Interleukin-1 Beta Single-Nucleotide Polymorphism’s C Allele is Associated with Elevated Risk of Gastric Cancer in Helicobacter pylori-Infected Peruvians

Sebastian Gehmert Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Billie Velapatiño Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Phabiola Herrera Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Jaqueline Balqui Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Livia Santivañez Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Jaime Cok Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Gloria Vargas Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Juan Combe Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Douglas J. Passaro Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Sijin Wen Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Frank Meyer Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Douglas E. Berg Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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Robert H. Gilman Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Surgery, Otto-von-Guericke University, Magdeburg, Germany; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias, Universidad Peruana Cayetano Heredia, Lima, Peru; Asociacion Benefica PRISMA, Department of Bioresearch, Lima, Peru; Department of Pathology, Hospital Nacional Cayetano Heredia, Lima, Peru; Department of Gastroenterology, National Major San Marcos University, Lima, Peru; Department of Gastroenterology, National Institute of Neoplastic Diseases, Lima, Peru; Division of Epidemiology and Biostatistics, University of Illinois School of Public Health, Chicago, Illinois; Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Departments of Molecular Microbiology, Genetics, and Medicine, Washington University Medical School, St. Louis, Missouri; Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

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DOI:
https://doi.org/10.4269/ajtmh.2009.08-0494
Volume/Issue:
Volume 81: Issue 5
Page(s):
804–810
Restricted access
Get Permissions

Particular alleles of the interleukin-1B (IL-1B) gene have been correlated with increased risk of atrophic gastritis and gastric cancer in the populations of East Asia and Europe. No such data exist from Peru, a developing country with a population genotypically different from others studied and with a high prevalence of Helicobacter pylori infection and gastric cancer. We conducted a case-control study comparing 334 hospitalized patients with atrophic gastritis or gastric cancer with 158 nonatrophic gastritis patients (controls). Conditional logistic regression analysis revealed that an increased risk of atrophic gastritis (odds ratio, 5.60) and gastric cancer (odds ratio, 2.36) was associated with the IL-1B-511 C allele. Our study is the first to establish this allele as a risk for these conditions. Given the high prevalence of H. pylori and recurrence rate after treatment, IL-1B-511 single-nucleotide polymorphism analysis may identify those individuals who would benefit most from robust H. pylori eradication efforts in Peru.

Author Notes

Reprint requests: Sebastian Gehmert, Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, 7435 Fannin Street, Houston, TX 77054, E-mail: s.gehmert@gmail.com. Robert H. Gilman, Department of International Health, The Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, E-mail: RGilman@jhsph.edu.
Copyright:
Copyright 2009 The American Society of Tropical Medicine 2009
Received:
24 Sep 2008
|
Accepted:
14 Jul 2009
|
Published Online:
Nov 2009
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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