An Attempt to Eradicate Malaria by the Weekly Administration of Pyrimethamine in Areas of Out-of-Doors Transmission in Venezuela

Arnoldo Gabaldon Division de Malariologia, Direccion de Salud Publica, Ministerio de Sanidad y Asistencia Social, Maracay, Aragua, Venezuela

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Lacenio Guerrero Division de Malariologia, Direccion de Salud Publica, Ministerio de Sanidad y Asistencia Social, Maracay, Aragua, Venezuela

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C. Balestrini Division de Malariologia, Direccion de Salud Publica, Ministerio de Sanidad y Asistencia Social, Maracay, Aragua, Venezuela

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B. Garcia Martin Division de Malariologia, Direccion de Salud Publica, Ministerio de Sanidad y Asistencia Social, Maracay, Aragua, Venezuela

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R. Grossi Division de Malariologia, Direccion de Salud Publica, Ministerio de Sanidad y Asistencia Social, Maracay, Aragua, Venezuela

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S. Maberti Division de Malariologia, Direccion de Salud Publica, Ministerio de Sanidad y Asistencia Social, Maracay, Aragua, Venezuela

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T. Mendicoa Division de Malariologia, Direccion de Salud Publica, Ministerio de Sanidad y Asistencia Social, Maracay, Aragua, Venezuela

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C. Psinakis Division de Malariologia, Direccion de Salud Publica, Ministerio de Sanidad y Asistencia Social, Maracay, Aragua, Venezuela

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E. Russian Division de Malariologia, Direccion de Salud Publica, Ministerio de Sanidad y Asistencia Social, Maracay, Aragua, Venezuela

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V. Salterini Division de Malariologia, Direccion de Salud Publica, Ministerio de Sanidad y Asistencia Social, Maracay, Aragua, Venezuela

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M. Tabachiera Division de Malariologia, Direccion de Salud Publica, Ministerio de Sanidad y Asistencia Social, Maracay, Aragua, Venezuela

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A. Irigoyen Division de Malariologia, Direccion de Salud Publica, Ministerio de Sanidad y Asistencia Social, Maracay, Aragua, Venezuela

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DOI:
https://doi.org/10.4269/ajtmh.1959.8.433
Volume/Issue:
Volume 8: Issue 4
Page(s):
433–439
Restricted access
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Summary

Pyrimethamine was used in two areas of Venezuela with partially refractory malaria where the vectors were Anopheles aquasalis and Anopheles nunez-tovari.

During the months of July through December, 1957, a total of 111,995 people received pyrimethamine once weekly at a dose of 50 mg to adults and correspondingly smaller doses to children. The above dosages were eminently effective in stopping transmission as evidenced by the fact that no parasite-positive cases were found during the last three months of the project. Relapses appeared in both areas, however, after drug administration was stopped which showed that pyrimethamine as employed here did not produce suppressive cure of all vivax infections. It is hoped that pyrimethamine given at the same dosage and continued for a greater length of time in areas of partially refractory malaria will interrupt transmission until the infections die out.

Author Notes

The authors wish to thank Dr. Arturo Luis Berti, Chief of the Division, for the facilities and help given while the work was being carried out.

Published Online:
Jul 1959
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637

Diagnostic Procedures and Reagents

Technics for the Laboratory Diagnosis and Control of the Communicable Diseases, American Public Health Association, Ed., pp. v plus 589, 6 plates in color, cloth, New York, Am. Pub. Health Assoc. Inc., 1950, $6.00

An Introduction to Medical Protozoology

With Chapters on the Spirochaetes and on Laboratory Methods. By Robert Knowles, B.A., M.R.C.S., L.R.C.P., Lt. Col., Indian Medical Service, Calcutta. Thacker, Spink and Company. 1928. Pages I–XII, 1–887

Author:
Chas. F. Craig
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