ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Benedict MQ, Levine RS, Hawley WA, Lounibos LP, 2007. Spread of the tiger: global risk of invasion by the mosquito Aedes albopictus.Vector Borne Zoonotic Dis 7 :76–85.
-
2
O’Meara GF, Evans LF Jr, Gettman AD, Cuda JP, 1995. Spread of Aedes albopictus and decline of Ae. aegypti (Diptera: Culicidae) in Florida. J Med Entomol 32 :554–562.
-
3
Juliano SA, Lounibos LP, 2005. Ecology of invasive mosquitoes: effects on resident species and on human health. Ecol Lett 8 :558–574.
-
4
Werner EE, Gilliam JF, 1984. The ontogenetic niche and species interactions in size-structured populations. Ann Rev Ecol Systematics 15 :393–425.
-
5
Osenberg CW, Mittelbach GG, Wainwright PC, 1992. Two-stage life histories in fish: the interactions between juvenile competition and adult performance. Ecology 73 :255–267.
-
6
Relyea RA, Hoverman JT, 2003. The impact of larval predators and competitors on the morphology and fitness of juvenile treefrogs. Oecologia 134 :596–604.
-
7
Olson MH, 1996. Ontogenetic niche shifts in largemouth bass: variability and consequences for first-year growth. Ecology 77 :179–190.
-
8
Werner EE, Peacor SD, 2003. A review of trait-mediated indirect interactions in ecological communities. Ecology 84 :1083–1100.
-
9
Alto BW, Lounibos LP, Higgs S, Juliano SA, 2005. Larval competition differentially affects arbovirus infection in Aedes mosquitoes. Ecology 86 :3279–3288.
-
10
Dye C, 1986. Vectorial capacity: must we measure all its components? Parasitol Today 2 :203–208.
-
11
Haramis LD, 1985. Larval nutrition, adult body size, and the biology of Aedes triseriatus. Lounibos LP, Rey JR, Frank JH, eds. Ecology of Mosquitoes: Proceedings of a Workshop. Vero Beach, FL: Florida Medical Entomology Laboratory, 431–437.
-
12
Hawley WA, 1985. The effect of larval density on adult longevity of a mosquito, Aedes sierrensis: epidemiological consequences. J Anim Ecol 54 :955–964.
-
13
Nasci RC, 1986. The size of emerging and host-seeking Aedes aegypti and the relation of size to blood-feeding success in the field. J Am Mosq Control Assoc 2 :61–62.
-
14
Scott TW, Amerasinghe PH, Morrison AC, Lorenz LH, Clark GG, Strickman D, Kittayapong P, Edman JD, 2000. Longitudinal studies of Aedes aegypti (Diptera: Culicidae) in Thailand and Puerto Rico: blood feeding frequency. J Med Entomol 37 :89–101.
-
15
Woodring JL, Higgs S, Beaty BJ, 1996. Natural cycles of vector-borne pathogens. Beaty BJ, Marquardt WC, eds. The Biology of Disease Vectors. Niwot, CO: University Press of Colorado, 51–72.
-
16
Beernsten BT, James AA, Christensen BM, 2000. Genetics of mosquito vector competence. Microbiol Mol Biol Rev 64 :115–137.
-
17
Gomez-Machorro C, Bennett KE, del L Munoz M, Black WC, 2004. Quantitative trait loci affecting dengue midgut infection barriers in an advanced intercross line of Aedes aegypti.Insect Mol Biol 13 :637–648.
-
18
Anderson JR, Schneider JR, Grimstad PR, Severson DW, 2005. Quantitative genetics of vector competence for La Crosse virus and body size in Ochlerotatus hendersoni and Ochlerotatus triseriatus interspecific hybrids. Genetics 169 :1529–1539.
-
19
Bennett KE, Flick D, Fleming KH, Jochim R, Beaty BJ, Black WC, 2005. Quantitative trait loci that control dengue-2 virus dissemination in the mosquito Aedes aegypti.Genetics 170 :185–194.
-
20
Watts DM, Burke DS, Harrison BA, Whitmire RE, Nisalak A, 1987. Effect of temperature on the vector efficiency of Aedes aegypti for dengue 2 virus. Am J Trop Med Hyg 36 :143–152.
-
21
Reisen WK, Meyer RP, Presser SB, Hardy JL, 1993. Effect of temperature on the transmission of western equine encephalomyelitis and St. Louis encephalitis viruses by Culex tarsalis.J Med Entomol 30 :151–160.
-
22
Reisen WK, Fang Y, Martinez VM, 2006. Effects of temperature on the transmission of West Nile virus by Culex tarsalis (Diptera: Culicidae). J Med Entomol 43 :309–317.
-
23
Grimstad PR, Walker ED, 1991. Aedes triseriatus (Diptera: Culicidae) and LaCrosse virus. IV. Nutritional deprivation of larvae affects the adult barriers to infection and transmission. J Med Entomol 28 :378–386.
-
24
Grimstad PR, Haramis LD, 1984. Aedes triseriatus (Diptera: Culicidae) and LaCrosse virus. III. Enhanced oral transmission by nutrition-deprived mosquitoes. J Med Entomol 21 :249–256.
-
25
Patrican LA, DeFoliart GR, 1985. Lack of adverse effect of transovarially acquired La Crosse virus on the reproductive capacity of Aedes triseriatus (Diptera: Culicidae). J Med Entomol 22 :604–611.
-
26
Paulson SL, Hawley WA, 1991. Effect of body size on the vector competence of field and laboratory populations of Aedes triseriatus for La Crosse virus. J Am Mosq Control Assoc 7 :170– 175.
-
27
Nasci RS, Mitchell CJ, 1994. Larval diet, adult size, and susceptibility of Aedes aegypti (Diptera: Culicidae) to infection with Ross River virus. J Med Entomol 31 :123–126.
-
28
Sumanochitrapon W, Strickman D, Sithiprasasna R, Kittayapong P, Innis BL, 1998. Effect of size and geographic origin of Aedes aegypti on oral infection with Dengue-2 virus. Am J Trop Med Hyg 58 :283–286.
-
29
Kay BH, Edman JD, Fanning ID, Mottram P, 1989. Larval diet and the vector competence of Culex annulirostris (Diptera: Culicidae) for Murray Valley encephalitis virus. J Med Entomol 26 :487–488.
-
30
Reisen WK, Hardy JL, Presser SB, 1997. Effects of water quality on the vector competence of Culex tarsalis (Diptera: Culicidae) for Western Equine encephalomyelitis (Togaviridae) and St. Louis encephalitis (Flaviviridae) viruses. J Med Entomol 34 :631–643.
-
31
Alto BW, Lounibos LP, Mores CN, Reiskind MH, 2008. Larval competition alters susceptibility of adult Aedes mosquitoes to dengue infection. Proc R Soc Lond B Biol Sci 275 :463–471.
-
32
Richards SL, Pesko K, Alto BW, Mores CN, 2007. Reduced infection in mosquitoes exposed to blood meals containing previously frozen Flaviviruses. Virus Res 129 :224–227.
-
33
Alto BW, Lounibos LP, Juliano SA, 2003. Age-dependent blood-feeding of Aedes aegypti and Aedes albopictus on artificial and living hosts. J Am Mosq Control Assoc 19 :347–352.
-
34
Turell MJ, Gargan TP II, Bailey CL, 1984. Replication and dissemination of Rift Valley fever virus in Culex pipiens.Am J Trop Med Hyg 33 :176–181.
-
35
Callahan JD, Wu S-JL, Dion-Schultz A, Mangold BE, Peruski LF, Watts DM, Porter KR, Murphy GR, Suharyono W, King C-C, Hayes CG, Temenak JJ, 2001. Development and evaluation of serotype- and group-specific flourogenic reverse transcriptase PCR (TaqMan) assays for dengue virus. J Clin Microbiol 39 :4119–4124.
-
36
Bustin SA, 2000. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 25 :169–193.
-
37
SAS Institute, 2004. SAS/STAT® 9.1 User’s Guide. SAS Institute, Cary, NC.
-
38
Scheiner SM, 2001. MANOVA: multiple response variables and multispecies interactions. Scheiner SM, Gurevitch J, eds. Design and Analysis of Ecological Experiments. Second edition. Oxford, UK: Oxford University Press, 99–115.
-
39
Effler PV, Pang L, Kitsutani P, Vorndam V, Nakata M, Ayers T, Elm J, Tom T, Reiter P, Rigau-Perez JG, Hayes JM, Mills K, Napier M, Clark GG, Gubler DJ, 2005. Dengue Fever, Hawaii 2001–2002. Emerg Infect Dis 11 :742–749.
-
40
Almeida AP, Baptista SSSG, Sousa CAGCC, Nova MTLM, Ramos HC, Panella NA, Godsey M, Simões MJ, Anselmo ML, Komar N, Mitchell CJ, Ribeiro H, 2005. Bioecology and vectorial capacity of Aedes albopictus (Diptera: Culicidae) in Macao, China in relation to dengue virus transmission. J Med Entomol 42 :419–428.
-
41
Bosio CF, Beaty BJ, Black WC, 1998. Quantitative genetics of vector competence for dengue-2 virus in Aedes aegypti.Am J Trop Med Hyg 59 :965–970.
-
42
Agudelo-Silva F, Spielman A, 1984. Paradoxical effects of simulated larviciding on production of adult mosquitoes. Am J Trop Med Hyg 33 :1267–1269.
-
43
Wilson ML, Agudelo-Silva F, Spielman A, 1990. Increased abundance, size, and longevity of food-deprived mosquito populations exposed to a fungal larvicide. Am J Trop Med Hyg 43 :551–556.
-
44
Morin PJ, 1981. Predatory salamanders reverse the outcome of competition among three species of anuran tadpoles. Science 212 :1284–1286.
-
45
Chambers RC, 1985. Competition and predation among larvae of three species of treehole breeding mosquitoes. Lounibos LP, Rey JR, Frank JH, eds. Ecology of Mosquitoes: Proceedings of a Workshop. Vero Beach, FL: Florida Medical Entomology Laboratory, 25–53.
-
46
Grill CP, Juliano SA, 1996. Predicting species interactions based on behaviour: predation and competition in container-dwelling mosquitoes. J Anim Ecol 65 :63–76.
-
47
Alto BW, Griswold MW, Lounibos LP, 2005. Habitat complexity and sex-dependent predation of mosquito larvae in containers. Oecologia 146 :300–310.
-
48
Maciel-de-Freitas R, Codeço CT, Lourenço-de-Oliveira R, 2007. Body size-associated survival and dispersal rates of Aedes aegypti in Rio de Janeiro. Med Vet Entomol 21 :284–292.
-
49
Fish D, 1985. An analysis of adult size variation within natural mosquito populations. Lounibos LP, Rey JR, Frank JH, eds. Ecology of Mosquitoes: Proceedings of a Workshop. Vero Beach, FL: Florida Medical Entomology Laboratory, 419–429.
-
50
Schneider JR, Mori A, Romero-Severson J, Chadee DD, Severson DW, 2007. Investigations of dengue-2 susceptibility and body size among Aedes aegypti populations. Med Vet Entomol 21 :370–376.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 202 | 136 | 13 |
| Full Text Views | 344 | 6 | 0 |
| PDF Downloads | 120 | 5 | 0 |
Size Alters Susceptibility of Vectors to Dengue Virus Infection and Dissemination
Barry W. Alto
Barry W. Alto
Florida Medical Entomology Laboratory, University of Florida, Vero Beach, Florida
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Michael H. Reiskind
Michael H. Reiskind
Florida Medical Entomology Laboratory, University of Florida, Vero Beach, Florida
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L. Philip Lounibos
L. Philip Lounibos
Florida Medical Entomology Laboratory, University of Florida, Vero Beach, Florida
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The size of arthropod vectors may affect their ability to transmit pathogens. Here we test the hypothesis that body size alters the susceptibility of Aedes aegypti and Aedes albopictus mosquitoes to dengue virus (DENV) infection and subsequent dissemination throughout the body of the mosquito. After feeding on blood containing known quantities of virus, smaller-sized females were significantly more likely to become infected and to disseminate virus than larger individuals. The effects of size were stronger for Ae. aegypti and independent of rearing conditions. Ae. albopictus was more susceptible to DENV infection and had higher virus titer in the body than Ae. aegypti, yet infected Ae. aegypti disseminated DENV more readily than infected Ae. albopictus. These results are consistent with the concept that Ae. aegypti is a more competent vector of DENV and emphasize the importance of body size in determining adult infection parameters.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1
Benedict MQ, Levine RS, Hawley WA, Lounibos LP, 2007. Spread of the tiger: global risk of invasion by the mosquito Aedes albopictus.Vector Borne Zoonotic Dis 7 :76–85.
-
2
O’Meara GF, Evans LF Jr, Gettman AD, Cuda JP, 1995. Spread of Aedes albopictus and decline of Ae. aegypti (Diptera: Culicidae) in Florida. J Med Entomol 32 :554–562.
-
3
Juliano SA, Lounibos LP, 2005. Ecology of invasive mosquitoes: effects on resident species and on human health. Ecol Lett 8 :558–574.
-
4
Werner EE, Gilliam JF, 1984. The ontogenetic niche and species interactions in size-structured populations. Ann Rev Ecol Systematics 15 :393–425.
-
5
Osenberg CW, Mittelbach GG, Wainwright PC, 1992. Two-stage life histories in fish: the interactions between juvenile competition and adult performance. Ecology 73 :255–267.
-
6
Relyea RA, Hoverman JT, 2003. The impact of larval predators and competitors on the morphology and fitness of juvenile treefrogs. Oecologia 134 :596–604.
-
7
Olson MH, 1996. Ontogenetic niche shifts in largemouth bass: variability and consequences for first-year growth. Ecology 77 :179–190.
-
8
Werner EE, Peacor SD, 2003. A review of trait-mediated indirect interactions in ecological communities. Ecology 84 :1083–1100.
-
9
Alto BW, Lounibos LP, Higgs S, Juliano SA, 2005. Larval competition differentially affects arbovirus infection in Aedes mosquitoes. Ecology 86 :3279–3288.
-
10
Dye C, 1986. Vectorial capacity: must we measure all its components? Parasitol Today 2 :203–208.
-
11
Haramis LD, 1985. Larval nutrition, adult body size, and the biology of Aedes triseriatus. Lounibos LP, Rey JR, Frank JH, eds. Ecology of Mosquitoes: Proceedings of a Workshop. Vero Beach, FL: Florida Medical Entomology Laboratory, 431–437.
-
12
Hawley WA, 1985. The effect of larval density on adult longevity of a mosquito, Aedes sierrensis: epidemiological consequences. J Anim Ecol 54 :955–964.
-
13
Nasci RC, 1986. The size of emerging and host-seeking Aedes aegypti and the relation of size to blood-feeding success in the field. J Am Mosq Control Assoc 2 :61–62.
-
14
Scott TW, Amerasinghe PH, Morrison AC, Lorenz LH, Clark GG, Strickman D, Kittayapong P, Edman JD, 2000. Longitudinal studies of Aedes aegypti (Diptera: Culicidae) in Thailand and Puerto Rico: blood feeding frequency. J Med Entomol 37 :89–101.
-
15
Woodring JL, Higgs S, Beaty BJ, 1996. Natural cycles of vector-borne pathogens. Beaty BJ, Marquardt WC, eds. The Biology of Disease Vectors. Niwot, CO: University Press of Colorado, 51–72.
-
16
Beernsten BT, James AA, Christensen BM, 2000. Genetics of mosquito vector competence. Microbiol Mol Biol Rev 64 :115–137.
-
17
Gomez-Machorro C, Bennett KE, del L Munoz M, Black WC, 2004. Quantitative trait loci affecting dengue midgut infection barriers in an advanced intercross line of Aedes aegypti.Insect Mol Biol 13 :637–648.
-
18
Anderson JR, Schneider JR, Grimstad PR, Severson DW, 2005. Quantitative genetics of vector competence for La Crosse virus and body size in Ochlerotatus hendersoni and Ochlerotatus triseriatus interspecific hybrids. Genetics 169 :1529–1539.
-
19
Bennett KE, Flick D, Fleming KH, Jochim R, Beaty BJ, Black WC, 2005. Quantitative trait loci that control dengue-2 virus dissemination in the mosquito Aedes aegypti.Genetics 170 :185–194.
-
20
Watts DM, Burke DS, Harrison BA, Whitmire RE, Nisalak A, 1987. Effect of temperature on the vector efficiency of Aedes aegypti for dengue 2 virus. Am J Trop Med Hyg 36 :143–152.
-
21
Reisen WK, Meyer RP, Presser SB, Hardy JL, 1993. Effect of temperature on the transmission of western equine encephalomyelitis and St. Louis encephalitis viruses by Culex tarsalis.J Med Entomol 30 :151–160.
-
22
Reisen WK, Fang Y, Martinez VM, 2006. Effects of temperature on the transmission of West Nile virus by Culex tarsalis (Diptera: Culicidae). J Med Entomol 43 :309–317.
-
23
Grimstad PR, Walker ED, 1991. Aedes triseriatus (Diptera: Culicidae) and LaCrosse virus. IV. Nutritional deprivation of larvae affects the adult barriers to infection and transmission. J Med Entomol 28 :378–386.
-
24
Grimstad PR, Haramis LD, 1984. Aedes triseriatus (Diptera: Culicidae) and LaCrosse virus. III. Enhanced oral transmission by nutrition-deprived mosquitoes. J Med Entomol 21 :249–256.
-
25
Patrican LA, DeFoliart GR, 1985. Lack of adverse effect of transovarially acquired La Crosse virus on the reproductive capacity of Aedes triseriatus (Diptera: Culicidae). J Med Entomol 22 :604–611.
-
26
Paulson SL, Hawley WA, 1991. Effect of body size on the vector competence of field and laboratory populations of Aedes triseriatus for La Crosse virus. J Am Mosq Control Assoc 7 :170– 175.
-
27
Nasci RS, Mitchell CJ, 1994. Larval diet, adult size, and susceptibility of Aedes aegypti (Diptera: Culicidae) to infection with Ross River virus. J Med Entomol 31 :123–126.
-
28
Sumanochitrapon W, Strickman D, Sithiprasasna R, Kittayapong P, Innis BL, 1998. Effect of size and geographic origin of Aedes aegypti on oral infection with Dengue-2 virus. Am J Trop Med Hyg 58 :283–286.
-
29
Kay BH, Edman JD, Fanning ID, Mottram P, 1989. Larval diet and the vector competence of Culex annulirostris (Diptera: Culicidae) for Murray Valley encephalitis virus. J Med Entomol 26 :487–488.
-
30
Reisen WK, Hardy JL, Presser SB, 1997. Effects of water quality on the vector competence of Culex tarsalis (Diptera: Culicidae) for Western Equine encephalomyelitis (Togaviridae) and St. Louis encephalitis (Flaviviridae) viruses. J Med Entomol 34 :631–643.
-
31
Alto BW, Lounibos LP, Mores CN, Reiskind MH, 2008. Larval competition alters susceptibility of adult Aedes mosquitoes to dengue infection. Proc R Soc Lond B Biol Sci 275 :463–471.
-
32
Richards SL, Pesko K, Alto BW, Mores CN, 2007. Reduced infection in mosquitoes exposed to blood meals containing previously frozen Flaviviruses. Virus Res 129 :224–227.
-
33
Alto BW, Lounibos LP, Juliano SA, 2003. Age-dependent blood-feeding of Aedes aegypti and Aedes albopictus on artificial and living hosts. J Am Mosq Control Assoc 19 :347–352.
-
34
Turell MJ, Gargan TP II, Bailey CL, 1984. Replication and dissemination of Rift Valley fever virus in Culex pipiens.Am J Trop Med Hyg 33 :176–181.
-
35
Callahan JD, Wu S-JL, Dion-Schultz A, Mangold BE, Peruski LF, Watts DM, Porter KR, Murphy GR, Suharyono W, King C-C, Hayes CG, Temenak JJ, 2001. Development and evaluation of serotype- and group-specific flourogenic reverse transcriptase PCR (TaqMan) assays for dengue virus. J Clin Microbiol 39 :4119–4124.
-
36
Bustin SA, 2000. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 25 :169–193.
-
37
SAS Institute, 2004. SAS/STAT® 9.1 User’s Guide. SAS Institute, Cary, NC.
-
38
Scheiner SM, 2001. MANOVA: multiple response variables and multispecies interactions. Scheiner SM, Gurevitch J, eds. Design and Analysis of Ecological Experiments. Second edition. Oxford, UK: Oxford University Press, 99–115.
-
39
Effler PV, Pang L, Kitsutani P, Vorndam V, Nakata M, Ayers T, Elm J, Tom T, Reiter P, Rigau-Perez JG, Hayes JM, Mills K, Napier M, Clark GG, Gubler DJ, 2005. Dengue Fever, Hawaii 2001–2002. Emerg Infect Dis 11 :742–749.
-
40
Almeida AP, Baptista SSSG, Sousa CAGCC, Nova MTLM, Ramos HC, Panella NA, Godsey M, Simões MJ, Anselmo ML, Komar N, Mitchell CJ, Ribeiro H, 2005. Bioecology and vectorial capacity of Aedes albopictus (Diptera: Culicidae) in Macao, China in relation to dengue virus transmission. J Med Entomol 42 :419–428.
-
41
Bosio CF, Beaty BJ, Black WC, 1998. Quantitative genetics of vector competence for dengue-2 virus in Aedes aegypti.Am J Trop Med Hyg 59 :965–970.
-
42
Agudelo-Silva F, Spielman A, 1984. Paradoxical effects of simulated larviciding on production of adult mosquitoes. Am J Trop Med Hyg 33 :1267–1269.
-
43
Wilson ML, Agudelo-Silva F, Spielman A, 1990. Increased abundance, size, and longevity of food-deprived mosquito populations exposed to a fungal larvicide. Am J Trop Med Hyg 43 :551–556.
-
44
Morin PJ, 1981. Predatory salamanders reverse the outcome of competition among three species of anuran tadpoles. Science 212 :1284–1286.
-
45
Chambers RC, 1985. Competition and predation among larvae of three species of treehole breeding mosquitoes. Lounibos LP, Rey JR, Frank JH, eds. Ecology of Mosquitoes: Proceedings of a Workshop. Vero Beach, FL: Florida Medical Entomology Laboratory, 25–53.
-
46
Grill CP, Juliano SA, 1996. Predicting species interactions based on behaviour: predation and competition in container-dwelling mosquitoes. J Anim Ecol 65 :63–76.
-
47
Alto BW, Griswold MW, Lounibos LP, 2005. Habitat complexity and sex-dependent predation of mosquito larvae in containers. Oecologia 146 :300–310.
-
48
Maciel-de-Freitas R, Codeço CT, Lourenço-de-Oliveira R, 2007. Body size-associated survival and dispersal rates of Aedes aegypti in Rio de Janeiro. Med Vet Entomol 21 :284–292.
-
49
Fish D, 1985. An analysis of adult size variation within natural mosquito populations. Lounibos LP, Rey JR, Frank JH, eds. Ecology of Mosquitoes: Proceedings of a Workshop. Vero Beach, FL: Florida Medical Entomology Laboratory, 419–429.
-
50
Schneider JR, Mori A, Romero-Severson J, Chadee DD, Severson DW, 2007. Investigations of dengue-2 susceptibility and body size among Aedes aegypti populations. Med Vet Entomol 21 :370–376.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 202 | 136 | 13 |
| Full Text Views | 344 | 6 | 0 |
| PDF Downloads | 120 | 5 | 0 |