Evaluation of Nitazoxanide and Oxfendazole Efficacy against Cystic Echinococcosis in Naturally Infected Sheep

Cesar M. Gavidia Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Facultad de Ciencias, Lima, Peru; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland

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Armando E. Gonzalez Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Facultad de Ciencias, Lima, Peru; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland

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Luis Lopera Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Facultad de Ciencias, Lima, Peru; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland

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Cesar Jayashi Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Facultad de Ciencias, Lima, Peru; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland

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Roxana Angelats Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Facultad de Ciencias, Lima, Peru; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland

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Eduardo A. Barron Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Facultad de Ciencias, Lima, Peru; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland

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Berenice Ninaquispe Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Facultad de Ciencias, Lima, Peru; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland

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Lucia Villarreal Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Facultad de Ciencias, Lima, Peru; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland

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Hector H. Garcia Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Facultad de Ciencias, Lima, Peru; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland

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Manuela R. Verastegui Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Facultad de Ciencias, Lima, Peru; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland

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Robert H. Gilman Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Peru; Universidad Peruana Cayetano Heredia, Facultad de Ciencias, Lima, Peru; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland

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Cystic echinococosis (CE) is a public health problem caused by Echinococcus granulosus. We aimed to determine the efficacy of nitazoxanide (NTZ) and oxfendazole (OXF) against CE in naturally infected sheep. A total of 151 ewes were assigned to the following groups: 15 mg/kg of NTZ weekly for five weeks (NTZ5); two rounds of 15 mg/ kg of NTZ a day for five days (NTZ5×2) two weeks apart; 30 mg/kg of OXF a week for 11 weeks (OXF11); 30 mg/kg of OXF plus 15 mg/kg of NTZ a week for 11 weeks (OXF/NTZ); and the control group. OXF11 and OXF/NTZ decreased the number of fertile cysts, increased the number of degenerated cysts, and were more efficacious (49.6–61.2%) against lung cysts and liver cysts (91.8–100%) than any other treatment group. OXF might be an additional strategy for control programs and an optional treatment of human CE after it is licensed.

Author Notes

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