• 1

    Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, Levett PN, Gilman RH, Willig MR, Gotuzzo E, Vinetz JM; Peru-United States Leptospirosis Consortium, 2003. Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis 3 :757–771.

    • Search Google Scholar
    • Export Citation
  • 2

    Ellis RD, Fukuda MM, McDaniel P, Welch K, Nisalak A, 2006. Causes of fever in adults on the Thai-Myanmar border. Am J Trop Med Hyg 74 :108–113.

    • Search Google Scholar
    • Export Citation
  • 3

    Levett PN, 2001. Leptospirosis. Clin Microbiol Rev 14 :296–326.

  • 4

    Suttinont C, Losuwanaluk K, Niwatayakul K, Hoontrakul S, Intaranongpai W, Silpasakorn S, Suwancharoen D, Panlar P, Saisongkorh W, Rolain JM, Raoult D, Suputtamongkol Y, 2006. Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study. Ann Trop Med Parasitol 100 :363–370.

    • Search Google Scholar
    • Export Citation
  • 5

    Tangkanakul W, Smits HL, Jatanasen S, Ashford DA, 2005. Leptospirosis: an emerging health problem in Thailand. Southeast Asian J Trop Med Public Health 36 :281–288.

    • Search Google Scholar
    • Export Citation
  • 6

    Levett PN, 2003. Usefulness of serologic analysis as a predictor of the infecting serovar in patients with severe leptospirosis. Clin Infect Dis 36 :447–452.

    • Search Google Scholar
    • Export Citation
  • 7

    Thaipadungpanit J, Wuthiekanun V, Chierakul W, Smythe LD, Petkanchanapong W, Limpaiboon R, Apiwatanaporn A, Slack AT, Suputtamongkol Y, White NJ, Feil EJ, Day NP, Peacock SJ, 2007. Emergence of a virulent clone of Leptospira interrogans as the cause of an epidemic of human leptospirosis in Thailand. PLoS Negl Trop Dis 1 :e56.

    • Search Google Scholar
    • Export Citation
  • 8

    Bureau of Epidemiology Department of Disease Control, Ministry of Public Health, Leptospirosis. Case Definition for Surveillance. ICD-10: A 27. Available at: http://203.157.15.4/publish/cdsur/BEWARE/Leptospirosis.htm. Accessed 2000.

  • 9

    Faine S, Adler B, Bolin C, Perolat P, 1999. Leptospira and Leptospirosis, 2nd Edition. Melbourne, Australia: MediSci.

  • 10

    Stallman N, 1984. International Committee on Systematic Bacteriology, Subcommittee on the Taxonomy of Leptospira: minutes of the meeting, 6 to 10 August 1982, Boston, Massachusetts. Int J Syst Bacteriol 34 :258–259.

    • Search Google Scholar
    • Export Citation

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

The Microscopic Agglutination Test (MAT) Is an Unreliable Predictor of Infecting Leptospira Serovar in Thailand

View More View Less
  • 1 WHO/FAO/OIE Collaborating Centre for Reference and Research on Leptospirosis, Western Pacific Region, Communicable Disease Unit, Queensland Health Scientific Services, Brisbane, Australia; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Medical Department, Udon Thani Reginal Hospital, Udon Thani, Thailand

A prospective study in Thailand identified 106 patients with culture-proven leptospirosis. The accuracy of the microscopic agglutination test (MAT) in predicting the infecting serovar was evaluated in 78/106 (74%) patients with a diagnostic titer. MAT correctly determined the infecting serovar in 26 cases (33%), indicating that this assay is a poor predictor of infecting serovar in our setting.

Author Notes

Reprint requests: Vanaporn Wuthiekanun, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand, E-mail: lek@tropmedres.ac.
Save