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Pharmacokinetics of Dihydroartemisinin in a Murine Malaria Model

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  • 1 School of Pharmacy, Curtin University of Technology, Bentley, Western Australia; School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia
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Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 L/hr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokinetic–pharmacodynamic evaluations of DHA in murine models.