Author:
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-
1
UNAIDS, 2004. Available at: http://whqlibdea.who.int/unaids/2004/9291733903.pdf. Accessed August 15, 2008.
-
2
WHO, 2007. UNAIDS Fact Sheet-Revised HIV estimates. Availableat:http://data.unaids.org/pub/EPISlides/2007/071118_epi_revisions_factsheet_en.pdf. Accessed August 15, 2008.
-
3
Harries AD, Nyangulu DS, Hargreaves NJ, Kaluwa O, Salaniponi FM, 2001. Preventing antiretroviral anarchy in sub-Saharan Africa. Lancet 358 :410–414.
-
4
Wools-Kaloustian K, Kimaiyo S, Diero L, Siika A, Sidle J, Yiannoutsos CT, Musick B, Einterz R, Fife KH, Tierney WM, 2006. Viability and effectiveness of large-scale HIV treatment initiatives in sub-Saharan Africa: experience from western Kenya. AIDS 20 :41–48.
-
5
Nachega JB, Stein DM, Lehman DA, Hlatshwayo D, Mothopeng R, Chaisson RE, Karstaedt AS, 2004. Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. AIDS Res Hum Retroviruses 20 :1053–1056.
-
6
Marazzi MC, Bartolo M, Emberti Gialloreti L, Germano P, Guidotti G, Liotta G, Magnano San Lio M, Mancinelli S, Modolo MA, Narciso P, Perno CF, Scarcella P, Tintisona G, Palombi L, 2006. Improving adherence to highly active anti-retroviral therapy in Africa: the DREAM programme in Mozambique. Health Educ Res 21 :34–42.
-
7
Weidle PJ, Wamai N, Solberg P, Liechty C, Sendagala S, Were W, Mermin J, Buchacz K, Behumbiize P, Ransom RL, Bunnell R, 2006. Adherence to antiretroviral therapy in a home-based AIDS care programme in rural Uganda. Lancet 368 :1587–1594.
-
8
Braitstein P, Brinkhof MW, Dabis F, Schechter M, Boulle A, Miotti P, Wood R, Laurent C, Sprinz E, Seyler C, Bangsberg DR, Balestre E, Sterne JA, May M, Egger M, 2006. Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet 367 :817–824.
-
9
Coetzee D, Boulle A, Hildebrand K, Asselman V, Van Cutsem G, Goemaere E, 2004. Promoting adherence to antiretroviral therapy: the experience from a primary care setting in Khayelitsha, South Africa. AIDS 18 (Suppl 3):S27–S31.
-
10
Laurent C, Kouanfack C, Vergne L, Tardy M, Zekeng L, Noumsi N, Butel C, Bourgeois A, Mpoudi-Ngole E, Koulla-Shiro S, Peeters M, Delaporte E, 2006. Antiretroviral drug resistance and routine therapy, Cameroon. Emerg Infect Dis 12 :1001–1004.
-
11
Mills EJ, Nachega JB, Buchan I, Orbinski J, Attaran A, Singh S, Rachlis B, Wu P, Cooper C, Thabane L, Wilson K, Guyatt GH, Bangsberg DR, 2006. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA 296 :679–690.
-
12
van Oosterhout JJ, Bodasing N, Kumwenda JJ, Nyirenda C, Mallewa J, Cleary PR, de Baar MP, Schuurman R, Burger DM, Zijlstra EE, 2005. Evaluation of antiretroviral therapy results in a resource-poor setting in Blantyre, Malawi. Trop Med Int Health 10 :464–470.
-
13
Crane JT, Kawuma A, Oyugi JH, Byakika JT, Moss A, Bourgois P, Bangsberg DR, 2006. The price of adherence: qualitative findings from HIV positive individuals purchasing fixed-dose combination generic HIV antiretroviral therapy in Kampala, Uganda. AIDS Behav 10 :437–442.
-
14
(ZNAC) ZNAC, 2004. National Guidelines for Management and Care of Patients with HIV/AIDS. Lusaka, Zambia: Printech Press.
-
15
Chesney M, 2003. Adherence to HAART regimens. AIDS Patient Care STDS 17 :169–177.
-
16
WorldBank, 2007. Urbanization. Available at: http://siteresources.worldbank.org/DATASTATISTICS/Resources/table3_10.pdf. Accessed August 15, 2008.
-
17
CSO, 2003. Zambia Demographic & Health Survey 2001–2003. CSO CBoHOM. Zambia: Central Statistical Office.
-
18
Zulu I, Schuman P, Musonda R, Chomba E, Mwinga K, Sinkala M, Chisembele M, Mwaba P, Kasonde D, Vermund SH, 2004. Priorities for antiretroviral therapy research in sub-Saharan Africa: a 2002 consensus conference in Zambia. J Acquir Immune Defic Syndr 36 :831–834.
-
19
Oyugi JH, Byakika-Tusiime J, Charlebois ED, Kityo C, Mugerwa R, Mugyenyi P, Bangsberg DR, 2004. Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resource-limited setting. J Acquir Immune Defic Syndr 36 :1100–1102.
-
20
Nachega JB, Knowlton AR, Deluca A, Schoeman JH, Watkinson L, Efron A, Chaisson RE, Maartens G, 2006. Treatment supporter to improve adherence to antiretroviral therapy in HIV-infected South African adults. A qualitative study. J Acquir Immune Defic Syndr 43 (Suppl 1):S127–S133.
-
21
Stringer JS, Zulu I, Levy J, Stringer EM, Mwango A, Chi BH, Mtonga V, Reid S, Cantrell RA, Bulterys M, Saag MS, Marlink RG, Mwinga A, Ellerbrock TV, Sinkala M, 2006. Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: feasibility and early outcomes. JAMA 296 :782–793.
-
22
Degefa A, Sanders EJ, Mekonnen Y, Messele T, Wolday D, Dorigo-Zetsma W, Mekonnen W, Schaap A, Dukers NH, 2003. Knowledge and attitudes towards antiretroviral therapy among factory workers participating in a cohort on HIV and AIDS, Addis Ababa, Ethiopia. Ethiop Med J 41 (Suppl 1):75–87.
-
23
Norman A, Chopra M, Kadiyala S, 2007. Factors related to HIV disclosure in 2 South African communities. Am J Public Health 97 :1775–1781.
-
24
Hays RB, McKusick L, Pollack L, Hilliard R, Hoff C, Coates TJ, 1993. Disclosing HIV seropositivity to significant others. AIDS 7 :425–431.
-
25
Kalichman SC, DiMarco M, Austin J, Luke W, DiFonzo K, 2003. Stress, social support, and HIV-status disclosure to family and friends among HIV-positive men and women. J Behav Med 26 :315–332.
-
26
Larsson EC, Okong P, Thorson A, Ekstrom AM, 2007. Antiretroviral treatment of HIV in Uganda: a comparison of three different delivery models in a single hospital. Trans R Soc Trop Med Hyg 101 :885–892.
-
27
Watch HR, 2008. Hidden in the mealie meal: gender-based abuses and women’s HIV treatment in Zambia. Available at: http://hrw.org/reports/2007/zambia1207/zambia1207webwcover.pdf. Accessed January 15, 2009.
-
28
Katamba A, Neuhauser DB, Smyth KA, Adatu F, Katabira E, Whalen CC, 2005. Patients perceived stigma associated with community-based directly observed therapy of tuberculosis in Uganda. East Afr Med J 82 :337–342.
-
29
Ngamvithayapong J, Yanai H, Winkvist A, Saisorn S, Diwan V, 2001. Feasibility of home-based and health centre-based DOT: perspectives of TB care providers and clients in an HIV-endemic area of Thailand. Int J Tuberc Lung Dis 5 :741–745.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 28 | 28 | 6 |
| Full Text Views | 309 | 70 | 0 |
| PDF Downloads | 84 | 14 | 0 |
Antiretroviral Adherence in Rural Zambia: The First Year of Treatment Availability
Gretchen L. Birbeck
Gretchen L. Birbeck
International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; Chikankata Health Services, Mazabuka, Zambia; Department of Paediatrics and Child Health, University of Zambia, Lusaka, Zambia; Michigan State University College of Osteopathic Medicine, East Lansing, Michigan; Michigan State University College of Human Medicine, East Lansing, Michigan; Monze Mission Hospital, Monze, Zambia; Provincial Health Office, Eastern Province, Chipata, Zambia
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Elwyn Chomba
Elwyn Chomba
International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; Chikankata Health Services, Mazabuka, Zambia; Department of Paediatrics and Child Health, University of Zambia, Lusaka, Zambia; Michigan State University College of Osteopathic Medicine, East Lansing, Michigan; Michigan State University College of Human Medicine, East Lansing, Michigan; Monze Mission Hospital, Monze, Zambia; Provincial Health Office, Eastern Province, Chipata, Zambia
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Michelle Kvalsund
Michelle Kvalsund
International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; Chikankata Health Services, Mazabuka, Zambia; Department of Paediatrics and Child Health, University of Zambia, Lusaka, Zambia; Michigan State University College of Osteopathic Medicine, East Lansing, Michigan; Michigan State University College of Human Medicine, East Lansing, Michigan; Monze Mission Hospital, Monze, Zambia; Provincial Health Office, Eastern Province, Chipata, Zambia
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Richard Bradbury
Richard Bradbury
International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; Chikankata Health Services, Mazabuka, Zambia; Department of Paediatrics and Child Health, University of Zambia, Lusaka, Zambia; Michigan State University College of Osteopathic Medicine, East Lansing, Michigan; Michigan State University College of Human Medicine, East Lansing, Michigan; Monze Mission Hospital, Monze, Zambia; Provincial Health Office, Eastern Province, Chipata, Zambia
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Charles Mang’ombe
Charles Mang’ombe
International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; Chikankata Health Services, Mazabuka, Zambia; Department of Paediatrics and Child Health, University of Zambia, Lusaka, Zambia; Michigan State University College of Osteopathic Medicine, East Lansing, Michigan; Michigan State University College of Human Medicine, East Lansing, Michigan; Monze Mission Hospital, Monze, Zambia; Provincial Health Office, Eastern Province, Chipata, Zambia
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Kennedy Malama
Kennedy Malama
International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; Chikankata Health Services, Mazabuka, Zambia; Department of Paediatrics and Child Health, University of Zambia, Lusaka, Zambia; Michigan State University College of Osteopathic Medicine, East Lansing, Michigan; Michigan State University College of Human Medicine, East Lansing, Michigan; Monze Mission Hospital, Monze, Zambia; Provincial Health Office, Eastern Province, Chipata, Zambia
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Trevor Kaile
Trevor Kaile
International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; Chikankata Health Services, Mazabuka, Zambia; Department of Paediatrics and Child Health, University of Zambia, Lusaka, Zambia; Michigan State University College of Osteopathic Medicine, East Lansing, Michigan; Michigan State University College of Human Medicine, East Lansing, Michigan; Monze Mission Hospital, Monze, Zambia; Provincial Health Office, Eastern Province, Chipata, Zambia
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Peter A. Byers
Peter A. Byers
International Neurologic and Psychiatric Epidemiology Program, Michigan State University, East Lansing, Michigan; Chikankata Health Services, Mazabuka, Zambia; Department of Paediatrics and Child Health, University of Zambia, Lusaka, Zambia; Michigan State University College of Osteopathic Medicine, East Lansing, Michigan; Michigan State University College of Human Medicine, East Lansing, Michigan; Monze Mission Hospital, Monze, Zambia; Provincial Health Office, Eastern Province, Chipata, Zambia
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We conducted a retrospective chart review of antiretroviral therapy (ART) clinic patients treated during the first 12 months after clinics opened in rural Zambia and assessed adherence based on clinic attendance, patient report, and staff assessment. We identified 255 eligible patients (mean age, 39.7 years; 44.3% male; 56.5% married; and 45.5% with only primary school education). Twenty percent had partners known to be HIV positive. Twenty percent were widowed. Thirty-seven percent had disclosed their HIV status to their spouse. Disclosure was less likely among women (27.5% versus 49.6%, P = 0.0005); 36.5% had “clinic buddies” to provide adherence support. Adherence rates were good for 59.2%. Disclosure of HIV status to ones’ spouse (P = 0.047), knowing spouses’ HIV status (P = 0.02), and having a clinic buddy (P = 0.01) were associated with good adherence. Social support is a key patient-level resource impacting ART adherence in rural Zambia. Limited spousal disclosure affects women more than men. Clinic buddies are associated with better adherence.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1
UNAIDS, 2004. Available at: http://whqlibdea.who.int/unaids/2004/9291733903.pdf. Accessed August 15, 2008.
-
2
WHO, 2007. UNAIDS Fact Sheet-Revised HIV estimates. Availableat:http://data.unaids.org/pub/EPISlides/2007/071118_epi_revisions_factsheet_en.pdf. Accessed August 15, 2008.
-
3
Harries AD, Nyangulu DS, Hargreaves NJ, Kaluwa O, Salaniponi FM, 2001. Preventing antiretroviral anarchy in sub-Saharan Africa. Lancet 358 :410–414.
-
4
Wools-Kaloustian K, Kimaiyo S, Diero L, Siika A, Sidle J, Yiannoutsos CT, Musick B, Einterz R, Fife KH, Tierney WM, 2006. Viability and effectiveness of large-scale HIV treatment initiatives in sub-Saharan Africa: experience from western Kenya. AIDS 20 :41–48.
-
5
Nachega JB, Stein DM, Lehman DA, Hlatshwayo D, Mothopeng R, Chaisson RE, Karstaedt AS, 2004. Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. AIDS Res Hum Retroviruses 20 :1053–1056.
-
6
Marazzi MC, Bartolo M, Emberti Gialloreti L, Germano P, Guidotti G, Liotta G, Magnano San Lio M, Mancinelli S, Modolo MA, Narciso P, Perno CF, Scarcella P, Tintisona G, Palombi L, 2006. Improving adherence to highly active anti-retroviral therapy in Africa: the DREAM programme in Mozambique. Health Educ Res 21 :34–42.
-
7
Weidle PJ, Wamai N, Solberg P, Liechty C, Sendagala S, Were W, Mermin J, Buchacz K, Behumbiize P, Ransom RL, Bunnell R, 2006. Adherence to antiretroviral therapy in a home-based AIDS care programme in rural Uganda. Lancet 368 :1587–1594.
-
8
Braitstein P, Brinkhof MW, Dabis F, Schechter M, Boulle A, Miotti P, Wood R, Laurent C, Sprinz E, Seyler C, Bangsberg DR, Balestre E, Sterne JA, May M, Egger M, 2006. Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet 367 :817–824.
-
9
Coetzee D, Boulle A, Hildebrand K, Asselman V, Van Cutsem G, Goemaere E, 2004. Promoting adherence to antiretroviral therapy: the experience from a primary care setting in Khayelitsha, South Africa. AIDS 18 (Suppl 3):S27–S31.
-
10
Laurent C, Kouanfack C, Vergne L, Tardy M, Zekeng L, Noumsi N, Butel C, Bourgeois A, Mpoudi-Ngole E, Koulla-Shiro S, Peeters M, Delaporte E, 2006. Antiretroviral drug resistance and routine therapy, Cameroon. Emerg Infect Dis 12 :1001–1004.
-
11
Mills EJ, Nachega JB, Buchan I, Orbinski J, Attaran A, Singh S, Rachlis B, Wu P, Cooper C, Thabane L, Wilson K, Guyatt GH, Bangsberg DR, 2006. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA 296 :679–690.
-
12
van Oosterhout JJ, Bodasing N, Kumwenda JJ, Nyirenda C, Mallewa J, Cleary PR, de Baar MP, Schuurman R, Burger DM, Zijlstra EE, 2005. Evaluation of antiretroviral therapy results in a resource-poor setting in Blantyre, Malawi. Trop Med Int Health 10 :464–470.
-
13
Crane JT, Kawuma A, Oyugi JH, Byakika JT, Moss A, Bourgois P, Bangsberg DR, 2006. The price of adherence: qualitative findings from HIV positive individuals purchasing fixed-dose combination generic HIV antiretroviral therapy in Kampala, Uganda. AIDS Behav 10 :437–442.
-
14
(ZNAC) ZNAC, 2004. National Guidelines for Management and Care of Patients with HIV/AIDS. Lusaka, Zambia: Printech Press.
-
15
Chesney M, 2003. Adherence to HAART regimens. AIDS Patient Care STDS 17 :169–177.
-
16
WorldBank, 2007. Urbanization. Available at: http://siteresources.worldbank.org/DATASTATISTICS/Resources/table3_10.pdf. Accessed August 15, 2008.
-
17
CSO, 2003. Zambia Demographic & Health Survey 2001–2003. CSO CBoHOM. Zambia: Central Statistical Office.
-
18
Zulu I, Schuman P, Musonda R, Chomba E, Mwinga K, Sinkala M, Chisembele M, Mwaba P, Kasonde D, Vermund SH, 2004. Priorities for antiretroviral therapy research in sub-Saharan Africa: a 2002 consensus conference in Zambia. J Acquir Immune Defic Syndr 36 :831–834.
-
19
Oyugi JH, Byakika-Tusiime J, Charlebois ED, Kityo C, Mugerwa R, Mugyenyi P, Bangsberg DR, 2004. Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resource-limited setting. J Acquir Immune Defic Syndr 36 :1100–1102.
-
20
Nachega JB, Knowlton AR, Deluca A, Schoeman JH, Watkinson L, Efron A, Chaisson RE, Maartens G, 2006. Treatment supporter to improve adherence to antiretroviral therapy in HIV-infected South African adults. A qualitative study. J Acquir Immune Defic Syndr 43 (Suppl 1):S127–S133.
-
21
Stringer JS, Zulu I, Levy J, Stringer EM, Mwango A, Chi BH, Mtonga V, Reid S, Cantrell RA, Bulterys M, Saag MS, Marlink RG, Mwinga A, Ellerbrock TV, Sinkala M, 2006. Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: feasibility and early outcomes. JAMA 296 :782–793.
-
22
Degefa A, Sanders EJ, Mekonnen Y, Messele T, Wolday D, Dorigo-Zetsma W, Mekonnen W, Schaap A, Dukers NH, 2003. Knowledge and attitudes towards antiretroviral therapy among factory workers participating in a cohort on HIV and AIDS, Addis Ababa, Ethiopia. Ethiop Med J 41 (Suppl 1):75–87.
-
23
Norman A, Chopra M, Kadiyala S, 2007. Factors related to HIV disclosure in 2 South African communities. Am J Public Health 97 :1775–1781.
-
24
Hays RB, McKusick L, Pollack L, Hilliard R, Hoff C, Coates TJ, 1993. Disclosing HIV seropositivity to significant others. AIDS 7 :425–431.
-
25
Kalichman SC, DiMarco M, Austin J, Luke W, DiFonzo K, 2003. Stress, social support, and HIV-status disclosure to family and friends among HIV-positive men and women. J Behav Med 26 :315–332.
-
26
Larsson EC, Okong P, Thorson A, Ekstrom AM, 2007. Antiretroviral treatment of HIV in Uganda: a comparison of three different delivery models in a single hospital. Trans R Soc Trop Med Hyg 101 :885–892.
-
27
Watch HR, 2008. Hidden in the mealie meal: gender-based abuses and women’s HIV treatment in Zambia. Available at: http://hrw.org/reports/2007/zambia1207/zambia1207webwcover.pdf. Accessed January 15, 2009.
-
28
Katamba A, Neuhauser DB, Smyth KA, Adatu F, Katabira E, Whalen CC, 2005. Patients perceived stigma associated with community-based directly observed therapy of tuberculosis in Uganda. East Afr Med J 82 :337–342.
-
29
Ngamvithayapong J, Yanai H, Winkvist A, Saisorn S, Diwan V, 2001. Feasibility of home-based and health centre-based DOT: perspectives of TB care providers and clients in an HIV-endemic area of Thailand. Int J Tuberc Lung Dis 5 :741–745.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 28 | 28 | 6 |
| Full Text Views | 309 | 70 | 0 |
| PDF Downloads | 84 | 14 | 0 |