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1
Hill AV, 1998. The immunogenetics of human infectious diseases. Annu Rev Immunol 16 :593ā617.
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2
Hill AVS, Allsopp CEM, Kwiatkowki D, Anstey NM, Twumasi P, Rowe PA, Bennett S, Brewster D, McMichael A, Greenwood BM, 1991. Common West African HLA antigens are associated with protection from severe malaria. Nature 352 :595ā600.
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3
May J, Meyer CG, Kun JF, Lell B, Luckner D, Dippmann AK, Bienzle U, Kremsner PG, 1999. HLA class II factors associated with Plasmodium falciparum merozoite surface antigen allele families. J Infect Dis 179 :1042ā1045.
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4
May J, Lell B, Luty AJ, Meyer CG, Kremsner PG, 2001. HLA-DQB1*0501-restricted Th1 type immune responses to Plasmodium falciparum liver stage antigen 1 protect against malaria anemia and reinfections. J Infect Dis 183 :168ā172.
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5
Hill AVS, Elvin J, Willis AC, Aidoo M, Allsopp CE, Gotch FM, Gao XM, Takiguchi M, Greenwood BM, Townsend AR, Mc-Michael AJ, Whittle HC, 1992. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360 :434ā439.
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6
Appawu M, Owusu-Agyei S, Dadzie S, Asoala V, Anto F, Koram K, Rogers WO, Nkrumah FK, Hoffman SL, Fryauff DJ, 2003. Malaria transmission dynamics at a site in northern Ghana proposed for testing malaria vaccines. Trop Med Int Health.
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7
Baird JK, Owusu AS, Utz GC, Koram K, Barcus MJ, Jones TR, Fryauff DJ, Binka FN, Hoffman SL, Nkrumah FN, 2002. Seasonal malaria attack rates in infants and young children in northern Ghana. Am J Trop Med Hyg 66 :280ā286.
-
8
Koram KA, Owusu-Agyei S, Utz G, Binka FN, Baird JK, Hoffman SL, Nkrumah FK, 2000. Severe anemia in young children after high and low malaria transmission seasons in the Kassena-Nankana district of northern Ghana. Am J Trop Med Hyg 62 :670ā674.
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9
Koram KA, Owusu-Agyei S, Fryauff DJ, Anto F, Atuguba F, Hodgson A, Hoffman SL, Nkrumah FK, 2003. Seasonal profiles of malaria infection, anaemia, and bednet use among age groups and communities in northern Ghana. Trop Med Int Health 8 :793ā802.
-
10
Owusu-Agyei S, Koram KA, Baird JK, Utz GC, Binka FN, Nkrumah FK, Fryauff DJ, Hoffman SL, 2001. Incidence of symptomatic and asymptomatic Plasmodium falciparum infection following curative therapy in adult residents of northern Ghana. Am J Trop Med Hyg 65 :197ā203.
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11
Owusu-Agyei S, Fryauff DJ, Chandramohan D, Koram KA, Binka FN, Nkrumah FK, Utz GC, Hoffman SL, 2002. Characteristics of severe anemia and its association with malaria in young children of the Kassena-Nankana District of northern Ghana. Am J Trop Med Hyg 67 :371ā377.
-
12
Kain KC, Lanar DE, 1991. Determination of genetic variation within Plasmodium falciparum by using enzymatically amplified DNA from filter paper disks impregnated with whole blood. J Clin Microbiol 29 :1171ā1174.
-
13
Modiano D, Luoni G, Sirima BS, Lanfrancotti A, Petrarca V, Cruciani F, Simpore J, Ciminelli BM, Foglietta E, Grisanti P, Bianco I, Modiano G, Coluzzi M, 2001. The lower susceptibility to Plasmodium falciparum malaria of Fulani of Burkina Faso (west Africa) is associated with low frequencies of classic malaria-resistance genes. Trans R Soc Trop Med Hyg 95 :149ā152.
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14
Modiano D, Petrarca V, Sirima BS, Nebie I, Diallo D, Esposito F, Coluzzi M, 1996. Different response to Plasmodium falciparum malaria in west African sympatric ethnic groups. Proc Natl Acad Sci USA 93 :13206ā13211.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 23 | 23 | 7 |
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HLA-DRB1*04 Allele Is Associated with Severe Malaria in Northern Ghana
Awo D. Osafo-Addo
Awo D. Osafo-Addo
Noguchi Memorial Institute for Medical Research, Accra, Ghana; Navrongo Health Research Center, Navrongo, Ghana; Naval Medical Research Unit Three, Cairo, Egypt
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Kwadwo A. Koram
Kwadwo A. Koram
Noguchi Memorial Institute for Medical Research, Accra, Ghana; Navrongo Health Research Center, Navrongo, Ghana; Naval Medical Research Unit Three, Cairo, Egypt
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Abraham R. Oduro
Abraham R. Oduro
Noguchi Memorial Institute for Medical Research, Accra, Ghana; Navrongo Health Research Center, Navrongo, Ghana; Naval Medical Research Unit Three, Cairo, Egypt
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Michael Wilson
Michael Wilson
Noguchi Memorial Institute for Medical Research, Accra, Ghana; Navrongo Health Research Center, Navrongo, Ghana; Naval Medical Research Unit Three, Cairo, Egypt
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Abraham Hodgson
Abraham Hodgson
Noguchi Memorial Institute for Medical Research, Accra, Ghana; Navrongo Health Research Center, Navrongo, Ghana; Naval Medical Research Unit Three, Cairo, Egypt
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William O. Rogers
William O. Rogers
Noguchi Memorial Institute for Medical Research, Accra, Ghana; Navrongo Health Research Center, Navrongo, Ghana; Naval Medical Research Unit Three, Cairo, Egypt
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Several associations between specific HLA alleles and susceptibility or resistance to Plasmodium falciparum malaria have been previously reported, but no associations have been confirmed in multiple populations. We studied associations between HLA-A, -B, and DRB1 alleles and severe malaria in northern Ghana. We analyzed HLA-DRB1*04 in 4,032 subjects from a severe malaria case-control study, 790 severe malaria cases, 1,611 mild malaria controls, and 1631 asymptomatic controls. The presence of HLA-DRB1*04 was associated with severe malaria (OR = 2.42, 95% CI = 1.64, 3.58). The allele frequency of DRB1*04 was similar in the two major ethnic groups in the study population, Kassem (4.4%) and Nankam (4.7%), and the OR for the association between DRB1*04 and severe malaria was similar in both ethnic groups. These findings are consistent with results from Gabon suggesting that DRB1*04 is a risk factor for severe malaria.
ProCite
RefWorks
Reference Manager
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-
1
Hill AV, 1998. The immunogenetics of human infectious diseases. Annu Rev Immunol 16 :593ā617.
-
2
Hill AVS, Allsopp CEM, Kwiatkowki D, Anstey NM, Twumasi P, Rowe PA, Bennett S, Brewster D, McMichael A, Greenwood BM, 1991. Common West African HLA antigens are associated with protection from severe malaria. Nature 352 :595ā600.
-
3
May J, Meyer CG, Kun JF, Lell B, Luckner D, Dippmann AK, Bienzle U, Kremsner PG, 1999. HLA class II factors associated with Plasmodium falciparum merozoite surface antigen allele families. J Infect Dis 179 :1042ā1045.
-
4
May J, Lell B, Luty AJ, Meyer CG, Kremsner PG, 2001. HLA-DQB1*0501-restricted Th1 type immune responses to Plasmodium falciparum liver stage antigen 1 protect against malaria anemia and reinfections. J Infect Dis 183 :168ā172.
-
5
Hill AVS, Elvin J, Willis AC, Aidoo M, Allsopp CE, Gotch FM, Gao XM, Takiguchi M, Greenwood BM, Townsend AR, Mc-Michael AJ, Whittle HC, 1992. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360 :434ā439.
-
6
Appawu M, Owusu-Agyei S, Dadzie S, Asoala V, Anto F, Koram K, Rogers WO, Nkrumah FK, Hoffman SL, Fryauff DJ, 2003. Malaria transmission dynamics at a site in northern Ghana proposed for testing malaria vaccines. Trop Med Int Health.
-
7
Baird JK, Owusu AS, Utz GC, Koram K, Barcus MJ, Jones TR, Fryauff DJ, Binka FN, Hoffman SL, Nkrumah FN, 2002. Seasonal malaria attack rates in infants and young children in northern Ghana. Am J Trop Med Hyg 66 :280ā286.
-
8
Koram KA, Owusu-Agyei S, Utz G, Binka FN, Baird JK, Hoffman SL, Nkrumah FK, 2000. Severe anemia in young children after high and low malaria transmission seasons in the Kassena-Nankana district of northern Ghana. Am J Trop Med Hyg 62 :670ā674.
-
9
Koram KA, Owusu-Agyei S, Fryauff DJ, Anto F, Atuguba F, Hodgson A, Hoffman SL, Nkrumah FK, 2003. Seasonal profiles of malaria infection, anaemia, and bednet use among age groups and communities in northern Ghana. Trop Med Int Health 8 :793ā802.
-
10
Owusu-Agyei S, Koram KA, Baird JK, Utz GC, Binka FN, Nkrumah FK, Fryauff DJ, Hoffman SL, 2001. Incidence of symptomatic and asymptomatic Plasmodium falciparum infection following curative therapy in adult residents of northern Ghana. Am J Trop Med Hyg 65 :197ā203.
-
11
Owusu-Agyei S, Fryauff DJ, Chandramohan D, Koram KA, Binka FN, Nkrumah FK, Utz GC, Hoffman SL, 2002. Characteristics of severe anemia and its association with malaria in young children of the Kassena-Nankana District of northern Ghana. Am J Trop Med Hyg 67 :371ā377.
-
12
Kain KC, Lanar DE, 1991. Determination of genetic variation within Plasmodium falciparum by using enzymatically amplified DNA from filter paper disks impregnated with whole blood. J Clin Microbiol 29 :1171ā1174.
-
13
Modiano D, Luoni G, Sirima BS, Lanfrancotti A, Petrarca V, Cruciani F, Simpore J, Ciminelli BM, Foglietta E, Grisanti P, Bianco I, Modiano G, Coluzzi M, 2001. The lower susceptibility to Plasmodium falciparum malaria of Fulani of Burkina Faso (west Africa) is associated with low frequencies of classic malaria-resistance genes. Trans R Soc Trop Med Hyg 95 :149ā152.
-
14
Modiano D, Petrarca V, Sirima BS, Nebie I, Diallo D, Esposito F, Coluzzi M, 1996. Different response to Plasmodium falciparum malaria in west African sympatric ethnic groups. Proc Natl Acad Sci USA 93 :13206ā13211.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 23 | 23 | 7 |
| Full Text Views | 315 | 99 | 0 |
| PDF Downloads | 40 | 9 | 0 |