Toxoplasma gondii and Toxocara spp. Co-infection

Jeffrey L. Jones Division of Parasitic Diseases, National Center for Zoonotic, Vectorborne, and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Division of Health and Nutrition Examination Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland

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Deanna Kruszon-Moran Division of Parasitic Diseases, National Center for Zoonotic, Vectorborne, and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Division of Health and Nutrition Examination Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland

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Kimberly Won Division of Parasitic Diseases, National Center for Zoonotic, Vectorborne, and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Division of Health and Nutrition Examination Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland

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Marianna Wilson Division of Parasitic Diseases, National Center for Zoonotic, Vectorborne, and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Division of Health and Nutrition Examination Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland

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Peter M. Schantz Division of Parasitic Diseases, National Center for Zoonotic, Vectorborne, and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Division of Health and Nutrition Examination Statistics, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland

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DOI:
https://doi.org/10.4269/ajtmh.2008.78.35
Volume/Issue:
Volume 78: Issue 1
Page(s):
35–39
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Toxoplasma gondii and Toxocara spp. infections can cause systemic and ocular disease. To estimate the prevalence of infection with these organisms, we tested serum samples from persons ≥ 12 years of age obtained in the Third National Health and Nutrition Examination Survey (1988–1994). Among those tested for both T. gondii and Toxocara spp. (n = 16,646), the age-adjusted T. gondii antibody prevalence was 23.6% (95% confidence limit [CL] = 22.1–25.1%) and the Toxocara spp. antibody prevalence was 14.0% (95% CL = 12.7–15.4%). Multivariate analysis controlling demographic and risk factors showed that persons infected with Toxocara spp. were more likely to be infected with T. gondii (odds ratio [OR] = 1.93, 95% CL = 1.61–2.31), and similarly, persons infected with T. gondii were more likely to be infected with Toxocara spp. (OR = 1.91, 95% CL = 1.59–2.28). Infection with T. gondii and Toxocara spp. are common and can be prevented by many similar interventions.

Copyright:
Copyright 2008 The American Society of Tropical Medicine 2008
Received:
13 Sep 2007
|
Accepted:
04 Oct 2007
|
Published Online:
Jan 2008
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
  • 1

    Dubey JP, 1986. Toxoplasmosis in cats. Feline Pract 16 :12–45.

  • 2

    Dubey JP, 1998. Toxoplasma gondii oocyst survival under defined temperatures. J Parasitol 84 :862–865.

  • 3

    Frenkel JK, Ruiz A, Chinchilla M, 1975. Soil survival of Toxoplasma oocysts in Kansas and Costa Rica. Am J Trop Med Hyg 24 :439–443.

  • 4

    Dubey JP, 1994. Toxoplasmosis. J Am Vet Med Assoc 205 :1593–1598.

  • 5

    Holland GM, 2003. Ocular toxoplasmosis: a global reassessment, part 1: epidemiology and course of disease. Am J Ophthalmol 136 :973–988.

    • Search Google Scholar
    • Export Citation
  • 6

    Glickman LT, Schantz PM, 1981. Epidemiology and pathogenesis of zoonotic toxocariasis. Epidemiol Rev 3 :230–250.

  • 7

    Beaver PC, Snyder CH, Carrera GM, Dent JH, Lafferty JW, 1952. Chronic eosinophilia due to visceral larva migrans; report of three cases. Pediatrics 9 :7–19.

    • Search Google Scholar
    • Export Citation
  • 8

    Wilder HC, 1950. Nematode endophthalmitis. Trans Am Acad Ophthalmol Otolaryngol 55 :99–109.

  • 9

    National Center for Health Statistics, 1992. Sample Design: Third National Health and Nutrition Examination Survey, 1988–1994. Vital and Health Statistics, Series 2, No. 113. Washington, DC: US GPO (DHHS publication no. PHS 92-1387).

  • 10

    Jones JL, Kruszon-Moran D, Wilson M, McQuillan G, Navin T, McAuley JB, 2001. Toxoplasma gondii infection in the United States: seroprevalence and risk factors. Am J Epidemiol 154 :357–365.

    • Search Google Scholar
    • Export Citation
  • 11

    Glickman L, Schantz P, Greive R, 1986. Toxocariasis. Walls K, Schantz P, eds. Immunodiagnosis of Parasitic Diseases. Volume 1. New York: Academic Press, 201–231.

  • 12

    Ezzati T, Khare M, 1993. Nonresponse adjustment in a national health survey. 1992 Proceedings of the Section on Survey Research Methods. Alexandria, VA: American Statistical Association, 339–344.

  • 13

    Mohadjer LM, Waksberg J, 1996. National Health and Nutrition Examination Survey III: Weighting and Estimation Methodology. Hyattsville, MD: National Center for Health Statistics.

  • 14

    Shah BV, Barnwell BG, Hurt PN, LaVange LM, 1996. SUDAAN User’s Manual, Release 5.50. Research Triangle Park, NC: Research Triangle Institute.

  • 15

    Childs JE, 1985. The prevalence of Toxocara species ova in backyards and gardens of Baltimore, Maryland. Am J Public Health 75 :1092–1094.

    • Search Google Scholar
    • Export Citation
  • 16

    Paul AJ, Todd KS Jr, DiPietro JA, 1988. Environmental contamination by eggs of Toxocara species. Vet Parasitol 26 :339–342.

  • 17

    Weigel RM, Dubey JP, Dyer D, Siegel AM, 1999. Risk factors for infection with Toxoplasma gondii for residents and workers on swine farms in Illinois. Am J Trop Med Hyg 60 :793–798.

    • Search Google Scholar
    • Export Citation
  • 18

    Cook AJ, Gilbert RE, Buffolano W, 2000. Sources of Toxoplasma infection in pregnant women: European multicentre case-control study. European Research Network on Congenital Toxoplasmosis. BMJ 321 :142–147.

    • Search Google Scholar
    • Export Citation
  • 19

    Baril L, Ancelle T, Goulet V, Thulliez P, Tirard-Fleury V, Carme B, 1999. Risk factors for Toxoplasma infection in pregnancy: a case-control study in France. Scand J Infect Dis 31 :305–309.

    • Search Google Scholar
    • Export Citation
  • 20

    Remington JS, McLeod R, Thulliez P, Desmonts G, 2006. Toxoplasmosis. Remington JS, Klein JD, eds. Infectious Diseases of the Fetus and Newborn Infant. Sixth edition. Philadelphia: Elsevier Saunders, 947–1091.

  • 21

    Smith HV, 1993. Antibody reactivity in human toxocariasis. Lewis J, Maizels RM, eds. Toxocara and Toxocariasis: Clinical, Epidemiological, and Molecular Perspectives. London: British Society for Parasitology/Institute of Biology, 91–109.

  • 22

    Dubey JP, Hill DE, Jones JL, Hightower AW, Kirkland E, Roberts JM, Marcet PL, Lehmann T, Vianna MC, Miska K, Sreekumar C, Kwok OC, Shen SK, Gamble HR, 2005. Prevalence of viable Toxoplasma gondii in beef, chicken and pork from retail meat stores in the United States: risk assessment to consumers. J Parasitol 91 :1082–1093.

    • Search Google Scholar
    • Export Citation
  • 23

    Yamasaki H, Araki K, Lim PK, Zasmy N, Mak JW, Taib R, Aoki T, 2000. Development of a highly specific recombinant Toxocara canis second-stage larva excretory-secretory antigen for immunodiagnosis of human toxocariasis. J Clin Microbiol 38 :1409–1413.

    • Search Google Scholar
    • Export Citation
  • 24

    Coelho RAL, Carvalho LB Jr, Perez EP, Araki K, Takeuchi T, Ito A, Aoki T, Yamasaki H, 2005. Prevalence of toxocariasis in northeastern Brazil based on serology using recombinant Toxocara canis antigen. Am J Trop Med Hyg 72 :103–107.

    • Search Google Scholar
    • Export Citation
  • 25

    Frenkel JK, Dubey JP, 1972. Toxoplasmosis and its prevention in cats and man. J Infect Dis 126 :664–673.

  • 26

    U.S. Census Bureau, 2001. Hispanic Population Census Brief, May 2001. Washington, DC: U.S. Census Bureau.

  • 27

    American Pet Products Manufacturers Association National Pet Owners Survey 2005–2006. American Pet Products Manufacturers Association, Inc. Accessed September 12, 2007. Available from http://www.appma.org/press_releasedetail.asp?id=52

  • 28

    Centers for Disease Control and Prevention, 2000. CDC recommendations regarding selected conditions affecting women’s health. MMWR Morb Mortal Wkly Rep 49 :57–75.

    • Search Google Scholar
    • Export Citation
  • 29

    Guidelines for Veterinarians, Prevention of Zoonotic Transmission of Ascarids and Hookworms of Dogs and Cats. Centers for Disease Control and Prevention/American Association of Veterinary Practitioners. Accessed September 12, 2007. Available from http://www.cdc.gov/ncidod/dpd/parasites/ascaris/prevention.htm

  • 30

    Companion Animal Parasite Counsel, Controlling Internal and External Parasites in Dogs and Cats. Accessed September 12, 2007. Available from http://www.capcvet.org/

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