ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1
Beaver PC, Rosen L, 1945. Memorandum on the first report of Angiostrongylus in man by Nomura and Lin. Am J Trop Med Hyg 13 :589–590.
-
2
Rosen L, Chappell R, Laqueur GL, 1962. Eosinophilic meningo-encephalitis caused by a metastrongylid lung worm of rats. JAMA 179 :620–624.
-
3
Punyagupta S, Juttijudata P, Bunnag T, 1975. Eosinophilic meningitis in Thailand: clinical studies of 484 typical cases probably caused by Angiostrongylus. Am J Trop Med Hyg 24 :921–931.
-
4
Yii CY, 1976. Clinical observations on eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis on Taiwan. Am J Trop Med Hyg 25 :233–249.
-
5
Tsai HC, Liu YC, Kunin CM, Lee SS, Chen YS, Lin HH, Tsai TH, Lin WR, Huang CK, Yen MY, Yen CM, 2001. Eosinophilic-meningitis caused by Angiostrongylus cantonensis: report of 17 cases. Am J Med 111 :109–114.
-
6
Tsai HC, Liu YC, Kunin CM, Lai PH, Lee SS, Chen YS, Wann SR, Lin WR, Huang CK, Ger LP, Lin HH, Yen MY, 2003. Eosinophilic meningitis caused by Angiostrongylus cantonensis associated with eating raw snails: correlation of brain magnetic resonance imaging scans with clinical findings. Am J Trop Med Hyg 68 :281–285.
-
7
Lee JD, Tsai LY, Chen CH, Wang JJ, Hsiao JK, Yen CM, 2006. Blood-brain barrier dysfunction occurring in mice infected with Angiostrongylus cantonensis. Acta Trop 97 :204–211.
-
8
Tsai HC, Liu YC, Susan Lee SJ, Chen ER, Yen CM, 2007. Vascular endothelial growth factor is associated with blood brain barrier dysfunction in eosinophilic meningitis caused by Angiostrongy-lus cantoenesis infection. Am J Trop Med Hyg 76 :592–595.
-
9
Tsai HC, Chung LY, Chen ER, Liu YC, Lee SS, Chen YS, Sy CL, Wann SR, Yen CM, 2008. Association of matrix metalloprotei-nase-9 and tissue inhibitors of metalloproteinase-4 in cerebro-spinal fluid with blood-brain barrier dysfunction in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. Am J Trop Med Hyg 78 :20–27.
-
10
Morishita R, Aoki M, Hashiya N, Yamasaki K, Kurinami H, Shimizu S, Makino H, Takesya Y, Azuma J, Ogihara T, 2004. Therapeutic angiogenesis using hepatocyte growth factor (HGF). Curr Gene Ther 4 :199–206.
-
11
Gohda E, Tsubouchi H, Nakayama H, Hirono S, Takahashi K, Koura M, Hashimoto S, Daikuhara Y, 1986. Human hepatocyte growth factor in plasma from patients with fulminant hepatic failure. Exp Cell Res 166 :139–150.
-
12
Nakamura T, Nawa K, Ichihara A, Kaise N, Nishino T, 1987. Purification and subunit structure of hepatocyte growth factor from rat platelets. FEBS Lett 224 :311–316.
-
13
Birchmeier C, Gherardi E, 1998. Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase. Trends Cell Biol 8 :404–410.
-
14
Paumelle R, Tulasne D, Kherrouche Z, Plaza S, Leroy C, Reveneau S, Vandenbunder B, Fafeur V, 2002. Hepatocyte growth factor/ scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway. Oncogene 21 :2309–2319.
-
15
Date I, Takagi N, Takagi K, Kago T, Matsumoto K, Nakamura T, 2004. Hepatocyte growth factor attenuates cerebral ischemia-induced learning dysfunction. Biochem Biophys Res Commun 319 :1152–1158.
-
16
Date I, Takagi N, Takagi K, Kago T, Matsumoto K, Nakamura T, Takeo S, 2004. Hepatocyte growth factor improved learning and memory dysfunction of microsphereembolized rats. J Neurosci Res 78 :442–453.
-
17
Isogawa K, Akiyoshi J, Kodama K, Matsushita H, Tsutsumi T, Funakoshi H, Nakamura T, 2005. Anxiolytic effect of hepatocyte growth factor infused into rat brain. Neuropsychobiology 51 :34–38.
-
18
Bhargava M, Joseph A, Knesel J, Halaban R, Li Y, Pang S, Goldberg I, Setter E, Donovan MA, Zarnegar R, Michalopoulos GA, Nakamura T, Faletto D, Rosen EM, 1992. Scatter factor and hepatocyte growthfactor—activities, properties, and mechanism. Cell Growth Differ 3 :11–20.
-
19
Honda S, Kagoshima M, Wanaka A, Tohyama M, Matsumoto K, Nakamura T, 1995. Localization and functional coupling of HGF and c-Met/HGF receptor in rat brain: implication as neurotrophic factor. Brain Res Mol Brain Res 32 :197–210.
-
20
Kern MA, Bamborschke S, Nekic M, Schubert D, Rydin C, Lindholm D, Schirmacher P, 2001. Concentrations of hepatocyte growth factor in cerebrospinal fluid under normal and different pathological conditions. Cytokine 14 :170–176.
-
21
Nayeri F, Nilsson I, Hagberg L, Brudin L, Roberg M, Söderström C, Forsberg P, 2000. Hepatocyte growth factor levels in cerebrospinal fluid: a comparison between acute bacterial and nonbacterial meningitis. J Infect Dis 181 :2092–2094.
-
22
Ozden M, Kalkan A, Demirdag K, Denk A, Kilic SS, 2004. Hepatocyte growth factor (HGF) in patients with hepatitis B and meningitis. J Infect 49 :229–235.
-
23
Tsai HC, Lee SS, Huang CK, Yen CM, Chen ER, Liu YC, 2004. Outbreak of eosinophilic meningitis associated with drinking raw vegetable juice in southern Taiwan. Am J Trop Med Hyg 71 :222–226.
-
24
Chye SM, Chang JH, Yen CM, 2000. Immunodiagnosis of human eosinophilic meningitis using an antigen of Angiostrongylus cantonensis L5 with molecular weight 204KD. Acta Trop 75 :9–17.
-
25
Fenton H, Finch PW, Rubin JS, Rosenberg JM, Taylor WG, Kuo-Leblanc V, Rodriguez-Wolf M, Baird A, Schipper HM, Stopa EG, 1998. Hepatocyte growth factor (HGF/SF) in Alzheimer’s disease. Brain Res 779 :262–270.
-
26
Miyazawa T, Matsumoto K, Ohmichi H, Katoh H, Yamashima T, Nakamura T, 1998. Protection of hippocampal neurons from ischemia-induced delayed neuronal death by hepatocyte growth factor: a novel neurotrophic factor. J Cereb Blood Flow Metab 18 :345–348.
-
27
Dorta-Contreras AJ, Reiber H, 1998. Intrathecal synthesis of immunoglobulins in eosinophilic meningoencephalitis due to Angiostrongylus cantonensis. Clin Diagn Lab Immunol 5 :452–455.
-
28
Chang EE, Yen CM, 2004. Eosinophil chemoattracted by eotaxin from cerebrospinal fluid of mice infected with Angiostrongylus cantonensis assayed in a microchamber. Kaohsiung J Med Sci 20 :209–215.
-
29
Sugaya H, Abe T, Yoshimura K, 2001. Eosinophils in the cerebrospinal fluid of mice infected with Angiostrongylus cantonensis are resistant to apoptosis. Int J Parasitol 31 :1649–1658.
-
30
Sugaya H, Aoki M, Abe T, Ishida K, Yoshimura K, 1997. Cytokine responses in mice infected with Angiostrongylus cantonensis. Parasitol Res 83 :10–15.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 778 | 712 | 46 |
| Full Text Views | 192 | 7 | 0 |
| PDF Downloads | 51 | 10 | 2 |
Dynamic Changes of Hepatocyte Growth Factor in Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection
Hung-Chin Tsai
Hung-Chin Tsai
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan and National Yang-Ming University, Taipei, Taiwan, Republic of China; Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohisung, Taiwan, Republic of China
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Yen-Lin Huang
Yen-Lin Huang
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan and National Yang-Ming University, Taipei, Taiwan, Republic of China; Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohisung, Taiwan, Republic of China
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Yung-Ching Liu
Yung-Ching Liu
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan and National Yang-Ming University, Taipei, Taiwan, Republic of China; Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohisung, Taiwan, Republic of China
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Shue-Ren Wann
Shue-Ren Wann
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan and National Yang-Ming University, Taipei, Taiwan, Republic of China; Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohisung, Taiwan, Republic of China
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Susan Shin-Jung Lee
Susan Shin-Jung Lee
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan and National Yang-Ming University, Taipei, Taiwan, Republic of China; Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohisung, Taiwan, Republic of China
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Eng-Rin Chen
Eng-Rin Chen
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan and National Yang-Ming University, Taipei, Taiwan, Republic of China; Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohisung, Taiwan, Republic of China
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Chuan-Min Yen
Chuan-Min Yen
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan and National Yang-Ming University, Taipei, Taiwan, Republic of China; Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohisung, Taiwan, Republic of China
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Ming-Hong Tai
Ming-Hong Tai
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan and National Yang-Ming University, Taipei, Taiwan, Republic of China; Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohisung, Taiwan, Republic of China
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Min-Hon Shi
Min-Hon Shi
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan and National Yang-Ming University, Taipei, Taiwan, Republic of China; Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohisung, Taiwan, Republic of China
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Yao-Shen Chen
Yao-Shen Chen
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan and National Yang-Ming University, Taipei, Taiwan, Republic of China; Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohisung, Taiwan, Republic of China
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Hepatocyte growth factor (HGF) is a member of the angiogenic growth factor family, which exerts a variety of effects on epithelial, endothelial, and neuronal cells by binding to the c-MET receptor tyrosine kinase. It was reported that HGF attenuates cerebral ischemia-induced increase in permeability of the blood-brain barrier (BBB) and decreases in expression of tight junction proteins in cerebral vessels of rats. Studies on the localization of the c-Met/HGF receptor in the rat brain and the interaction with HGF after brain injuries show that HGF plays an important role as a neurotrophic factor in the brain. To assess the role of HGF in patients with eosinophilic meningitis, a retrospective, cohort study was conducted to measure the dynamic changes of HGF in the cerebrospinal fluid (CSF) and blood of nine patients with eosinophilic meningitis. The mean HGFCSF at presentation, 1 week, 2 weeks, and 3 weeks after admission was 539 pg/mL, 540 pg/mL, 376 pg/mL, and 279 pg/mL, respectively. The mean level of HGFCSF at presentation (539 ± 242 pg/mL) and 1 week after admission (540 ± 213 pg/mL) was significantly higher than in controls (162 ± 207 pg/mL)(P = 0.02 and P = 0.01, respectively). The CSF/blood ratio of HGF at presentation (0.61) was higher when compared with physiologic situations in uninfected individuals (0.51). The levels of HGF in CSF were not correlated with the amount of CSF cells or proteins. All patients recovered without neurologic sequelae. These results indicate that high concentrations of HGF in the CSF occur in eosinophilic meningitis, and may have a role in protecting against endothelial injury and reducing BBB dysfunction.
Author Notes
ProCite
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BibTeX
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-
1
Beaver PC, Rosen L, 1945. Memorandum on the first report of Angiostrongylus in man by Nomura and Lin. Am J Trop Med Hyg 13 :589–590.
-
2
Rosen L, Chappell R, Laqueur GL, 1962. Eosinophilic meningo-encephalitis caused by a metastrongylid lung worm of rats. JAMA 179 :620–624.
-
3
Punyagupta S, Juttijudata P, Bunnag T, 1975. Eosinophilic meningitis in Thailand: clinical studies of 484 typical cases probably caused by Angiostrongylus. Am J Trop Med Hyg 24 :921–931.
-
4
Yii CY, 1976. Clinical observations on eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis on Taiwan. Am J Trop Med Hyg 25 :233–249.
-
5
Tsai HC, Liu YC, Kunin CM, Lee SS, Chen YS, Lin HH, Tsai TH, Lin WR, Huang CK, Yen MY, Yen CM, 2001. Eosinophilic-meningitis caused by Angiostrongylus cantonensis: report of 17 cases. Am J Med 111 :109–114.
-
6
Tsai HC, Liu YC, Kunin CM, Lai PH, Lee SS, Chen YS, Wann SR, Lin WR, Huang CK, Ger LP, Lin HH, Yen MY, 2003. Eosinophilic meningitis caused by Angiostrongylus cantonensis associated with eating raw snails: correlation of brain magnetic resonance imaging scans with clinical findings. Am J Trop Med Hyg 68 :281–285.
-
7
Lee JD, Tsai LY, Chen CH, Wang JJ, Hsiao JK, Yen CM, 2006. Blood-brain barrier dysfunction occurring in mice infected with Angiostrongylus cantonensis. Acta Trop 97 :204–211.
-
8
Tsai HC, Liu YC, Susan Lee SJ, Chen ER, Yen CM, 2007. Vascular endothelial growth factor is associated with blood brain barrier dysfunction in eosinophilic meningitis caused by Angiostrongy-lus cantoenesis infection. Am J Trop Med Hyg 76 :592–595.
-
9
Tsai HC, Chung LY, Chen ER, Liu YC, Lee SS, Chen YS, Sy CL, Wann SR, Yen CM, 2008. Association of matrix metalloprotei-nase-9 and tissue inhibitors of metalloproteinase-4 in cerebro-spinal fluid with blood-brain barrier dysfunction in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. Am J Trop Med Hyg 78 :20–27.
-
10
Morishita R, Aoki M, Hashiya N, Yamasaki K, Kurinami H, Shimizu S, Makino H, Takesya Y, Azuma J, Ogihara T, 2004. Therapeutic angiogenesis using hepatocyte growth factor (HGF). Curr Gene Ther 4 :199–206.
-
11
Gohda E, Tsubouchi H, Nakayama H, Hirono S, Takahashi K, Koura M, Hashimoto S, Daikuhara Y, 1986. Human hepatocyte growth factor in plasma from patients with fulminant hepatic failure. Exp Cell Res 166 :139–150.
-
12
Nakamura T, Nawa K, Ichihara A, Kaise N, Nishino T, 1987. Purification and subunit structure of hepatocyte growth factor from rat platelets. FEBS Lett 224 :311–316.
-
13
Birchmeier C, Gherardi E, 1998. Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase. Trends Cell Biol 8 :404–410.
-
14
Paumelle R, Tulasne D, Kherrouche Z, Plaza S, Leroy C, Reveneau S, Vandenbunder B, Fafeur V, 2002. Hepatocyte growth factor/ scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway. Oncogene 21 :2309–2319.
-
15
Date I, Takagi N, Takagi K, Kago T, Matsumoto K, Nakamura T, 2004. Hepatocyte growth factor attenuates cerebral ischemia-induced learning dysfunction. Biochem Biophys Res Commun 319 :1152–1158.
-
16
Date I, Takagi N, Takagi K, Kago T, Matsumoto K, Nakamura T, Takeo S, 2004. Hepatocyte growth factor improved learning and memory dysfunction of microsphereembolized rats. J Neurosci Res 78 :442–453.
-
17
Isogawa K, Akiyoshi J, Kodama K, Matsushita H, Tsutsumi T, Funakoshi H, Nakamura T, 2005. Anxiolytic effect of hepatocyte growth factor infused into rat brain. Neuropsychobiology 51 :34–38.
-
18
Bhargava M, Joseph A, Knesel J, Halaban R, Li Y, Pang S, Goldberg I, Setter E, Donovan MA, Zarnegar R, Michalopoulos GA, Nakamura T, Faletto D, Rosen EM, 1992. Scatter factor and hepatocyte growthfactor—activities, properties, and mechanism. Cell Growth Differ 3 :11–20.
-
19
Honda S, Kagoshima M, Wanaka A, Tohyama M, Matsumoto K, Nakamura T, 1995. Localization and functional coupling of HGF and c-Met/HGF receptor in rat brain: implication as neurotrophic factor. Brain Res Mol Brain Res 32 :197–210.
-
20
Kern MA, Bamborschke S, Nekic M, Schubert D, Rydin C, Lindholm D, Schirmacher P, 2001. Concentrations of hepatocyte growth factor in cerebrospinal fluid under normal and different pathological conditions. Cytokine 14 :170–176.
-
21
Nayeri F, Nilsson I, Hagberg L, Brudin L, Roberg M, Söderström C, Forsberg P, 2000. Hepatocyte growth factor levels in cerebrospinal fluid: a comparison between acute bacterial and nonbacterial meningitis. J Infect Dis 181 :2092–2094.
-
22
Ozden M, Kalkan A, Demirdag K, Denk A, Kilic SS, 2004. Hepatocyte growth factor (HGF) in patients with hepatitis B and meningitis. J Infect 49 :229–235.
-
23
Tsai HC, Lee SS, Huang CK, Yen CM, Chen ER, Liu YC, 2004. Outbreak of eosinophilic meningitis associated with drinking raw vegetable juice in southern Taiwan. Am J Trop Med Hyg 71 :222–226.
-
24
Chye SM, Chang JH, Yen CM, 2000. Immunodiagnosis of human eosinophilic meningitis using an antigen of Angiostrongylus cantonensis L5 with molecular weight 204KD. Acta Trop 75 :9–17.
-
25
Fenton H, Finch PW, Rubin JS, Rosenberg JM, Taylor WG, Kuo-Leblanc V, Rodriguez-Wolf M, Baird A, Schipper HM, Stopa EG, 1998. Hepatocyte growth factor (HGF/SF) in Alzheimer’s disease. Brain Res 779 :262–270.
-
26
Miyazawa T, Matsumoto K, Ohmichi H, Katoh H, Yamashima T, Nakamura T, 1998. Protection of hippocampal neurons from ischemia-induced delayed neuronal death by hepatocyte growth factor: a novel neurotrophic factor. J Cereb Blood Flow Metab 18 :345–348.
-
27
Dorta-Contreras AJ, Reiber H, 1998. Intrathecal synthesis of immunoglobulins in eosinophilic meningoencephalitis due to Angiostrongylus cantonensis. Clin Diagn Lab Immunol 5 :452–455.
-
28
Chang EE, Yen CM, 2004. Eosinophil chemoattracted by eotaxin from cerebrospinal fluid of mice infected with Angiostrongylus cantonensis assayed in a microchamber. Kaohsiung J Med Sci 20 :209–215.
-
29
Sugaya H, Abe T, Yoshimura K, 2001. Eosinophils in the cerebrospinal fluid of mice infected with Angiostrongylus cantonensis are resistant to apoptosis. Int J Parasitol 31 :1649–1658.
-
30
Sugaya H, Aoki M, Abe T, Ishida K, Yoshimura K, 1997. Cytokine responses in mice infected with Angiostrongylus cantonensis. Parasitol Res 83 :10–15.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 778 | 712 | 46 |
| Full Text Views | 192 | 7 | 0 |
| PDF Downloads | 51 | 10 | 2 |