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-
1
Ammann RW, Eckert J, 1996. Cestodes. Echinococcus. Gastroenterol Clin North Am 25 :655–689.
-
2
Reuter S, Buck A, Grebe O, Nussle-Kugele K, Kern P, Manfras BJ, 2003. Salvage treatment with amphotericin B in progressive human alveolar echinococcosis. Antimicrob Agents Chemother 47 :3586–3591.
-
3
Eckert J, Jacquier P, Baumann D, Raeber PA, 1995. Human echinococcosis in Switzerland, 1984–1992 [in German]. Schweiz Med Wochenschr 125 :1989–1998.
-
4
Ehrhardt AR, Reuter S, Buck AK, Haenle MM, Mason RA, Gabelmann A, Kern P, Kratzer W, 2007. Assessment of disease activity in alveolar echinococcosis: a comparison of contrast-enhanced ultrasound, three-phase helical CT and [(18)F]fluorodeoxyglucose positron-emission tomography. Abdom Imaging 32 :730–736.
-
5
Reuter S, Schirrmeister H, Kratzer W, Dreweck C, Reske SN, Kern P, 1999. Pericystic metabolic activity in alveolar echinococcosis: assessment and follow-up by positron emission tomography. Clin Infect Dis 29 :1157–1163.
-
6
Stumpe KD, Renner-Schneiter EC, Kuenzle AK, Grimm F, Kadry Z, Clavien PA, Deplazes P, von Schulthess GK, Muellhaupt B, Ammann RW, Renner EL, 2007. F-18-fluorodeoxyglucose (FDG) positron-emission tomography of Echinococcus multilocularis liver lesions: prospective evaluation of its value for diagnosis and follow-up during benzimidazole therapy. Infection 35 :11–18.
-
7
Ammann RW, Renner EC, Gottstein B, Grimm F, Eckert J, Renner EL; Swiss Echinococcosis Study Group, 2004. Immunosurveillance of alveolar echinococcosis by specific humoral and cellular immune tests: long-term analysis of the Swiss chemotherapy trial (1976–2001). J Hepatol 41 :551–559.
-
8
Fujimoto Y, Ito A, Ishikawa Y, Inoue M, Suzuki Y, Ohhira M, Ohtake T, Kohgo Y, 2005. Usefulness of recombinant Em18-ELISA to evaluate efficacy of treatment in patients with alveolar echinococcosis. J Gastroenterol 40 :426–431.
-
9
Kern P, Wen H, Sato N, Vuitton DA, Gruener B, Shao Y, Delabrousse E, Kratzer W, Bresson-Hadni S, 2006. WHO classification of alveolar echinococcosis: principles and application. Parasitol Int 55 :S283–S287.
-
10
Frosch PM, Frosch M, Pfister T, Schaad V, Bitter-Suermann D, 1991. Cloning and characterisation of an immunodominant major surface antigen of Echinococcus multilocularis. Mol Biochem Parasitol 48 :121–130.
-
11
Sako Y, Nakao M, Nakaya K, Yamasaki H, Gottstein B, Lightowers MW, Schantz PM, Ito A, 2002. Alveolar echinococcosis: characterization of diagnostic antigen Em18 and serological evaluation of recombinant Em18. J Clin Microbiol 40 :2760–2765.
-
12
Wellinghausen N, Jochle W, Reuter S, Flegel WA, Grunert A, Kern P, 1999. Zinc status in patients with alveolar echinococcosis is related to disease progression. Parasite Immunol 21 :237–241.
-
13
Schantz PM, Wilson JF, Wahlquist SP, Boss LP, Rausch RL, 1983. Serologic tests for diagnosis and post-treatment evaluation of patients with alveolar hydatid disease (Echinococcus multilocularis). Am J Trop Med Hyg 32 :1381–1386.
-
14
Wellinghausen N, Kern P, 2001. A new ImmunoCAP assay for detection of Echinococcus multilocularis-specific IgE. Acta Trop 79 :123–127.
-
15
Dreweck CM, Lüder CG, Soboslay PT, Kern P, 1997. Subclass-specific serological reactivity and IgG4-specific antigen recognition in human echinococcosis. Trop Med Int Health 2 :779–787.
-
16
Ito A, Schantz PM, Wilson JF, 1995. Em18, a new serodiagnostic marker for differentiation of active and inactive cases of alveolar hydatid disease. Am J Trop Med Hyg 52 :41–44.
-
17
Ito A, Wen H, Craig PS, Liang M, Nakao M, Horii T, Pang XL, Okamoto M, Itho M, Osawa Y, Wang XG, Liu YH, 1997. Antibody responses against Em18 and Em16 serodiagnostic markers in alveolar and cystic echinococcosis. Jpn J Med Sci Biol 50 :19–26.
-
18
Wen H, Craig PS, Ito A, Vuitton DA, Bresson-Hadni S, Allan JC, Rogan M, Paollilo E, Shambesh M, 1995. Immunoblot evaluation of IgG and IgG subclass antibody responses for immunodiagnosis of human alveolar echinococcosis. Ann Trop Med Parasitol 89 :485–495.
-
19
Gottstein B, Tschudi K, Eckert J, Ammann R, 1989. Em2-ELISA for the follow-up of alveolar echinococcosis after complete surgical resection of liver lesions. Trans R Soc Trop Med Hyg 83 :389–393.
-
20
Gottstein B, Mesarina B, Tanner I, Ammann RW, Wilson JF, Eckert J, Lanier A, 1991. Specific cellular and humoral immune responses in patients with different long-term courses of alveolar echinococcosis (infection with Echinococcus multilocularis). Am J Trop Med Hyg 45 :734–742.
-
21
Ma L, Ito A, Liu YH, Wang XG, Yao YQ, Yu DG, Chen YT, 1997. Alveolar echinococcosis: Em2 plus-ELISA and Em18-western blots for follow-up after treatment with albendazole. Trans R Soc Trop Med Hyg 91 :476–478.
-
22
Miguet JP, Bresson-Hadni S, 1989. Alveolar echinococcosis of the liver. J Hepatol 8 :373–379.
-
23
Sturm D, Menzel J, Gottstein B, Kern P, 1995. Interleukin-5 is the predominant cytokine produced by peripheral blood mono-nuclear cells in alveolar echinococcosis. Infect Immun 63 :1688–1697.
-
24
Hemphill A, Stettler M, Walker M, Siles-Lucas M, Fink R, Gottstein B, 2003. In vitro culture of Echinococcus multilocularis and Echinococcus vogeli metacestodes: studies on the host-parasite interface. Acta Trop 85 :145–155.
-
25
Rausch RL, Wilson JF, Schantz PM, McMahon BJ, 1987. Spontaneous death of Echinococcus multilocularis: cases diagnosed serologically (by Em2 ELISA) and clinical significance. Am J Trop Med Hyg 36 :576–585.
-
26
Posselt A, 1931. Die pathologische Anatomie der vielkammerigen Blasenwurmgeschwulst (Echinococcus alveolaris) der Leber. Frankf Z Pathol 41 :45–99.
-
27
Lanier AP, Trujillo DE, Schantz PM, Wilson JF, Gottstein B, McMahon BJ, 1987. Comparison of serologic tests for the diagnosis and follow-up of alveolar hydatid disease. Am J Trop Med Hyg 37 :609–615.
-
28
Gottstein B, 1992. Molecular and immunological diagnosis of echinococcosis. Clin Microbiol Rev 5 :248–261.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 26 | 26 | 12 |
| Full Text Views | 290 | 68 | 0 |
| PDF Downloads | 88 | 22 | 0 |
Close Relationship between Clinical Regression and Specific Serology in the Follow-up of Patients with Alveolar Echinococcosis in Different Clinical Stages
Dennis Tappe
Dennis Tappe
Institute of Hygiene and Microbiology, University of Würzburg, Germany; Department of Parasitology, Asahikawa Medical College, Japan; Comprehensive Infectious Diseases Center, Division of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center Ulm, Germany
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Matthias Frosch
Matthias Frosch
Institute of Hygiene and Microbiology, University of Würzburg, Germany; Department of Parasitology, Asahikawa Medical College, Japan; Comprehensive Infectious Diseases Center, Division of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center Ulm, Germany
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Yasuhito Sako
Yasuhito Sako
Institute of Hygiene and Microbiology, University of Würzburg, Germany; Department of Parasitology, Asahikawa Medical College, Japan; Comprehensive Infectious Diseases Center, Division of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center Ulm, Germany
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Sonoyo Itoh
Sonoyo Itoh
Institute of Hygiene and Microbiology, University of Würzburg, Germany; Department of Parasitology, Asahikawa Medical College, Japan; Comprehensive Infectious Diseases Center, Division of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center Ulm, Germany
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Beate Grüner
Beate Grüner
Institute of Hygiene and Microbiology, University of Würzburg, Germany; Department of Parasitology, Asahikawa Medical College, Japan; Comprehensive Infectious Diseases Center, Division of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center Ulm, Germany
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Stefan Reuter
Stefan Reuter
Institute of Hygiene and Microbiology, University of Würzburg, Germany; Department of Parasitology, Asahikawa Medical College, Japan; Comprehensive Infectious Diseases Center, Division of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center Ulm, Germany
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Minoru Nakao
Minoru Nakao
Institute of Hygiene and Microbiology, University of Würzburg, Germany; Department of Parasitology, Asahikawa Medical College, Japan; Comprehensive Infectious Diseases Center, Division of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center Ulm, Germany
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Akira Ito
Akira Ito
Institute of Hygiene and Microbiology, University of Würzburg, Germany; Department of Parasitology, Asahikawa Medical College, Japan; Comprehensive Infectious Diseases Center, Division of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center Ulm, Germany
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Peter Kern
Peter Kern
Institute of Hygiene and Microbiology, University of Würzburg, Germany; Department of Parasitology, Asahikawa Medical College, Japan; Comprehensive Infectious Diseases Center, Division of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center Ulm, Germany
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We compared four enzyme-linked immunosorbent assays (ELISAs) with 172 serum samples from 28 patients with alveolar echinococcosis in different clinical stages according to the World Health Organization–PNM (P = parasitic mass in the liver, N = involvement of neighboring organs, M = metastasis) staging system. The sequential antibody responses against Em 2plus, Em10, and Em18 antigens, and a crude antigen extract were measured in cohorts with resected and unresected lesions. Antibody levels in all assays correlated with the PNM stage before treatment, and the highest correlation was shown for the Em18 assay. The PNM stage did not influence the antibody kinetics, but changes in antibody levels depended on the treatment. In patients after curative surgery, seroreversion in the Em 2plus ELISA indicated successful resection of lesions in more patients than any other assay, irrespective of the clinical stage. There were no significant differences in the time before assays that use recombinant or purified antigens became unreactive. Antibodies directed against crude antigens were detectable longer than other antibodies in all patient cohorts and stages.
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-
1
Ammann RW, Eckert J, 1996. Cestodes. Echinococcus. Gastroenterol Clin North Am 25 :655–689.
-
2
Reuter S, Buck A, Grebe O, Nussle-Kugele K, Kern P, Manfras BJ, 2003. Salvage treatment with amphotericin B in progressive human alveolar echinococcosis. Antimicrob Agents Chemother 47 :3586–3591.
-
3
Eckert J, Jacquier P, Baumann D, Raeber PA, 1995. Human echinococcosis in Switzerland, 1984–1992 [in German]. Schweiz Med Wochenschr 125 :1989–1998.
-
4
Ehrhardt AR, Reuter S, Buck AK, Haenle MM, Mason RA, Gabelmann A, Kern P, Kratzer W, 2007. Assessment of disease activity in alveolar echinococcosis: a comparison of contrast-enhanced ultrasound, three-phase helical CT and [(18)F]fluorodeoxyglucose positron-emission tomography. Abdom Imaging 32 :730–736.
-
5
Reuter S, Schirrmeister H, Kratzer W, Dreweck C, Reske SN, Kern P, 1999. Pericystic metabolic activity in alveolar echinococcosis: assessment and follow-up by positron emission tomography. Clin Infect Dis 29 :1157–1163.
-
6
Stumpe KD, Renner-Schneiter EC, Kuenzle AK, Grimm F, Kadry Z, Clavien PA, Deplazes P, von Schulthess GK, Muellhaupt B, Ammann RW, Renner EL, 2007. F-18-fluorodeoxyglucose (FDG) positron-emission tomography of Echinococcus multilocularis liver lesions: prospective evaluation of its value for diagnosis and follow-up during benzimidazole therapy. Infection 35 :11–18.
-
7
Ammann RW, Renner EC, Gottstein B, Grimm F, Eckert J, Renner EL; Swiss Echinococcosis Study Group, 2004. Immunosurveillance of alveolar echinococcosis by specific humoral and cellular immune tests: long-term analysis of the Swiss chemotherapy trial (1976–2001). J Hepatol 41 :551–559.
-
8
Fujimoto Y, Ito A, Ishikawa Y, Inoue M, Suzuki Y, Ohhira M, Ohtake T, Kohgo Y, 2005. Usefulness of recombinant Em18-ELISA to evaluate efficacy of treatment in patients with alveolar echinococcosis. J Gastroenterol 40 :426–431.
-
9
Kern P, Wen H, Sato N, Vuitton DA, Gruener B, Shao Y, Delabrousse E, Kratzer W, Bresson-Hadni S, 2006. WHO classification of alveolar echinococcosis: principles and application. Parasitol Int 55 :S283–S287.
-
10
Frosch PM, Frosch M, Pfister T, Schaad V, Bitter-Suermann D, 1991. Cloning and characterisation of an immunodominant major surface antigen of Echinococcus multilocularis. Mol Biochem Parasitol 48 :121–130.
-
11
Sako Y, Nakao M, Nakaya K, Yamasaki H, Gottstein B, Lightowers MW, Schantz PM, Ito A, 2002. Alveolar echinococcosis: characterization of diagnostic antigen Em18 and serological evaluation of recombinant Em18. J Clin Microbiol 40 :2760–2765.
-
12
Wellinghausen N, Jochle W, Reuter S, Flegel WA, Grunert A, Kern P, 1999. Zinc status in patients with alveolar echinococcosis is related to disease progression. Parasite Immunol 21 :237–241.
-
13
Schantz PM, Wilson JF, Wahlquist SP, Boss LP, Rausch RL, 1983. Serologic tests for diagnosis and post-treatment evaluation of patients with alveolar hydatid disease (Echinococcus multilocularis). Am J Trop Med Hyg 32 :1381–1386.
-
14
Wellinghausen N, Kern P, 2001. A new ImmunoCAP assay for detection of Echinococcus multilocularis-specific IgE. Acta Trop 79 :123–127.
-
15
Dreweck CM, Lüder CG, Soboslay PT, Kern P, 1997. Subclass-specific serological reactivity and IgG4-specific antigen recognition in human echinococcosis. Trop Med Int Health 2 :779–787.
-
16
Ito A, Schantz PM, Wilson JF, 1995. Em18, a new serodiagnostic marker for differentiation of active and inactive cases of alveolar hydatid disease. Am J Trop Med Hyg 52 :41–44.
-
17
Ito A, Wen H, Craig PS, Liang M, Nakao M, Horii T, Pang XL, Okamoto M, Itho M, Osawa Y, Wang XG, Liu YH, 1997. Antibody responses against Em18 and Em16 serodiagnostic markers in alveolar and cystic echinococcosis. Jpn J Med Sci Biol 50 :19–26.
-
18
Wen H, Craig PS, Ito A, Vuitton DA, Bresson-Hadni S, Allan JC, Rogan M, Paollilo E, Shambesh M, 1995. Immunoblot evaluation of IgG and IgG subclass antibody responses for immunodiagnosis of human alveolar echinococcosis. Ann Trop Med Parasitol 89 :485–495.
-
19
Gottstein B, Tschudi K, Eckert J, Ammann R, 1989. Em2-ELISA for the follow-up of alveolar echinococcosis after complete surgical resection of liver lesions. Trans R Soc Trop Med Hyg 83 :389–393.
-
20
Gottstein B, Mesarina B, Tanner I, Ammann RW, Wilson JF, Eckert J, Lanier A, 1991. Specific cellular and humoral immune responses in patients with different long-term courses of alveolar echinococcosis (infection with Echinococcus multilocularis). Am J Trop Med Hyg 45 :734–742.
-
21
Ma L, Ito A, Liu YH, Wang XG, Yao YQ, Yu DG, Chen YT, 1997. Alveolar echinococcosis: Em2 plus-ELISA and Em18-western blots for follow-up after treatment with albendazole. Trans R Soc Trop Med Hyg 91 :476–478.
-
22
Miguet JP, Bresson-Hadni S, 1989. Alveolar echinococcosis of the liver. J Hepatol 8 :373–379.
-
23
Sturm D, Menzel J, Gottstein B, Kern P, 1995. Interleukin-5 is the predominant cytokine produced by peripheral blood mono-nuclear cells in alveolar echinococcosis. Infect Immun 63 :1688–1697.
-
24
Hemphill A, Stettler M, Walker M, Siles-Lucas M, Fink R, Gottstein B, 2003. In vitro culture of Echinococcus multilocularis and Echinococcus vogeli metacestodes: studies on the host-parasite interface. Acta Trop 85 :145–155.
-
25
Rausch RL, Wilson JF, Schantz PM, McMahon BJ, 1987. Spontaneous death of Echinococcus multilocularis: cases diagnosed serologically (by Em2 ELISA) and clinical significance. Am J Trop Med Hyg 36 :576–585.
-
26
Posselt A, 1931. Die pathologische Anatomie der vielkammerigen Blasenwurmgeschwulst (Echinococcus alveolaris) der Leber. Frankf Z Pathol 41 :45–99.
-
27
Lanier AP, Trujillo DE, Schantz PM, Wilson JF, Gottstein B, McMahon BJ, 1987. Comparison of serologic tests for the diagnosis and follow-up of alveolar hydatid disease. Am J Trop Med Hyg 37 :609–615.
-
28
Gottstein B, 1992. Molecular and immunological diagnosis of echinococcosis. Clin Microbiol Rev 5 :248–261.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 26 | 26 | 12 |
| Full Text Views | 290 | 68 | 0 |
| PDF Downloads | 88 | 22 | 0 |