Insecticide Resistance in Arthropods

by A. W. A. Brown. World Health Organization, Monograph Series No. 38. 240 pp., illustrated with figures and tables. WHO, Palais des Nations, Geneva, 1958. Price $5.00, U. S. A

Lloyd E. Rozeboom
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One of the most significant advances of recent years in the field of public health has been the discovery of the usefulness of DDT and other chlorinated hydrocarbons in the control of disease-bearing arthropods. As a result, it is now possible to organize programs against malaria and certain other diseases with eradication rather than control as the objective. However, in the past few years, almost 40 species of insects of public health importance have developed resistance to one or more of these compounds. In this book, Dr. Brown has presented a summary of all published and some unpublished information concerning insecticide resistance among these arthropods.

Evidence points to DDT resistance, due to DDT-dehydrochlorinase, as being controlled in most cases by a single gene. In other insects, several genes appear to be involved. The mechanism and genetics of resistance to the cyclodiene compounds are not so clear, although in some instances this too appears to be monofactorial.