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Protein Kinase A Regulatory Subunit Interacts with P-Type ATPases in Trypanosoma cruzi

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  • 1 Department of Pathology and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York; Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo, Japan

Cyclic AMP–protein kinase A (PKA) signaling is important for the growth and differentiation of Trypanosoma cruzi. Immunofluorescence suggests that PKA can associate with the plasma membrane of trypomastigotes. We found that the PKA regulatory subunit interacts with several P-type ATPases. These P-type ATPases may play a role in anchoring PKA to the plasma membrane in T. cruzi.

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