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-
1
Perez-Perez GI, Salomaa A, Kosunen TU, Daverman B, Rautelin H, Aromaa A, Knekt P, Blaser MJ, 2002. Evidence that cagA(+) Helicobacter pylori strains are disappearing more rapidly than cagA(−) strains. Gut 50 :295–298.
-
2
Falush D, Wirth T, Linz B, Pritchard JK, Stephens M, Kidd M, Blaser MJ, Graham DY, Vacher S, Perez-Perez GI, Yamaoka Y, Mégraud F, Otto K, Reichard U, Katzowitsch E, Wang X, Achtman M, Suerbaum S, 2003. Traces of human migrations in Helicobacter pylori populations. Science 299 :1582–1585.
-
3
Bonatto SL, Salzano FM, 1997. A single and early migration for the peopling of the Americas supported by mitochondrial DNA sequence data. Proc Natl Acad Sci USA 94 :1866–1871.
-
4
Fuselli S, Tarazona-Santos E, Dupanloup I, Soto A, Luiselli D, Pettener D, 2003. Mitochondrial DNA diversity in South America and the genetic history of Andean highlanders. Mol Biol Evol 20 :1682–1691.
-
5
Loureiro CL, Alonso R, Pacheco BA, Uzcátequi MG, Villegas L, León G, De Saéz A, Liprandi F, López JL, Pujol FH, 2002. High prevalence of GB virus C/hepatitis G virus genotype 3 among autochthonous Venezuelan populations. J Med Virol 68 :357–362.
-
6
Blitz-Dorfman L, Monsalve F, Atencio R, Porto L, Monzon M, Favorov MO, Fields HA, Pujol FH, Echevarría JM, 1996. Serological survey of markers of infection with viral hepatitis among the Yukpa Amerindians from western Venezuela. Ann Trop Med Parasitol 90 :655–657.
-
7
Devesa M, Rodríguez C, León G, Liprandi F, Pujol FH, 2004. Clade analysis and surface antigen polymorphism of hepatitis B virus American genotypes. J Med Virol 72 :377–384.
-
8
Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, Stemmermann GM, Nomura A, 1995. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 55 :2111–2115.
-
9
Romero-Gallo J, Perez-Perez GI, Novivk RP, Kamath P, Norbu T, Blaser MJ, 2002. Responses of endoscopy patients in Ladakh, India, to Helicobacter pylori whole-cell and cagA antigens. Clin Diagn Lab Immunol 9 :1313–1317.
-
10
Greenberg JH, Languages in the Americas. Stanford, CA: Stanford University Press, 1987.
-
11
Layrisse M, Wilbert J, The Diego Blood Group System and the Mongoloid Realm. Caracas: Fundación La Salle de Ciencias Naturales ICdAyS, 1999.
-
12
Raj SM, Yap K, Haq JA, Singh S, Hamid A, 2001. Further evidence for an exceptionally low prevalence of Helicobacter pylori infection among peptic ulcer patients in northeastern peninsular Malaysia. Trans R Soc Trop Med Hyg 95 :24–27.
-
13
Huang SSS, Hassan AKR, Choo KE, Ibrahim MI, Davis TME, 2004. Prevalence and predictors of Helicobacter pylori infection in children and adults from the Penan ethnic minority of Malaysian Borneo. Am J Trop Med Hyg 71 :444–450.
-
14
Tokudome S, Soeripto, Triningsih FXE, Ananta I, Sadao S, Koyonori K, Susumu A, Kosaka H, Ishikawa H, Azuma T, Moore MA, 2005. Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia. Cancer Lett 219 :57–61.
-
15
Sousa AO, Salem JI, Lee FK, Verçosa MC, Cruaud P, Bloom BR, Lagrange PH, David HL, 1997. An epidemic of tuberculosis with a high rate of tuberculin anergy among a population previously unexposed to tuberculosis, the Yanomami Indians of the Brazilian Amazon. Proc Natl Acad Sci USA 94 :13227–13232.
-
16
Hook-Nikanne J, Perez-Perez GI, Blaser MJ, 1997. Antigenic characterization of Helicobacter pylori strains from different parts of the world. Clin Diagn Lab Immunol 4 :592–597.
-
17
Aspholm-Hurtig M, Dailide G, Lahmann M, Kalia A, Ilver D, Roche N, Vikström S, Sjöström R, Lindén S, Bäckström A, Lundberg C, Arnqvist A, Mahdavi J, Nilsson UJ, Velapatiño B, Gilman RH, Gerhard M, Alarcon T, López-Brea M, Nakazawa T, Fox JG, Correa P, Dominguez-Bello MG, Perez-Perez GI, Blaser MJ, Normark S, Carlstedt I, Oscarson S, Teneberg S, Berg DE, Borén T, 2004. Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science 305 :519–522.
-
18
Linz B, The Evolutionary History of the CAG Pathogenicity Island From Helicobacter pylori. Sydney, Australia: CHRO, 2005.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 921 | 876 | 23 |
| Full Text Views | 274 | 10 | 0 |
| PDF Downloads | 59 | 9 | 0 |
Helicobacter pylori Seroprevalence in Amerindians from Isolated Locations
Monica Contreras
Monica Contreras
Venezuelan Institute of Scientific Research, Venezuela; Departments of Medicine and Microbiology, New York University School of Medicine, New York; Department of Biology, University of Cagliari, Cagliari, Italy; Ponce Consultores, Caracas, Venezuela; Department of Biology, University of Puerto Rico, San Juan, Puerto Rico
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Flor H. Pujol
Flor H. Pujol
Venezuelan Institute of Scientific Research, Venezuela; Departments of Medicine and Microbiology, New York University School of Medicine, New York; Department of Biology, University of Cagliari, Cagliari, Italy; Ponce Consultores, Caracas, Venezuela; Department of Biology, University of Puerto Rico, San Juan, Puerto Rico
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Guillermo I. Pérez-Pérez
Guillermo I. Pérez-Pérez
Venezuelan Institute of Scientific Research, Venezuela; Departments of Medicine and Microbiology, New York University School of Medicine, New York; Department of Biology, University of Cagliari, Cagliari, Italy; Ponce Consultores, Caracas, Venezuela; Department of Biology, University of Puerto Rico, San Juan, Puerto Rico
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Elisabetta Marini
Elisabetta Marini
Venezuelan Institute of Scientific Research, Venezuela; Departments of Medicine and Microbiology, New York University School of Medicine, New York; Department of Biology, University of Cagliari, Cagliari, Italy; Ponce Consultores, Caracas, Venezuela; Department of Biology, University of Puerto Rico, San Juan, Puerto Rico
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Fabian A. Michelangeli
Fabian A. Michelangeli
Venezuelan Institute of Scientific Research, Venezuela; Departments of Medicine and Microbiology, New York University School of Medicine, New York; Department of Biology, University of Cagliari, Cagliari, Italy; Ponce Consultores, Caracas, Venezuela; Department of Biology, University of Puerto Rico, San Juan, Puerto Rico
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Liliana Ponce
Liliana Ponce
Venezuelan Institute of Scientific Research, Venezuela; Departments of Medicine and Microbiology, New York University School of Medicine, New York; Department of Biology, University of Cagliari, Cagliari, Italy; Ponce Consultores, Caracas, Venezuela; Department of Biology, University of Puerto Rico, San Juan, Puerto Rico
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María G. Domínguez-Bello
María G. Domínguez-Bello
Venezuelan Institute of Scientific Research, Venezuela; Departments of Medicine and Microbiology, New York University School of Medicine, New York; Department of Biology, University of Cagliari, Cagliari, Italy; Ponce Consultores, Caracas, Venezuela; Department of Biology, University of Puerto Rico, San Juan, Puerto Rico
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Helicobacter pylori seems universally distributed in all human populations, with high prevalence in the third world. Because H. pylori is an ancestral indigenous microbe of the human stomach, we hypothesized that its prevalence in isolated Amerindians would be high. A serologic study was performed on 19 Guahibo-Piaroa and 17 Warao in Venezuela, using H. pylori whole cell (WC) and CagA antigens from US strains. For Guahibo-Piaroa Amerindians, CagA seropositivity was 95%, but WC seropositivity was only 74%. For Warao, both CagA and WC seropositive proportions were low (65% and 76%, respectively). Because all CagA-seropositive individuals carry H. pylori, the results suggest that there has been bacterial antigen divergence, probably caused by genetic drift/natural selection, on humans and their microbes in isolated human groups.
Author Notes
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-
1
Perez-Perez GI, Salomaa A, Kosunen TU, Daverman B, Rautelin H, Aromaa A, Knekt P, Blaser MJ, 2002. Evidence that cagA(+) Helicobacter pylori strains are disappearing more rapidly than cagA(−) strains. Gut 50 :295–298.
-
2
Falush D, Wirth T, Linz B, Pritchard JK, Stephens M, Kidd M, Blaser MJ, Graham DY, Vacher S, Perez-Perez GI, Yamaoka Y, Mégraud F, Otto K, Reichard U, Katzowitsch E, Wang X, Achtman M, Suerbaum S, 2003. Traces of human migrations in Helicobacter pylori populations. Science 299 :1582–1585.
-
3
Bonatto SL, Salzano FM, 1997. A single and early migration for the peopling of the Americas supported by mitochondrial DNA sequence data. Proc Natl Acad Sci USA 94 :1866–1871.
-
4
Fuselli S, Tarazona-Santos E, Dupanloup I, Soto A, Luiselli D, Pettener D, 2003. Mitochondrial DNA diversity in South America and the genetic history of Andean highlanders. Mol Biol Evol 20 :1682–1691.
-
5
Loureiro CL, Alonso R, Pacheco BA, Uzcátequi MG, Villegas L, León G, De Saéz A, Liprandi F, López JL, Pujol FH, 2002. High prevalence of GB virus C/hepatitis G virus genotype 3 among autochthonous Venezuelan populations. J Med Virol 68 :357–362.
-
6
Blitz-Dorfman L, Monsalve F, Atencio R, Porto L, Monzon M, Favorov MO, Fields HA, Pujol FH, Echevarría JM, 1996. Serological survey of markers of infection with viral hepatitis among the Yukpa Amerindians from western Venezuela. Ann Trop Med Parasitol 90 :655–657.
-
7
Devesa M, Rodríguez C, León G, Liprandi F, Pujol FH, 2004. Clade analysis and surface antigen polymorphism of hepatitis B virus American genotypes. J Med Virol 72 :377–384.
-
8
Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, Stemmermann GM, Nomura A, 1995. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 55 :2111–2115.
-
9
Romero-Gallo J, Perez-Perez GI, Novivk RP, Kamath P, Norbu T, Blaser MJ, 2002. Responses of endoscopy patients in Ladakh, India, to Helicobacter pylori whole-cell and cagA antigens. Clin Diagn Lab Immunol 9 :1313–1317.
-
10
Greenberg JH, Languages in the Americas. Stanford, CA: Stanford University Press, 1987.
-
11
Layrisse M, Wilbert J, The Diego Blood Group System and the Mongoloid Realm. Caracas: Fundación La Salle de Ciencias Naturales ICdAyS, 1999.
-
12
Raj SM, Yap K, Haq JA, Singh S, Hamid A, 2001. Further evidence for an exceptionally low prevalence of Helicobacter pylori infection among peptic ulcer patients in northeastern peninsular Malaysia. Trans R Soc Trop Med Hyg 95 :24–27.
-
13
Huang SSS, Hassan AKR, Choo KE, Ibrahim MI, Davis TME, 2004. Prevalence and predictors of Helicobacter pylori infection in children and adults from the Penan ethnic minority of Malaysian Borneo. Am J Trop Med Hyg 71 :444–450.
-
14
Tokudome S, Soeripto, Triningsih FXE, Ananta I, Sadao S, Koyonori K, Susumu A, Kosaka H, Ishikawa H, Azuma T, Moore MA, 2005. Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia. Cancer Lett 219 :57–61.
-
15
Sousa AO, Salem JI, Lee FK, Verçosa MC, Cruaud P, Bloom BR, Lagrange PH, David HL, 1997. An epidemic of tuberculosis with a high rate of tuberculin anergy among a population previously unexposed to tuberculosis, the Yanomami Indians of the Brazilian Amazon. Proc Natl Acad Sci USA 94 :13227–13232.
-
16
Hook-Nikanne J, Perez-Perez GI, Blaser MJ, 1997. Antigenic characterization of Helicobacter pylori strains from different parts of the world. Clin Diagn Lab Immunol 4 :592–597.
-
17
Aspholm-Hurtig M, Dailide G, Lahmann M, Kalia A, Ilver D, Roche N, Vikström S, Sjöström R, Lindén S, Bäckström A, Lundberg C, Arnqvist A, Mahdavi J, Nilsson UJ, Velapatiño B, Gilman RH, Gerhard M, Alarcon T, López-Brea M, Nakazawa T, Fox JG, Correa P, Dominguez-Bello MG, Perez-Perez GI, Blaser MJ, Normark S, Carlstedt I, Oscarson S, Teneberg S, Berg DE, Borén T, 2004. Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science 305 :519–522.
-
18
Linz B, The Evolutionary History of the CAG Pathogenicity Island From Helicobacter pylori. Sydney, Australia: CHRO, 2005.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 921 | 876 | 23 |
| Full Text Views | 274 | 10 | 0 |
| PDF Downloads | 59 | 9 | 0 |