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Absence of Brain Involvement and Factors Related to Positive Serology in a Prospective Series of 61 Cases with Pulmonary Hydatid Disease

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  • 1 Department of Microbiology, School of Sciences and Clinical Epidemiology Unit, School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru; Cysticercosis Unit, Instituto Nacional de Ciencias Neurológicas Lima, Peru; Division of Thoracic and Cardiovascular Surgery, Hospital Nacional Hipolito Unanue, Lima, Peru; Thoracic and Cardiovascular Surgery Program, Hospital Nacional Dos de Mayo, Lima, Peru; Department of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland
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A prospective series of 65 patients with surgically confirmed lung cystic hydatid disease was evaluated in terms of their radiologic characteristics, serologic response, and presence of cysts in other organs. Cysts were mostly single and located in lower lung lobes. Liver compromise was found in 34% of the patients. Despite a systematic search, no patient showed brain cysts in this series. Twelve patients had previous hydatid disease: six in the liver and eight in the lung (two had involvement of both organs in the past). Serology using bovine cyst fluid in an immunoblot assay was 85% sensitive. Serologic response was not associated with number or cyst or compromise of other organs but was clearly associated to the presence of at least one complicated cyst. Cyst status in terms of complications should be described to allow appropriate assessment of serologic evaluations.

Author Notes

Reprint requests: Hector H. Garcia, Department of Microbiology, Universidad Peruana Cayetano Heredia. Av. H. Delgado 430, SMP, Lima 31, Peru, Tel: 511-3287360, Fax: 511-3284038, E-mail: hgarcia@jhsph.edu.
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