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Trypanosoma cruzi Circulating in the Southern Region of the State of Mexico (Zumpahuacan) Are Pathogenic: A Dog Model

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  • 1 Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México; Laboratorio Estatal de Salud Pública, Estado de México, Toluca, México; Departamento de Parasitología, Instituto Nacional de Diagnóstico y Referencia Epidemiológica INDRE, SSA, México City, Mexico; Departments of Microbiology and Immunology and Pathology, University of Texas Medical Branch, Galveston, Texas
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Here we describe clinical and pathologic evidence of Chagas disease caused in dogs by circulating Trypanosoma cruzi from a newly recognized endemic area in Mexico. We show that the Zumpahuacan isolate, although less virulent than the Sylvio-X10 reference strain that caused acute myocarditis and death, was pathogenic in dogs. Dogs infected with the Zumpahuacan isolate exhibited electrocardiographic alterations, left- and right-ventricle dilation, and hydropericardium. Histologically, diffused perimysial and endomysial lymphoplasmacytic cell infiltration, cardiomyocyte necrosis, and amastigote nests were noted in Zumpahuacan-infected dogs. These findings suggest that the risk of T. cruzi infection and Chagas disease is present in the State of Mexico, and further research is needed to identify the T. cruzi bio-types circulating in southern State of Mexico.

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