• 1

    Chhetri MK, Chakravorty NC, Neelakantan C, Bhattachrya B, Sarkar SK, 1969. Hepatic amoebiasis and its treatment with metronidazole. J Assoc Physicians India 17 :681–688.

    • Search Google Scholar
    • Export Citation
  • 2

    Lamont NM, Pooler NR, 1958. Hepatic amoebiasis: a study of 250 cases. Q J Med 27 :389–395.

  • 3

    Vakil BI, Mehta AJ, Desai HN, 1970. Atypical manifestations of amoebic liver abscess. J Trop Med Hyg 73 :63–74.

  • 4

    Aptekar SI, Sood ID, 1970. Amoebic abscess of the liver. Indian J Surg 32 :169–176.

  • 5

    Dutta DV, Saha S, Samant A, Singh MD, Aikat BK, Chuttani PN, 1973. The clinical pattern and prognosis of patients with amoebic liver abscess. Am J Dig Dis 18 :887–892.

    • Search Google Scholar
    • Export Citation
  • 6

    Joshi VR, Kapoor OP, Purohit AV, Nathani AN, Lele RD, 1972. Jaundice in amoebic liver abscess. J Assoc Physicians India 20 :761–768.

  • 7

    Nigam P, Gupta AK, Kapoor KK, Sharan GR, Goyal BM, Joshi LD, 1985. Cholestasis in amoebic liver abscess. Gut 26 :140–145.

  • 8

    Dutta DV, Chuttani PN, 1971. Cholestasis in patients with amoebic liver abscess. Am J Dig Dis 16 :977–985.

  • 9

    Dutta DV, 1977. Amoebic liver abscess with cholestasis. J Assoc Physicians India 20 :907–912.

  • 10

    Subramanian R, Madangopalan N, 1970. Amoebiasis Monograph. Bombay, India: Sandoz India.

  • 11

    Hazra DK, Seth HC, Elhence GP, 1970. Jaundice in amoebic liver abscess. J Ind Med Assoc 55 :244–250.

  • 12

    Stanley SL Jr, 2003. Amoebiasis. Lancet 361 :1025–1034.

  • 13

    Rajak CL, Gupta S, Jain S, Chawla Y, Gulati M, Suri M, 1998. Percutaneous treatment of liver abscess: needle aspiration versus catheter drainage. AJR 170 :1035–1039.

    • Search Google Scholar
    • Export Citation
  • 14

    Sandblom P, 1987. Hemobilia. In: Way LW, Pellegrini CA, eds. Surgery for the Gallbladder and Bile Ducts. Philadelphia: WB Saunders, 643–654.

  • 15

    Glaser K, Wetscher G, Pointner R, Schwab G, Tschmelitsch J, Gadenstatter M, 1994. Traumatic bilhemia. Surgery 116 :24–27.

  • 16

    Struyven J, Cremer M, Pirson P, Jeanty P, Jeanmart J, 1982. Posttraumatic bilhemia: diagnosis and catheter therapy. AJR Am J Roentgenol 138 :746–747.

    • Search Google Scholar
    • Export Citation
  • 17

    Gable DR, Allen JW, Harrell DJ, Carrillo EH, 1997. Endoscopic treatment of posttraumatic “bilhemia”: case report. J Trauma 43 :534–536.

    • Search Google Scholar
    • Export Citation
  • 18

    Bose SM, Mazumdar A, Singh V, 2000. Non-operative management of gunshot injury of liver causing bilhemia. Aust NZ J Surg 70 :382–384.

  • 19

    Singh V, Narasimhan KL, Verma GR, Singh G, 2007. Endoscopic management of traumatic hepatobiliary injuries. J Gastroenterol Hepatol 22 :1205–1209.

    • Search Google Scholar
    • Export Citation
  • 20

    Spahr L, Sahai A, Lahaie R, Dufresne MP, Bui BT, Dagenais M, Fenyves D, Layrargues P, 1996. Transient healing of TIPS—induced biliovenous fistula by PTFE-covered stent graft. Dig Dis Sci 41 :2229–2232.

    • Search Google Scholar
    • Export Citation
  • 21

    Sears RJ, Ishitani MB, Bickston SJ, 1997. Endoscopic diagnosis and therapy of a case of bilhemia after percutaneous liver biopsy. Gastrointest Endosc 46 :276–279.

    • Search Google Scholar
    • Export Citation
  • 22

    Verhille MS, Munoz SJ, 1991. Acute biliary–vascular fistula following needle aspiration of the liver. Gastroenterology 101 :1731–1733.

    • Search Google Scholar
    • Export Citation
  • 23

    Foutch PG, Harian JR, Hoefer M, 1993. Endoscopic therapy for patients with a postoperative biliary leak. Gastrointest Endosc 39 :416–421.

    • Search Google Scholar
    • Export Citation
  • 24

    Bjorkman DJ, Carr-Locke DL, Lichtenstein DR, 1995. Postsurgical bile leaks: endoscopic obliteration of the transpapillary pressure gradient is enough. Am J Gastroenterol 90 :2128–2133.

    • Search Google Scholar
    • Export Citation
  • 25

    Chow S, Bosco JJ, Heiss FW, Shea JA, Qaseem T, Howell D, 1997. Successful treatment of post cholecystectomy bile leaks using nasobiliary tube drainage and sphincterotomy. Am J Gastroenterol 92 :1839–1843.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 690 317 36
PDF Downloads 386 159 18
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 

 

 

Pathophysiology of Jaundice in Amoebic Liver Abscess

View More View Less
  • 1 Departments of Hepatology, Internal Medicine, and Radiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160 022 India
Restricted access

Jaundice in patients with amoebic liver abscess is a frequent occurrence. However, the pathophysiology of jaundice in these patients is not fully understood. Hepatic necrosis leads to damage to bile ducts as well as various vascular structures, which in turn leads to biliovascular fistula and jaundice. We studied the mechanism of jaundice in patients with amoebic liver abscess. We prospectively evaluated 12 patients with amoebic liver abscess and jaundice from February 2002 to August 2007. All patients underwent various investigations, including imaging studies. There were 11 males and 1 female patient with a mean age of 41.3 years. Mean duration of illness before presentation was 13.8 days. All patients had fever and jaundice. We detected damaged hepatic veins and bile ducts in all patients with amoebic liver abscess causing biliovascular fistula and hyperbilirubinemia, which reverted to normal after biliary diversion with nasobiliary drainage. Jaundice in patients with amoebic liver abscess is caused by biliovascular fistula resulting from hepatic necrosis leading to damage to bile ducts and hepatic veins.

Author Notes

Reprint requests: Virendra Singh, Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, Tel: +91-172-272-4323, Fax: +91-172-274-4401, E-mail: virendrasingh100@hotmail.com.
Save