Levett PN, 2007. Sequence-based typing of Leptospira: epidemiology in the genomic era. PLoS Negl Trop Dis 1 :e120.
Ko AI, Galvão Reis M, Ribeiro Dourado CM, Johnson WD Jr, Riley LW, 1999. Urban epidemic of severe leptospirosis in Brazil. Salvador Leptospirosis Study Group. Lancet 354 :820–825.
Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, Levett PN, Gilman RH, Willig MR, Gotuzzo E, Vinetz JM; Peru-United States Leptospirosis Consortium, 2003. Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis 3 :757–771.
Epsein PR, Calix O, Blanco J, 1995. Climate and disease in Colombia. Lancet 346 :1243–1244.
Sebek Z, Sixl W, Valova M, Marth E, Dock M, Reinthaler FF, 1989. Serological investigations for leptospirosis in humans in Columbia. Geogr Med Suppl 3 :51–60.
Ferro BE, Rodriguez AL, Perez M, Travi BL, 2006. Seroprevalence of Leptospira infection in habitants of peripheral neighborhoods in Cali, Colombia. Biomedica (Bogota) 26 :250–257.
Agudelo-Flórez P, Restrepo BN, Arboleda M, 2007. Situación de la leptospirosis en el Urabá antioqueño colombiano: estudio seroepidemiológico y factores de riesgo en población general urbana. Cad Saude Publica 23 :2094–2102.
Levett PN, Morey RE, Galloway RL, Turner DE, Steigerwalt AG, Mayer LW, 2005. Detection of pathogenic leptospires by real-time quantitative PCR. J Med Microbiol 54 :45–49.
Giraldo de León G, Orrego A, Betancurth M, 2002. Los roedores como reservorios de leptospiras en planteles porcinos de la zona central cafetera de Colombia. Arch Med Vet 34 :69–78.
Morales GA, Guzmán VH, Beltrán LE, 1978. Leptospirosis in Colombia: isolation of Leptospira spp. from the kidneys of brown rats (Rattus norvegicus) trapped on infected piggeries. Trop Anim Health Prod 10 :121–123.
Faria MT, Calderwood MS, Athanazio DA, McBride AJA, Hartskeerl RA, Pereira MM, Ko AI, Reis MG, 2008. Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil. Acta Trop 108 :1–5.
Arango J, Cittadino E, Agostini A, Dorta de Mazzonelli G, Alvarez C, Colusi M, Koval A, Cabrera A, Kravetz F, 2001. Prevalencia de leptospiras en Rattus rattus y Rattus norvegicus en el Gran Buenos Aires, Argentina. Ecologia Austral 11 :25–30.
Natarajaseenivasan K, Ratnam S, 1997. Experimental leptospirosis in laboratory mice and rats. J Commun Dis 29 :291–293.
Riley LW, Ko AI, Unger A, Reis MG, 2007. Slum health: diseases of neglected populations. BMC Int Health Hum Rights 7 :2.
Reis RB, Ribeiro GS, Felzemburgh RD, Santana FS, Mohr S, Melendez AX, Queiroz A, Santos AC, Ravines RR, Tassinari WS, Carvalho MS, Reis MG, Ko AI, 2008. Impact of environment and social gradient on leptospira infection in urban slums. PLoS Negl Trop Dis 23 :e228.
|Past two years||Past Year||Past 30 Days|
|Full Text Views||512||205||5|
Leptospirosis is a widely distributed zoonosis, and rats are its most common source of infection. Our goal was to determine the frequency for Leptospira infection in rodents in a farmers market in the city of Medellin. We performed a descriptive transversal study sampling 254 rodents. Rodents were bled and killed, and kidneys samples were taken. Supernatants of macerated kidneys were cultured on Fletcher medium. Microagglutination tests (MATs) with 11 serovars were also carried out in rat serum, and a polymerase chain reaction (PCR) specific for pathogenic species was used to test each bacterial culture. All animals were identified as Rattus norvegicus; 25% and 20% were positive by MAT and culture, respectively. PCR tests of 12 isolates were positive for pathogenic serovars, and 4 of them were confirmed as L. interrogans by sequencing. These data show the role of this natural carrier and shedder of pathogenic leptospires in the epidemiology of urban leptospirosis in Colombia.