Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Davis NL, Willis LV, Smith JF, Johnston RE, 1989. In vitro synthesis of infectious Venezuelan equine encephalitis virus RNA from a cDNA clone: analysis of a viable deletion mutant. Virology 171 :189–204.
-
2
Davis NL, Powell N, Greenwald GF, Willis LV, Johnson BJB, Smith JF, Johnston RE, 1991. Attenuating mutations in the E2 glycoprotein gene of Venezuelan equine encephalitis virus: construction of single and multiple mutants in a full-length CDNA clone. Virology 183 :20–31.
-
3
Grieder FB, Nguyen HT, 1996. Virulent and attenuated mutant Venezuelan equine encephalitis virus show marked differences in replication in infection in murine macrophages. Microb Pathog 21 :85–95.
-
4
Davis NL, Brown KW, Greenwald GF, Zajac AJ, Zacny VL, Smith JF, Johnston RE, 1995. Attenuated mutants of Venezuelan equine encephalitis virus containing lethal mutations in the PE2 cleavage signal combined with a second site suppressor mutation in E1. Virology 212 :102–110.
-
5
Pratt WD, Davis NL, Johnston RE, Smith JF, 2003. Genetically engineered, live attenuated vaccines for Venezuelan equine encephalitis: testing in animal models. Vaccine 21 :3854–3862.
-
6
Hart MK, Lind C, Bakken R, Robertson M, Tammariello R, Ludwig GV, 2001. Onset and duration of protective immunity to IA/IB and IE strains of Venezuelan equine encephalitis virus in vaccinated mice. Vaccine 20 :616–622.
-
7
Turell MJ, Ludwig GV, Kondig J, Smith JF, 1999. Limited potential for mosquito transmission of genetically engineered, live-attenuated Venezuelan equine encephalitis virus vaccine candidates. Am J Trop Med Hyg 60 :1041–1044.
-
8
Osorio JE, Godsey MS, DeFoliart GR, Yuill TM, 1996. La Crosse viremias in white-tailed deer and chipmunks exposed by injection or mosquito bite. Am J Trop Med Hyg 54 :338–342.
-
9
Edwards JF, Higgs S, Beaty BJ, 1998. Mosquito feeding-induced enhancement of Cache Valley virus (Bunyaviridae) infection in mice. J Med Entomol 35 :261–265.
-
10
Schneider BS, Soong L, Girard YA, Campbell G, Mason P, Higgs S, 2006. Potentiation of West Nile encephalitis by mosquito feeding. Viral Immunol 19 :74–82.
-
11
Gargan TP II, Bailey CL, Higbee GA, Gad A, El Said S, 1983. The effect of laboratory colonization on the vector-pathogen interactions of Egyptian Culex pipiens and Rift Valley fever virus. Am J Trop Med Hyg 32 :1154–1163.
-
12
Karabatsos N, ed., 1985. International Catalogue of Arboviruses including Certain other Viruses of Vertebrates. Third edition. San Antonio, TX: American Society of Tropical Medicine and Hygiene.
-
13
Turell MJ, Ludwig GV, Beaman JR, 1992. Transmission of Venezuelan equine encephalomyelitis by Aedes sollicitans and Aedes taeniorhynchus (Diptera: Culicidae). J Med Entomol 29 :62–65.
-
14
Rosen L, Gubler D, 1974. The use of mosquitoes to detect and propagate dengue viruses. Am J Trop Med Hyg 23 :1153–1160.
-
15
Smith DR, Carrara AS, Aguilar PV, Weaver SC, 2005. Evaluation of methods to assess transmission potential of Venezuelan equine encephalitis virus by mosquitoes and estimation of mosquito saliva titers. Am J Trop Med Hyg 73 :33–39.
-
16
Earley E, Peralta PH, Johnson KM, 1967. A plaque neutralization method for arboviruses. Proc Soc Exp Biol Med 125 :741–747.
-
17
Styer LM, Bernard KA, Kramer LD, 2006. Enhanced early West Nile virus infection in young chickens infected by mosquito bite: effect of viral dose. Am J Trop Med Hyg 75 :337–345.
-
18
Schneider BS, Soong L, Zeidner NS, Higgs S, 2004. Aedes aegypti salivary gland extracts modulate anti-viral and TH1/TH2 cytokine responses to Sindbis virus infection. Viral Immunol 17 :565–573.
-
19
Limesand KH, Higgs S, Pearson LD, Beaty BJ, 2003. Effect of mosquito salivary gland treatment on vesicular stomatitis New Jersey virus replication and interferon alpha/beta expression in vitro. J Med Entomol 40 :199–205.
-
20
Wanasen N, Nussenzveig RH, Champagne DE, Soong L, Higgs S, 2004. Differential modulation of murine host immune response by salivary gland extracts from the mosquitoes Aedes aegypti and Culex quinquefasciatus. Med Vet Entomol 18 :191–199.
-
21
Kissling RE, Chamberlain RW, Eidson ME, Sikes RK, Bucca MA, 1954. Studies on the North American arthropod-borne encephalitides. II. Eastern equine encephalitis in horses. Am J Hyg 60 :237–250.
-
22
Reisen WK, Chiles RE, Kramer LD, Martinez VM, Eldridge BF, 2000. Method of infection does not alter response of chicks and house finches to western equine encephalomyelitis and St. Louis encephalitis viruses. J Med Entomol 37 :250–258.
-
23
Sbrana E, Tonry JH, Xiao SY, da Rosa AP, Higgs S, Tesh RB, 2005. Oral transmission of West Nile virus in a hamster model. Am J Trop Med Hyg 72 :325–329.
-
24
Smith DR, Aguilar PV, Coffey LL, Gromowski GD, Wang E, Weaver SC, 2006. Venezuelan equine encephalitis virus transmission and effect on pathogenesis. Emerg Infect Dis 12 :1190–1196.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 655 | 609 | 14 |
| Full Text Views | 231 | 11 | 0 |
| PDF Downloads | 50 | 9 | 0 |
Protection of Hamsters by Venezuelan Equine Encephalitis Virus Candidate Vaccine V3526 against Lethal Challenge by Mosquito Bite and Intraperitoneal Injection
Michael J. Turell
Michael J. Turell
Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
Search for other papers by Michael J. Turell in
Current site
Google Scholar
PubMed
Search for other papers by Michael J. Turell in
Current site
Google Scholar
PubMed
Michael D. Parker
Michael D. Parker
Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
Search for other papers by Michael D. Parker in
Current site
Google Scholar
PubMed
Search for other papers by Michael D. Parker in
Current site
Google Scholar
PubMed
In an attempt to improve the current live, attenuated vaccine (TC-83) for Venezuelan equine encephalitis virus (VEEV), specific mutations associated with attenuation of VEEV in rodent models were inserted into a full-length cDNA clone of the Trinidad donkey strain of VEEV by site-directed mutagenesis. Because some viruses have been reported to be more pathogenic when introduced by mosquito bite than the same virus introduced by needle inoculation, there were concerns that the presence of mosquito saliva, or changes in the virus caused by replication in a mosquito, might allow the virus to overcome the protective effects of prior vaccination with V3526. Therefore, we determined if hamsters vaccinated with V3526 were protected from challenge with the virulent Trinidad donkey strain of VEEV. All non-vaccinated hamsters died after intraperitoneal challenge or after being fed on by VEEV-inoculated Aedes taeniorhynchus. In contrast, hamsters vaccinated with V3526 were resistant to intraperitoneal challenge and infection by VEEV-infected Ae. taeniorhynchus. Therefore, the V3526 candidate vaccine elicits protection against VEEV infection by mosquito bite.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Davis NL, Willis LV, Smith JF, Johnston RE, 1989. In vitro synthesis of infectious Venezuelan equine encephalitis virus RNA from a cDNA clone: analysis of a viable deletion mutant. Virology 171 :189–204.
-
2
Davis NL, Powell N, Greenwald GF, Willis LV, Johnson BJB, Smith JF, Johnston RE, 1991. Attenuating mutations in the E2 glycoprotein gene of Venezuelan equine encephalitis virus: construction of single and multiple mutants in a full-length CDNA clone. Virology 183 :20–31.
-
3
Grieder FB, Nguyen HT, 1996. Virulent and attenuated mutant Venezuelan equine encephalitis virus show marked differences in replication in infection in murine macrophages. Microb Pathog 21 :85–95.
-
4
Davis NL, Brown KW, Greenwald GF, Zajac AJ, Zacny VL, Smith JF, Johnston RE, 1995. Attenuated mutants of Venezuelan equine encephalitis virus containing lethal mutations in the PE2 cleavage signal combined with a second site suppressor mutation in E1. Virology 212 :102–110.
-
5
Pratt WD, Davis NL, Johnston RE, Smith JF, 2003. Genetically engineered, live attenuated vaccines for Venezuelan equine encephalitis: testing in animal models. Vaccine 21 :3854–3862.
-
6
Hart MK, Lind C, Bakken R, Robertson M, Tammariello R, Ludwig GV, 2001. Onset and duration of protective immunity to IA/IB and IE strains of Venezuelan equine encephalitis virus in vaccinated mice. Vaccine 20 :616–622.
-
7
Turell MJ, Ludwig GV, Kondig J, Smith JF, 1999. Limited potential for mosquito transmission of genetically engineered, live-attenuated Venezuelan equine encephalitis virus vaccine candidates. Am J Trop Med Hyg 60 :1041–1044.
-
8
Osorio JE, Godsey MS, DeFoliart GR, Yuill TM, 1996. La Crosse viremias in white-tailed deer and chipmunks exposed by injection or mosquito bite. Am J Trop Med Hyg 54 :338–342.
-
9
Edwards JF, Higgs S, Beaty BJ, 1998. Mosquito feeding-induced enhancement of Cache Valley virus (Bunyaviridae) infection in mice. J Med Entomol 35 :261–265.
-
10
Schneider BS, Soong L, Girard YA, Campbell G, Mason P, Higgs S, 2006. Potentiation of West Nile encephalitis by mosquito feeding. Viral Immunol 19 :74–82.
-
11
Gargan TP II, Bailey CL, Higbee GA, Gad A, El Said S, 1983. The effect of laboratory colonization on the vector-pathogen interactions of Egyptian Culex pipiens and Rift Valley fever virus. Am J Trop Med Hyg 32 :1154–1163.
-
12
Karabatsos N, ed., 1985. International Catalogue of Arboviruses including Certain other Viruses of Vertebrates. Third edition. San Antonio, TX: American Society of Tropical Medicine and Hygiene.
-
13
Turell MJ, Ludwig GV, Beaman JR, 1992. Transmission of Venezuelan equine encephalomyelitis by Aedes sollicitans and Aedes taeniorhynchus (Diptera: Culicidae). J Med Entomol 29 :62–65.
-
14
Rosen L, Gubler D, 1974. The use of mosquitoes to detect and propagate dengue viruses. Am J Trop Med Hyg 23 :1153–1160.
-
15
Smith DR, Carrara AS, Aguilar PV, Weaver SC, 2005. Evaluation of methods to assess transmission potential of Venezuelan equine encephalitis virus by mosquitoes and estimation of mosquito saliva titers. Am J Trop Med Hyg 73 :33–39.
-
16
Earley E, Peralta PH, Johnson KM, 1967. A plaque neutralization method for arboviruses. Proc Soc Exp Biol Med 125 :741–747.
-
17
Styer LM, Bernard KA, Kramer LD, 2006. Enhanced early West Nile virus infection in young chickens infected by mosquito bite: effect of viral dose. Am J Trop Med Hyg 75 :337–345.
-
18
Schneider BS, Soong L, Zeidner NS, Higgs S, 2004. Aedes aegypti salivary gland extracts modulate anti-viral and TH1/TH2 cytokine responses to Sindbis virus infection. Viral Immunol 17 :565–573.
-
19
Limesand KH, Higgs S, Pearson LD, Beaty BJ, 2003. Effect of mosquito salivary gland treatment on vesicular stomatitis New Jersey virus replication and interferon alpha/beta expression in vitro. J Med Entomol 40 :199–205.
-
20
Wanasen N, Nussenzveig RH, Champagne DE, Soong L, Higgs S, 2004. Differential modulation of murine host immune response by salivary gland extracts from the mosquitoes Aedes aegypti and Culex quinquefasciatus. Med Vet Entomol 18 :191–199.
-
21
Kissling RE, Chamberlain RW, Eidson ME, Sikes RK, Bucca MA, 1954. Studies on the North American arthropod-borne encephalitides. II. Eastern equine encephalitis in horses. Am J Hyg 60 :237–250.
-
22
Reisen WK, Chiles RE, Kramer LD, Martinez VM, Eldridge BF, 2000. Method of infection does not alter response of chicks and house finches to western equine encephalomyelitis and St. Louis encephalitis viruses. J Med Entomol 37 :250–258.
-
23
Sbrana E, Tonry JH, Xiao SY, da Rosa AP, Higgs S, Tesh RB, 2005. Oral transmission of West Nile virus in a hamster model. Am J Trop Med Hyg 72 :325–329.
-
24
Smith DR, Aguilar PV, Coffey LL, Gromowski GD, Wang E, Weaver SC, 2006. Venezuelan equine encephalitis virus transmission and effect on pathogenesis. Emerg Infect Dis 12 :1190–1196.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 655 | 609 | 14 |
| Full Text Views | 231 | 11 | 0 |
| PDF Downloads | 50 | 9 | 0 |