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Hepato-Splenic Schistosomiasis in Mice
William B. DeWitt
William B. DeWitt
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland
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Kenneth S Warren
Kenneth S Warren
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland
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Summary
A syndrome that closely resembles hepatosplenic schistosomiasis in humans developed in mice following infection with Schistosoma mansoni. Data obtained from the infected mice suggest that the pathogenesis of the syndrome was related to the penetration of the portal canals of the liver by large numbers of schistosome eggs which incite granulomatous reactions and obstruction of portal blood flow. This in turn produces portal hypertension and the development of congestive hepato-splenomegaly, esophageal varices and ascites. Histologically there was little damage to the liver parenchyma, which is further borne out by very little liver function test derangement. A severe anemia developed in some of the infected mice (4 to 6 gm per cent hemoglobin).
Author Notes
Laboratory of Parasitic Diseases.
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