ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
World Bank W, 1993. Investing in Health. World Development Report. New York: Oxford University Press.
-
2
World Health Organization, 2002. Control of Chagas Disease: Second Report of the WHO Expert Committee. Geneva: UNDP/ World Bank/WHO.
-
3
Rassi A Jr, Rassi A, Little WC, 2000. Chagas’ heart disease. Clin Cardiol 23 :883–889.
-
4
Guzman-Bracho C, 2001. Epidemiology of Chagas disease in Mexico: an update. Trends Parasitol 17 :372–376.
-
5
Cruz-Reyes A, Pickering-Lopez JM, 2006. Chagas disease in Mexico: an analysis of geographical distribution during the past 76 years—a review. Mem Inst Oswaldo Cruz 101 :345–354.
-
6
Estrada-Franco JG, Bhatia V, Diaz-Albiter H, Ochoa-Garcia L, Barbabosa A, Vazquez-Chagoyan J, Martinez-Perez MA, Guzman-Bracho C, Garg N, 2006. Human Trypanosoma cruzi infection and seropositivity in dogs, Mexico. Emerg Infect Dis 12 :624–630.
-
7
Mott KE, Mota EA, Sherlock I, Hoff R, Muniz TM, Oliveira TS, Draper CC, 1978. Trypanosoma cruzi infection in dogs and cats and household seroreactivity to T. cruzi in a rural community in northeast Brazil. Am J Trop Med Hyg 27 :1123–1127.
-
8
Gurtler RE, Cohen JE, Cecere MC, Lauricella MA, Chuit R, Segura EL, 1998. Influence of humans and domestic animals on the household prevalence of Trypanosoma cruzi in Triatoma infestans populations in northwest Argentina. Am J Trop Med Hyg 58 :748–758.
-
9
Laranja FS, Andrade ZA, 1980. Chronic cardiac form of chagas disease in dogs. Arq Bras Cardiol 35 :377–380.
-
10
Andrade ZA, Andrade SG, 1980. Pathology of experimental Chagas disease in dogs. Mem Inst Oswaldo Cruz 75 :77–95.
-
11
Andrade ZA, Andrade SG, Sadigursky M, Maguire JH, 1981. Experimental Chagas’ disease in dogs. A pathologic and ECG study of the chronic indeterminate phase of the infection. Arch Pathol Lab Med 105 :460–464.
-
12
Andrade ZA, 1991. Pathogenesis of Chagas disease. Res Immunol 142 :126–129.
-
13
de Lana M, Chiari E, Tafuri WL, 1992. Experimental Chagas’ disease in dogs. Mem Inst Oswaldo Cruz 87 :59–71.
-
14
Andrade ZA, Andrade SG, Sadigursky M, Wenthold RJ Jr, Hilbert SL, Ferrans VJ, 1997. The indeterminate phase of Chagas’ disease: ultrastructural characterization of cardiac changes in the canine model. Am J Trop Med Hyg 57 :328–336.
-
15
Machado EM, Fernandes AJ, Murta SM, Vitor RW, Camilo DJ Jr, Pinheiro SW, Lopes ER, Adad SJ, Romanha AJ, Pinto Dias JC, 2001. A study of experimental reinfection by Trypanosoma cruzi in dogs. Am J Trop Med Hyg 65 :958–965.
-
16
Lent H, Wygodzisnky P, 1979. Revision of the Triatominae (Hemiptera, Reduviidae) and their significance as vectors of Chagas’ disease. Bull Am Mus Nat Hist 163 :284–286.
-
17
Ferreira AW, Camargo ME, Nakahara OS, 1975. Trypanosoma cruzi: immunoperoxidase antibody test for serologic diagnosis. Exp Parasitol 37 :131–137.
-
18
Bhatia V, Sinha M, Luxon B, Garg N, 2004. Utility of Trypanosoma cruzi sequence database for the identification of potential vaccine candidates: In silico and in vitro screening. Infect Immun 72 :6245–6254.
-
19
Postan M, Dvorak JA, McDaniel JP, 1983. Studies of Trypanosoma cruzi clones in inbred mice. I. A comparison of the course of infection of C3H/HEN- mice with two clones isolated from a common source. Am J Trop Med Hyg 32 :497–506.
-
20
Postan M, McDaniel JP, Dvorak JA, 1987. Comparative studies of the infection of Lewis rats with four Trypanosoma cruzi clones. Trans R Soc Trop Med Hyg 81 :415–419.
-
21
Postan M, McDaniel JP, Dvorak JA, 1984. Studies of Trypanosoma cruzi clones in inbred mice. II. Course of infection of C57BL/6 mice with single-cell-isolated stocks. Am J Trop Med Hyg 33 :236–238.
-
22
Rassi A Jr, Rassi SG, Rassi A, 2001. Sudden death in Chagas’ disease. Arq Bras Cardiol 76 :75–96.
-
23
Tilley LP, 1992. Essentials of Canine and Feline Electrocardiography: Interpretation and Treatment. Baltimore: Lippincott Williams & Wilkins.
-
24
Sisson D, O’Grady MR, Calvert CA, 1999. Myocardial diseases of dogs. Fox PR, Sisson D, Moïse NS, eds. Textbook of Canine and Feline Cardiology: Principles and Clinical Practice. Philadelphia, WB Saunders, 955.
-
25
Machado EM, Camilo Junior DJ, Pinheiro SW, Lopes ER, Fernandes AJ, Dias JC, Adad SJ, 2001. Morphometry of submucous and myenteric esophagic plexus of dogs experimentally reinfected with Trypanosoma cruzi. Mem Inst Oswaldo Cruz 96 :545–548.
-
26
Andrade ZA, Andrade SG, Sadigursky M, 1987. Enhancement of chronic Trypanosoma cruzi myocarditis in dogs treated with low doses of cyclophosphamide. Am J Pathol 127 :467–473.
-
27
Caliari MV, de Lana M, Caja RA, Carneiro CM, Bahia MT, Santos CA, Magalhaes GA, Sampaio IB, Tafuri WL, 2002. Immunohistochemical studies in acute and chronic canine chagasic cardiomyopathy. Virchows Arch 441 :69–76.
-
28
Caliari MV, do Pilar Machado R, de Lana M, Caja RA, Carneiro CM, Bahia MT, dos Santos CA, Magalhaes GA, Sampaio IB, Tafuri WL, 2002. Quantitative analysis of cardiac lesions in chronic canine chagasic cardiomyopathy. Rev Inst Med Trop Sao Paulo 44 :273–278.
-
29
Andrade ZA, 1999. Immunopathology of Chagas disease. Mem Inst Oswaldo Cruz 94 (Suppl 1):71–80.
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Trypanosoma cruzi Circulating in the Southern Region of the State of Mexico (Zumpahuacan) Are Pathogenic: A Dog Model
Alberto Barbabosa-Pliego
Alberto Barbabosa-Pliego
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Hector M. Díaz-Albiter
Hector M. Díaz-Albiter
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Laucel Ochoa-García
Laucel Ochoa-García
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Esteban Aparicio-Burgos
Esteban Aparicio-Burgos
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Sandra M. López-Heydeck
Sandra M. López-Heydeck
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Valente Velásquez-Ordoñez
Valente Velásquez-Ordoñez
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Raul C. Fajardo-Muñoz
Raul C. Fajardo-Muñoz
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Sandra Díaz-González
Sandra Díaz-González
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Roberto Montes De Oca-Jimenez
Roberto Montes De Oca-Jimenez
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Marco Barbosa-Mireles
Marco Barbosa-Mireles
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Carmen Guzmán-Bracho
Carmen Guzmán-Bracho
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Jose G. Estrada-Franco
Jose G. Estrada-Franco
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Nisha Jain Garg
Nisha Jain Garg
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Juan C. Vázquez-Chagoyán
Juan C. Vázquez-Chagoyán
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Here we describe clinical and pathologic evidence of Chagas disease caused in dogs by circulating Trypanosoma cruzi from a newly recognized endemic area in Mexico. We show that the Zumpahuacan isolate, although less virulent than the Sylvio-X10 reference strain that caused acute myocarditis and death, was pathogenic in dogs. Dogs infected with the Zumpahuacan isolate exhibited electrocardiographic alterations, left- and right-ventricle dilation, and hydropericardium. Histologically, diffused perimysial and endomysial lymphoplasmacytic cell infiltration, cardiomyocyte necrosis, and amastigote nests were noted in Zumpahuacan-infected dogs. These findings suggest that the risk of T. cruzi infection and Chagas disease is present in the State of Mexico, and further research is needed to identify the T. cruzi bio-types circulating in southern State of Mexico.
Author Notes
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RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
World Bank W, 1993. Investing in Health. World Development Report. New York: Oxford University Press.
-
2
World Health Organization, 2002. Control of Chagas Disease: Second Report of the WHO Expert Committee. Geneva: UNDP/ World Bank/WHO.
-
3
Rassi A Jr, Rassi A, Little WC, 2000. Chagas’ heart disease. Clin Cardiol 23 :883–889.
-
4
Guzman-Bracho C, 2001. Epidemiology of Chagas disease in Mexico: an update. Trends Parasitol 17 :372–376.
-
5
Cruz-Reyes A, Pickering-Lopez JM, 2006. Chagas disease in Mexico: an analysis of geographical distribution during the past 76 years—a review. Mem Inst Oswaldo Cruz 101 :345–354.
-
6
Estrada-Franco JG, Bhatia V, Diaz-Albiter H, Ochoa-Garcia L, Barbabosa A, Vazquez-Chagoyan J, Martinez-Perez MA, Guzman-Bracho C, Garg N, 2006. Human Trypanosoma cruzi infection and seropositivity in dogs, Mexico. Emerg Infect Dis 12 :624–630.
-
7
Mott KE, Mota EA, Sherlock I, Hoff R, Muniz TM, Oliveira TS, Draper CC, 1978. Trypanosoma cruzi infection in dogs and cats and household seroreactivity to T. cruzi in a rural community in northeast Brazil. Am J Trop Med Hyg 27 :1123–1127.
-
8
Gurtler RE, Cohen JE, Cecere MC, Lauricella MA, Chuit R, Segura EL, 1998. Influence of humans and domestic animals on the household prevalence of Trypanosoma cruzi in Triatoma infestans populations in northwest Argentina. Am J Trop Med Hyg 58 :748–758.
-
9
Laranja FS, Andrade ZA, 1980. Chronic cardiac form of chagas disease in dogs. Arq Bras Cardiol 35 :377–380.
-
10
Andrade ZA, Andrade SG, 1980. Pathology of experimental Chagas disease in dogs. Mem Inst Oswaldo Cruz 75 :77–95.
-
11
Andrade ZA, Andrade SG, Sadigursky M, Maguire JH, 1981. Experimental Chagas’ disease in dogs. A pathologic and ECG study of the chronic indeterminate phase of the infection. Arch Pathol Lab Med 105 :460–464.
-
12
Andrade ZA, 1991. Pathogenesis of Chagas disease. Res Immunol 142 :126–129.
-
13
de Lana M, Chiari E, Tafuri WL, 1992. Experimental Chagas’ disease in dogs. Mem Inst Oswaldo Cruz 87 :59–71.
-
14
Andrade ZA, Andrade SG, Sadigursky M, Wenthold RJ Jr, Hilbert SL, Ferrans VJ, 1997. The indeterminate phase of Chagas’ disease: ultrastructural characterization of cardiac changes in the canine model. Am J Trop Med Hyg 57 :328–336.
-
15
Machado EM, Fernandes AJ, Murta SM, Vitor RW, Camilo DJ Jr, Pinheiro SW, Lopes ER, Adad SJ, Romanha AJ, Pinto Dias JC, 2001. A study of experimental reinfection by Trypanosoma cruzi in dogs. Am J Trop Med Hyg 65 :958–965.
-
16
Lent H, Wygodzisnky P, 1979. Revision of the Triatominae (Hemiptera, Reduviidae) and their significance as vectors of Chagas’ disease. Bull Am Mus Nat Hist 163 :284–286.
-
17
Ferreira AW, Camargo ME, Nakahara OS, 1975. Trypanosoma cruzi: immunoperoxidase antibody test for serologic diagnosis. Exp Parasitol 37 :131–137.
-
18
Bhatia V, Sinha M, Luxon B, Garg N, 2004. Utility of Trypanosoma cruzi sequence database for the identification of potential vaccine candidates: In silico and in vitro screening. Infect Immun 72 :6245–6254.
-
19
Postan M, Dvorak JA, McDaniel JP, 1983. Studies of Trypanosoma cruzi clones in inbred mice. I. A comparison of the course of infection of C3H/HEN- mice with two clones isolated from a common source. Am J Trop Med Hyg 32 :497–506.
-
20
Postan M, McDaniel JP, Dvorak JA, 1987. Comparative studies of the infection of Lewis rats with four Trypanosoma cruzi clones. Trans R Soc Trop Med Hyg 81 :415–419.
-
21
Postan M, McDaniel JP, Dvorak JA, 1984. Studies of Trypanosoma cruzi clones in inbred mice. II. Course of infection of C57BL/6 mice with single-cell-isolated stocks. Am J Trop Med Hyg 33 :236–238.
-
22
Rassi A Jr, Rassi SG, Rassi A, 2001. Sudden death in Chagas’ disease. Arq Bras Cardiol 76 :75–96.
-
23
Tilley LP, 1992. Essentials of Canine and Feline Electrocardiography: Interpretation and Treatment. Baltimore: Lippincott Williams & Wilkins.
-
24
Sisson D, O’Grady MR, Calvert CA, 1999. Myocardial diseases of dogs. Fox PR, Sisson D, Moïse NS, eds. Textbook of Canine and Feline Cardiology: Principles and Clinical Practice. Philadelphia, WB Saunders, 955.
-
25
Machado EM, Camilo Junior DJ, Pinheiro SW, Lopes ER, Fernandes AJ, Dias JC, Adad SJ, 2001. Morphometry of submucous and myenteric esophagic plexus of dogs experimentally reinfected with Trypanosoma cruzi. Mem Inst Oswaldo Cruz 96 :545–548.
-
26
Andrade ZA, Andrade SG, Sadigursky M, 1987. Enhancement of chronic Trypanosoma cruzi myocarditis in dogs treated with low doses of cyclophosphamide. Am J Pathol 127 :467–473.
-
27
Caliari MV, de Lana M, Caja RA, Carneiro CM, Bahia MT, Santos CA, Magalhaes GA, Sampaio IB, Tafuri WL, 2002. Immunohistochemical studies in acute and chronic canine chagasic cardiomyopathy. Virchows Arch 441 :69–76.
-
28
Caliari MV, do Pilar Machado R, de Lana M, Caja RA, Carneiro CM, Bahia MT, dos Santos CA, Magalhaes GA, Sampaio IB, Tafuri WL, 2002. Quantitative analysis of cardiac lesions in chronic canine chagasic cardiomyopathy. Rev Inst Med Trop Sao Paulo 44 :273–278.
-
29
Andrade ZA, 1999. Immunopathology of Chagas disease. Mem Inst Oswaldo Cruz 94 (Suppl 1):71–80.
| Past two years | Past Year | Past 30 Days | |
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