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Reference Manager
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-
1
Guandalini S, 2000. Treatment of acute diarrhea in the new millennium. J Pediatr Gastroenterol Nutr 30 :486–489.
-
2
Bercu TE, Petri WA, Behm JW, 2007. Amebic colitis: new insights into pathogenesis and treatment. Curr Gastroenterol Rep 9 :429–433.
-
3
Guandalini S, 2008. Probiotics for children with diarrhea: an update. J Clin Gastroenterol 42 (Suppl 2):S53–S57.
-
4
Mansour-Ghanaei F, Dehbashi N, Yazdanparast K, Shafaghi A, 2003. Efficacy of Saccharomyces boulardii with antibiotics in acute amoebiasis. World J Gastroenterol 9 :1832–1833.
-
5
Tanyuksel M, Petri WA Jr, 2003. Laboratory diagnosis of amebiasis. Clin Microbiol Rev 16 :713–729.
-
6
Lewis SJ, Heaton KW, 1997. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 32 :920–924.
-
7
Htwe K, Yee KS, Tin M, Vandenplas Y, 2008. Effect of Saccharomyces boulardii in the treatment of acute watery diarrhea in Myanmar children: a randomized controlled study. Am J Trop Med Hyg 78 :214–216.
-
8
Villarruel G, Rubio DM, Lopez F, Cintioni J, Gurevech R, Romero G, Vandenplas Y, 2007. Saccharomyces boulardii in acute childhood diarrhoea: a randomized, placebo-controlled study. Acta Paediatr 96 :538–541.
-
9
Szajewska H, Skórka A, Dylag M, 2007. Meta-analysis: Saccharomyces boulardii for treating acute diarrhoea in children. Aliment Pharmacol Ther 25 :257–264.
-
10
Szajewska H, Mrukowicz J, 2005. Meta-analysis: non-pathogenic yeast Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther 22 :365–372.
-
11
Kurugöl Z, Koturoğlu G, 2005. Effects of Saccharomyces boulardii in children with acute diarrhoea. Acta Paediatr 94 :44–47.
-
12
Besirbellioglu BA, Ulcay A, Can M, Erdem H, Tanyuksel M, Avci IY, Araz E, Pahsa A, 2006. Saccharomyces boulardii and infection due to Giardia lamblia. Scand J Infect Dis 38 :479–481.
-
13
Zanello G, Meurens F, Berri M, Salmon H, 2008. Saccharomyces boulardii effects on gastrointestinal diseases. Curr Issues Mol Biol 11 :47–58.
-
14
Czerucka D, Piche T, Rampal P, 2007. Review article: yeast as probiotics–Saccharomyces boulardii. Aliment Pharmacol Ther 26 :767–778.
-
15
Rigothier MC, Maccario J, Gayral P, 1994. Inhibitory activity of Saccharomyces yeasts on the adhesion of Entamoeba histolytica trophozoites to human erythrocytes in vitro. Parasitol Res 80 :10–15.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 380 | 218 | 14 |
| Full Text Views | 525 | 9 | 0 |
| PDF Downloads | 320 | 8 | 0 |
Clinical Efficacy of Saccharomyces boulardii and Metronidazole Compared to Metronidazole Alone in Children with Acute Bloody Diarrhea Caused by Amebiasis: A Prospective, Randomized, Open Label Study
Ener C. Dinleyici
Ener C. Dinleyici
Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Eskisehir, Turkey; Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Gastroenterology and Hepatology, Eskisehir, Turkey; Eskisehir Osmangazi University Faculty of Medicine, Department of Parasitology, Eskisehir, Turkey; Universitair Ziekenhuis Brussel Kinderen, Vrije Universiteit Brussel, Brussels, Belgium
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Makbule Eren
Makbule Eren
Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Eskisehir, Turkey; Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Gastroenterology and Hepatology, Eskisehir, Turkey; Eskisehir Osmangazi University Faculty of Medicine, Department of Parasitology, Eskisehir, Turkey; Universitair Ziekenhuis Brussel Kinderen, Vrije Universiteit Brussel, Brussels, Belgium
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Zeynel A. Yargic
Zeynel A. Yargic
Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Eskisehir, Turkey; Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Gastroenterology and Hepatology, Eskisehir, Turkey; Eskisehir Osmangazi University Faculty of Medicine, Department of Parasitology, Eskisehir, Turkey; Universitair Ziekenhuis Brussel Kinderen, Vrije Universiteit Brussel, Brussels, Belgium
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Nihal Dogan
Nihal Dogan
Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Eskisehir, Turkey; Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Gastroenterology and Hepatology, Eskisehir, Turkey; Eskisehir Osmangazi University Faculty of Medicine, Department of Parasitology, Eskisehir, Turkey; Universitair Ziekenhuis Brussel Kinderen, Vrije Universiteit Brussel, Brussels, Belgium
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Yvan Vandenplas
Yvan Vandenplas
Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Eskisehir, Turkey; Eskisehir Osmangazi University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Gastroenterology and Hepatology, Eskisehir, Turkey; Eskisehir Osmangazi University Faculty of Medicine, Department of Parasitology, Eskisehir, Turkey; Universitair Ziekenhuis Brussel Kinderen, Vrije Universiteit Brussel, Brussels, Belgium
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The aim was to evaluate the efficacy of Saccharomyces boulardii (Sb) in addition to metronidazole in amebiasis. A prospective, randomized, open clinical trial was performed in 50 children presenting with acute bloody diarrhea caused by Entameba histolytica. Group A and B (each N = 25) was treated with metronidazole, but Sb (250 mg, twice daily) during the 7 days was added to Group B patients who were re-evaluated 2, 3, 5, 10, and 30 days after diagnosis. Duration of bloody diarrhea was significantly longer in Group A (72.0 ± 28.5 versus 42.2 ± 17.4 hours, P < 0.001). On day 5, amebic cysts had disappeared in all children in Group B, whereas in Group A, amebic cysts were still present in 6 children (P < 0.05). On day 10, all children were cured and cysts had disappeared in all. The addition of Sb to metronidazole in amebiasis significantly decreases duration of (bloody) diarrhea and enhances clearance of cysts.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1
Guandalini S, 2000. Treatment of acute diarrhea in the new millennium. J Pediatr Gastroenterol Nutr 30 :486–489.
-
2
Bercu TE, Petri WA, Behm JW, 2007. Amebic colitis: new insights into pathogenesis and treatment. Curr Gastroenterol Rep 9 :429–433.
-
3
Guandalini S, 2008. Probiotics for children with diarrhea: an update. J Clin Gastroenterol 42 (Suppl 2):S53–S57.
-
4
Mansour-Ghanaei F, Dehbashi N, Yazdanparast K, Shafaghi A, 2003. Efficacy of Saccharomyces boulardii with antibiotics in acute amoebiasis. World J Gastroenterol 9 :1832–1833.
-
5
Tanyuksel M, Petri WA Jr, 2003. Laboratory diagnosis of amebiasis. Clin Microbiol Rev 16 :713–729.
-
6
Lewis SJ, Heaton KW, 1997. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 32 :920–924.
-
7
Htwe K, Yee KS, Tin M, Vandenplas Y, 2008. Effect of Saccharomyces boulardii in the treatment of acute watery diarrhea in Myanmar children: a randomized controlled study. Am J Trop Med Hyg 78 :214–216.
-
8
Villarruel G, Rubio DM, Lopez F, Cintioni J, Gurevech R, Romero G, Vandenplas Y, 2007. Saccharomyces boulardii in acute childhood diarrhoea: a randomized, placebo-controlled study. Acta Paediatr 96 :538–541.
-
9
Szajewska H, Skórka A, Dylag M, 2007. Meta-analysis: Saccharomyces boulardii for treating acute diarrhoea in children. Aliment Pharmacol Ther 25 :257–264.
-
10
Szajewska H, Mrukowicz J, 2005. Meta-analysis: non-pathogenic yeast Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther 22 :365–372.
-
11
Kurugöl Z, Koturoğlu G, 2005. Effects of Saccharomyces boulardii in children with acute diarrhoea. Acta Paediatr 94 :44–47.
-
12
Besirbellioglu BA, Ulcay A, Can M, Erdem H, Tanyuksel M, Avci IY, Araz E, Pahsa A, 2006. Saccharomyces boulardii and infection due to Giardia lamblia. Scand J Infect Dis 38 :479–481.
-
13
Zanello G, Meurens F, Berri M, Salmon H, 2008. Saccharomyces boulardii effects on gastrointestinal diseases. Curr Issues Mol Biol 11 :47–58.
-
14
Czerucka D, Piche T, Rampal P, 2007. Review article: yeast as probiotics–Saccharomyces boulardii. Aliment Pharmacol Ther 26 :767–778.
-
15
Rigothier MC, Maccario J, Gayral P, 1994. Inhibitory activity of Saccharomyces yeasts on the adhesion of Entamoeba histolytica trophozoites to human erythrocytes in vitro. Parasitol Res 80 :10–15.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 380 | 218 | 14 |
| Full Text Views | 525 | 9 | 0 |
| PDF Downloads | 320 | 8 | 0 |