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1
Zijlstra EE, El-Hassan AM, 2001. Leishmaniasis in Sudan: post-kala-azar dermal leishmaniasis. Tran R Soc Trop Med Hyg 95 (Suppl 1):S59–S76.
-
2
Dutta M, Ghosh TK, 1983. Review of current status of leishmaniasis epidemiology, Proceedings of the Indo-UK Workshop on Leishmaniasis, New Delhi: Indian Council of Medical Research: 97–102.
-
3
World Health Organization, 1978. A Decade of Health Development in South-east Asia. South-east Asia Regional Publication Series No. 7. New Delhi: World Health Organization.
-
4
Ranjan A, Sur D, Singh VP, Siddique NA, Manna B, Lal CS, Sinha PK, Kishore K, Bhattacharya SK, 2005. Risk factors for Indian kala-azar. Am J Trop Med Hyg 73 :74–78.
-
5
Bhattacharya SK, Sinha PK, Sunder S, Thakur CP, Jha TK, Pandey K, Das VNR, Kumar N, Lal CS, Verma N, Singh VP, Ranjan A, Verma RK, Anders G, Sindermann H, Ganguly NK, 2007. Phase 4 trial of miltefosine for the treatment of Indian visceral leishmaniasis. J Infect Dis 196 :591–598.
-
6
Sharma MC, Gupta AK, Verma N, Das VN, Saran R, Kar SK, 2000. Demonstration of Leishmania parasites in skin lesions of Indian post kala-azar dermal leishmaniasis (PKDL) cases. J Commun Dis 32 :67–68.
-
7
Salotra P, Singh R, 2006. Challenges in the diagnosis of post kala-azar dermal leishmaniasis. Indian J Med Res 123 :295–310.
-
8
Das VNR, Ranjan A, Bimal S, Siddique NA, Pandey K, Kumar N, Verma N, Singh VP, Sinha PK, Bhattacharya SK, 2005. Magnitude of unresponsiveness to sodium stibogluconate in the treatment of visceral leishmaniasis in Bihar. Natl Med J India 18 :131–133.
-
9
Thakur CP, Narain S, Kumar N, Hasaan SM, Jha DK, Kumar A, 1997. Amphotericin B is superior to sodium antimony glucon-ate in the treatment of Indian post kala-azar dermal leishmaniasis. Ann Trop Med Parasitol 91 :611–616.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 17 | 17 | 4 |
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Development of Post–Kala-Azar Dermal Leishmaniasis (PKDL) in Miltefosine-Treated Visceral Leishmaniasis
Vidya Nand Rabi Das
Vidya Nand Rabi Das
Division of Clinical Medicine, Division of Pathology, Division of Biochemistry, Division of Immunology, Division of Epidemiology, Division of Microbiology and Molecular Biology, and Division of Biostatistics, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India
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Krishna Pandey
Krishna Pandey
Division of Clinical Medicine, Division of Pathology, Division of Biochemistry, Division of Immunology, Division of Epidemiology, Division of Microbiology and Molecular Biology, and Division of Biostatistics, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India
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Neena Verma
Neena Verma
Division of Clinical Medicine, Division of Pathology, Division of Biochemistry, Division of Immunology, Division of Epidemiology, Division of Microbiology and Molecular Biology, and Division of Biostatistics, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India
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Chandra Shekhar Lal
Chandra Shekhar Lal
Division of Clinical Medicine, Division of Pathology, Division of Biochemistry, Division of Immunology, Division of Epidemiology, Division of Microbiology and Molecular Biology, and Division of Biostatistics, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India
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Sanjeev Bimal
Sanjeev Bimal
Division of Clinical Medicine, Division of Pathology, Division of Biochemistry, Division of Immunology, Division of Epidemiology, Division of Microbiology and Molecular Biology, and Division of Biostatistics, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India
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Roshan Kamal Topno
Roshan Kamal Topno
Division of Clinical Medicine, Division of Pathology, Division of Biochemistry, Division of Immunology, Division of Epidemiology, Division of Microbiology and Molecular Biology, and Division of Biostatistics, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India
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Dharmendra Singh
Dharmendra Singh
Division of Clinical Medicine, Division of Pathology, Division of Biochemistry, Division of Immunology, Division of Epidemiology, Division of Microbiology and Molecular Biology, and Division of Biostatistics, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India
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Niyamat Ali Siddiqui
Niyamat Ali Siddiqui
Division of Clinical Medicine, Division of Pathology, Division of Biochemistry, Division of Immunology, Division of Epidemiology, Division of Microbiology and Molecular Biology, and Division of Biostatistics, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India
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Rakesh Bihari Verma
Rakesh Bihari Verma
Division of Clinical Medicine, Division of Pathology, Division of Biochemistry, Division of Immunology, Division of Epidemiology, Division of Microbiology and Molecular Biology, and Division of Biostatistics, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India
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Pradeep Das
Pradeep Das
Division of Clinical Medicine, Division of Pathology, Division of Biochemistry, Division of Immunology, Division of Epidemiology, Division of Microbiology and Molecular Biology, and Division of Biostatistics, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India
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We report two cases of post–kala-azar dermal leishmaniasis (PKDL), which had subsequently developed after successful treatment of visceral leishmaniasis with miltefosine. Both patients had maculo-nodular lesions all over the body, and they were diagnosed as PKDL by parasitologic examination for Leishmania donovani bodies in a skin snip of lesions. Patients were put on amphotericin B and responded very well for nodular lesions with one course of treatment. However, longer duration of the treatment is needed for total clearance of macular lesions from body surface in PKDL cases. This is the first case report of PKDL in India, which developed after successful treatment of visceral leishmaniasis with miltefosine.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1
Zijlstra EE, El-Hassan AM, 2001. Leishmaniasis in Sudan: post-kala-azar dermal leishmaniasis. Tran R Soc Trop Med Hyg 95 (Suppl 1):S59–S76.
-
2
Dutta M, Ghosh TK, 1983. Review of current status of leishmaniasis epidemiology, Proceedings of the Indo-UK Workshop on Leishmaniasis, New Delhi: Indian Council of Medical Research: 97–102.
-
3
World Health Organization, 1978. A Decade of Health Development in South-east Asia. South-east Asia Regional Publication Series No. 7. New Delhi: World Health Organization.
-
4
Ranjan A, Sur D, Singh VP, Siddique NA, Manna B, Lal CS, Sinha PK, Kishore K, Bhattacharya SK, 2005. Risk factors for Indian kala-azar. Am J Trop Med Hyg 73 :74–78.
-
5
Bhattacharya SK, Sinha PK, Sunder S, Thakur CP, Jha TK, Pandey K, Das VNR, Kumar N, Lal CS, Verma N, Singh VP, Ranjan A, Verma RK, Anders G, Sindermann H, Ganguly NK, 2007. Phase 4 trial of miltefosine for the treatment of Indian visceral leishmaniasis. J Infect Dis 196 :591–598.
-
6
Sharma MC, Gupta AK, Verma N, Das VN, Saran R, Kar SK, 2000. Demonstration of Leishmania parasites in skin lesions of Indian post kala-azar dermal leishmaniasis (PKDL) cases. J Commun Dis 32 :67–68.
-
7
Salotra P, Singh R, 2006. Challenges in the diagnosis of post kala-azar dermal leishmaniasis. Indian J Med Res 123 :295–310.
-
8
Das VNR, Ranjan A, Bimal S, Siddique NA, Pandey K, Kumar N, Verma N, Singh VP, Sinha PK, Bhattacharya SK, 2005. Magnitude of unresponsiveness to sodium stibogluconate in the treatment of visceral leishmaniasis in Bihar. Natl Med J India 18 :131–133.
-
9
Thakur CP, Narain S, Kumar N, Hasaan SM, Jha DK, Kumar A, 1997. Amphotericin B is superior to sodium antimony glucon-ate in the treatment of Indian post kala-azar dermal leishmaniasis. Ann Trop Med Parasitol 91 :611–616.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 17 | 17 | 4 |
| Full Text Views | 346 | 66 | 0 |
| PDF Downloads | 87 | 14 | 0 |