Comparison of Prednisolone Plus Albendazole with Prednisolone Alone for Treatment of Patients with Eosinophilic Meningitis

Verajit Chotmongkol Department of Medicine, and Department of Parasitology, Faculty of Medicine, and Department of Biostatistics and Demography, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand; Loei Hospital, Ministry of Public Health, Loei, Thailand

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Suvicha Kittimongkolma Department of Medicine, and Department of Parasitology, Faculty of Medicine, and Department of Biostatistics and Demography, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand; Loei Hospital, Ministry of Public Health, Loei, Thailand

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Kanigar Niwattayakul Department of Medicine, and Department of Parasitology, Faculty of Medicine, and Department of Biostatistics and Demography, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand; Loei Hospital, Ministry of Public Health, Loei, Thailand

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Pewpan M. Intapan Department of Medicine, and Department of Parasitology, Faculty of Medicine, and Department of Biostatistics and Demography, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand; Loei Hospital, Ministry of Public Health, Loei, Thailand

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Yupa Thavornpitak Department of Medicine, and Department of Parasitology, Faculty of Medicine, and Department of Biostatistics and Demography, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand; Loei Hospital, Ministry of Public Health, Loei, Thailand

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Corticosteroid and the combination of corticosteroid and antihelminthic drug are safe and beneficial in relieving headaches in patients with eosinophilic meningitis. However, clinical trials comparing the efficacies of these regimens have never been reported. We conducted a prospective, open, randomized, controlled study to compare the efficacy of the combination of prednisolone plus albendazole and prednisolone alone for the treatment of eosinophilic meningitis. Our study had 53 patients in the combined treatment group and 51 patients in the prednisolone alone group. There were no significant differences between the two groups with regard to the number of patients who still had headaches after 14 days (0 versus 1, respectively; P = 0.49) and the median length of time until complete disappearance of headache (3 versus 3 days, respectively; P = 0.32. Prednisolone plus albendazole is no better than prednisolone alone for treatment of patients with eosinophilic meningitis.

Author Notes

  • 1

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    Chotmongkol V, Sawnayawisuth K, Thavornpitak Y, 2000. Corticosteroid treatment of eosinophilic meningitis. Clin Infect Dis 31 :660–662.

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    Chotmongkol V, Wongjitrat C, Sawadpanit K, Sawnayawisuth K, 2004. Treatment of eosinophilic meningitis with a combination of albendazole and corticosteroid. Southeast Asian J Trop Med Public Health 35 :172–174.

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    Jitpimolmard S, Sawnayawisuth K, Morakote N, Vejjajiva A, Puntumetakul M, Sanchaisuriya K, Tassaneeyakul W, Tassaneeyakul W, Korwanich N, 2007. Albendazole therapy for eosinophilic meningitis caused by Angiostrongylus cantonensis. Parasitol Res 100 :1293–1296.

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