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Filarial/Human Immunodeficiency Virus Coinfection in Urban Southern India

Kawsar R. TalaatLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Y. R. Gaitonde Centre for AIDS Research and Education, Chennai, India; Tuberculosis Research Centre, Indian Council of Medical Research, Chennai, India

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Nagalingeswaran KumarasamyLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Y. R. Gaitonde Centre for AIDS Research and Education, Chennai, India; Tuberculosis Research Centre, Indian Council of Medical Research, Chennai, India

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Soumya SwaminathanLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Y. R. Gaitonde Centre for AIDS Research and Education, Chennai, India; Tuberculosis Research Centre, Indian Council of Medical Research, Chennai, India

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Ramya GopinathLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Y. R. Gaitonde Centre for AIDS Research and Education, Chennai, India; Tuberculosis Research Centre, Indian Council of Medical Research, Chennai, India

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Thomas B. NutmanLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Y. R. Gaitonde Centre for AIDS Research and Education, Chennai, India; Tuberculosis Research Centre, Indian Council of Medical Research, Chennai, India

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The disease course of human immunodeficiency virus (HIV) is often altered by existing or newly acquired coinfections. Treatment or prevention of these concomitant infections often improves the quality and duration of life of HIV-infected persons. The impact of helminth infections on infections with HIV is less clear. However, HIV is frequently most problematic in areas where helminth infections are common. In advance of the widespread distribution of drugs for elimination of lymphatic filariasis, we assessed the prevalence of active Wuchereria bancrofti infection among HIV-positive patients in Chennai, India at two time points separated by four years. We found that the overall prevalence of W. bancrofti infections among HIV-positive persons was 5–9.5%, and there were no quantitative differences in circulating filarial antigen levels between HIV-positive and HIV-negative filarial-infected patients.

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