorn H, Eckert J, Thompson RC, 1983. Proliferation and metastases formation of larval Echinococcus multilocularis. II. Ultrastructural investigations. Z Parasitenkd: 69 749–763.
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In this study we present, for the first time, a three-dimensional digital reconstruction of Echinococcus multilocularis larval growth in human tissue. Formalin-fixed, paraffin-embedded hepatic tissues from patients with alveolar echinococcosis were serially sectioned, stained, and areas of larval growth of the parasite were microphotographed. Parasitic structures were reconstructed from multiple digital planes, revealing a root-like network of interconnected vesicles and tubules extending into the periphery of lesions.
Authors' addresses: Dennis Tappe and Matthias Frosch, Institute of Hygiene and Microbiology, University of Würzburg, Würzburg, Germany, E-mails: dtappe@hygiene.uni-wuerzburg.de and mfrosch@hygiene.uni-wuerzburg.de. Stephan Zidowitz, Fraunhofer MEVIS Institute for Medical Image Computing, Bremen, Germany, E-mail: stephan.zidowitz@mevis.fraunhofer.de. Philipp Demmer, Institute of Pathology, University of Würzburg, Würzburg, Germany, E-mail: phdemmer@gmx.de. Peter Kern, Comprehensive Infectious Diseases Center, Division of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center Ulm, Ulm, Germany, E-mail: peter.kern@uniklinik-ulm.de. Thomas F. E. Barth, Institute of Pathology, University Hospital and Medical Center Ulm, Ulm, Germany, E-mail: thomas.barth@uniklinik-ulm.de.
Rausch RL, Wilson JF, Schantz PM, McMahon BJ, 1987. Spontaneous death of Echinococcus multilocularis: cases diagnosed serologically (by Em2 ELISA) and clinical significance. Am J Trop Med Hyg 36: 576–585.
Vogel H, 1978. How does the alveolar echinococcus grow? [in German]. Tropenmed Parasitol 29: 1–11.
Rausch R, 1954. Studies on the helminth fauna of Alaska. XX. The histogenesis of the alveolar larva of Echinococcus species. J Infect Dis: 94 178–186.
Vogel H, 1977. On Echinococcus multilocularis in southern Germany II. Development of the larval stages and histopathological reactions in common vole, Microtus arvalis [in German]. Tropenmed Parasitol: 28 409–427.
Eckert J, Thompson RC, Mehlhorn H, 1983. Proliferation and metastases formation of larval Echinococcus multilocularis. I. Animal model, macroscopical and histological findings. Z Parasitenkd: 69 737–748.
Mehlhorn H, Eckert J, Thompson RC, 1983. Proliferation and metastases formation of larval Echinococcus multilocularis. II. Ultrastructural investigations. Z Parasitenkd: 69 749–763.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 347 | 298 | 86 |
Full Text Views | 349 | 10 | 6 |
PDF Downloads | 78 | 9 | 4 |