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Seroprevalence of Human Granulocytotropic Anaplasmosis in Central and Southeastern China

Shouyin ZhangState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Rong HaiState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Wenyuan LiState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Guohua LiState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Guangyu LinState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Jinrong HeState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Xiuping FuState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Jingshan ZhangState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Hong CaiState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Fengqin MaState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Jianhua ZhangState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Dongzheng YuState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Xue-jie YuState Key Lab for Infectious Diseases Prevention and Control, National Institute for Communicable Diseases Prevention and Control, Chinese Centers for Disease Control and Prevention, Beijing, China; Shanxi Provincial Centers for Disease Control and Prevention, Taiyuan, China; Nanping City Centers for Disease Control and Prevention of Fujian Province, Nanping, China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas

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Human granulocytic anaplasmosis (HGA) is an emerging tick-borne infectious disease. To determine the prevalence of HGA in central and southeastern China, a total of 323 human sera were collected from individuals at high risk for exposure to ticks and animals. The IgG antibody against the etiologic agent of HGA, Anaplasma phagocytophilum was detected with indirect immunofluorescence assay. The results showed that 20% of the tested individuals (64/323) were positive to A. phagocytophilum and that the incidence was higher in male (22%) than female (16%). We concluded that A. phagocytophilum infection was prevalent in central and southeastern China.

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