Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Monath TP, 2004. Yellow fever vaccine. Plotkin SA, Orenstein WA, eds. Vaccines. Fourth edition. Philadelphia: Elsevier, 1095–1176.
-
2
Barwick RS, Marfin AA, Cetron MS, 2004. Yellow fever vaccine-associated disease. Scheld WN, Murray BE, Hughes JM, eds. Emerging Infections 6. Washington: ASM Press, 25–34.
-
3
Barnett ED, 2007. Yellow fever: epidemiology and prevention. Clin Infect Dis 44 :850–856.
-
4
Kengsakul K, Sathirapongsasuti K, Punyagupta S, 2002. Fatal myeloencephalitis following yellow fever vaccination in a case with HIV infection. J Med Assoc Thai 85 :131–134.
-
5
Centers for Disease Control and Prevention, 2002. Yellow fever vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). Morb Mortal Wkly Rep 51: 1–11.
-
6
Ahmed AR, Hombal SM, 1984. Cyclophosphamide (Cytoxan*). J Am Acad Dermatol 11 :1115–1126.
-
7
Mateo R, Xiao S-Y, Guzman H, Travasssos da Rosa APA, Tesh RB, 2006. Effects of immunosuppression on West Nile virus infection in hamsters. Am J Trop Med Hyg 75 :356–362.
-
8
Tesh RB, Guzman H, Travassos da Rosa APA, Vasconcelos PFC, Dias LB, Bunnell JE, Zhang H, Xiao SY, 2001. Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus). I. Virologic, biochemical, and immunologic studies. J Infect Dis 183 :1431–1436.
-
9
Tesh RB, 1979. A method for the isolation of dengue viruses, using mosquito cell cultures. Am J Trop Med Hyg 28 :1053–1059.
-
10
Clarke DH, Casals J, 1958. Techniques for hemagglutination and hemagglutination-inhibition of arthropod-borne viruses. Am J Trop Med Hyg 74 :1084–1089.
-
11
Xiao SY, Zhang H, Guzman H, Tesh RB, 2001. Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus). II. Pathology. J Infect Dis 183 :1437–1444.
-
12
Xiao SY, Guzman H, Zhang H, Travassos da Rosa APA, Tesh RB, 2001. West Nile virus infection in the golden hamster (Mesocricetus auratus): a model for West Nile encephalitis. Emerg Infect Dis 7 :714–721.
-
13
McArthur MA, Suderman MT, Mutebi JP, Xiao SY, Barrett ADT, 2003. Molecular characterization of a hamster viscerotropic strain of yellow fever virus. J Virol 77 :1462–1468.
-
14
McArthur MA, Xiao SY, Barrett ADT, 2005. Phenotypic and molecular characterization of non-lethal, hamster-viscerotropic strain of yellow fever virus. Virus Res 110 :65–71.
-
15
Bugher JC, 1951. The pathology of yellow fever. Strode GK, ed. Yellow Fever. New York: McGraw-Hill, 137–164.
-
16
del Rio C, Meier FA, 1998. Yellow fever. Nelson AM, Horsburgh, Jr, eds. Pathology of Emerging Infections 2. Washington: ASM Press, 13–42.
-
17
Sbrana E, Xiao S-Y, Popov VL, Newman PC, Tesh RB, 2006. Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus) III. Clinical laboratory values. Am J Trop Med Hyg 74 :1084–1089.
-
18
Sbrana E, Xiao SY, Guzman H, Ye M, Travassos da Rosa APA, Tesh RB, 2004. Efficacy of post-exposure treatment of yellow fever with ribavirin in a hamster model of the disease. Am J Trop Med Hyg 71 :306–312.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 12 | 12 | 3 |
| Full Text Views | 112 | 77 | 0 |
| PDF Downloads | 21 | 12 | 0 |
Yellow Fever 17-D Vaccine Is Neurotropic and Produces Encephalitis in Immunosuppressed Hamsters
Rosa I. Mateo
Rosa I. Mateo
Departments of Pathology and Internal Medicine and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas
Search for other papers by Rosa I. Mateo in
Current site
Google Scholar
PubMed
Search for other papers by Rosa I. Mateo in
Current site
Google Scholar
PubMed
Shu-Yuan Xiao
Shu-Yuan Xiao
Departments of Pathology and Internal Medicine and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas
Search for other papers by Shu-Yuan Xiao in
Current site
Google Scholar
PubMed
Search for other papers by Shu-Yuan Xiao in
Current site
Google Scholar
PubMed
Amelia P. A. Travassos da Rosa
Amelia P. A. Travassos da Rosa
Departments of Pathology and Internal Medicine and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas
Search for other papers by Amelia P. A. Travassos da Rosa in
Current site
Google Scholar
PubMed
Search for other papers by Amelia P. A. Travassos da Rosa in
Current site
Google Scholar
PubMed
Hao Lei
Hao Lei
Departments of Pathology and Internal Medicine and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas
Search for other papers by Hao Lei in
Current site
Google Scholar
PubMed
Search for other papers by Hao Lei in
Current site
Google Scholar
PubMed
Hilda Guzman
Hilda Guzman
Departments of Pathology and Internal Medicine and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas
Search for other papers by Hilda Guzman in
Current site
Google Scholar
PubMed
Search for other papers by Hilda Guzman in
Current site
Google Scholar
PubMed
Liang Lu
Liang Lu
Departments of Pathology and Internal Medicine and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas
Search for other papers by Liang Lu in
Current site
Google Scholar
PubMed
Search for other papers by Liang Lu in
Current site
Google Scholar
PubMed
Robert B. Tesh
Robert B. Tesh
Departments of Pathology and Internal Medicine and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas
Search for other papers by Robert B. Tesh in
Current site
Google Scholar
PubMed
Search for other papers by Robert B. Tesh in
Current site
Google Scholar
PubMed
Immunosuppressed (cyclophosphamide) adult golden hamsters inoculated intraperitoneally (IP) with wild-type Asibi yellow fever virus (YFV) developed a rapidly fatal illness. Histopathologic and immunohistochemical studies of tissues from these animals showed typical hepatic changes of severe yellow fever (inflammation, hepatocyte necrosis, and steatosis) without brain involvement. In contrast, 50% of immunosuppressed hamsters receiving the YFV-17D–attenuated vaccine developed a slowly progressive encephalitic-type illness. Brain tissue from these latter animals revealed focal neuronal changes, inflammation, and YFV antigen–positive neurons; however, the liver and spleen appeared normal. YFV was isolated from brain cultures of many of these animals. Immunocompetent (non-immunosuppressed) hamsters inoculated with both viruses developed a subclinical infection. Results of this study indicate that wild-type YFV is hepatotropic in immunosuppressed hamsters, whereas the attenuated YFV-17 is primarily neurotropic. These findings support current recommendations against yellow fever vaccination of immunosuppressed/ immunocompromised people and suggest that this hamster model might be useful for monitoring the safety of other live-attenuated YFV vaccines.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Monath TP, 2004. Yellow fever vaccine. Plotkin SA, Orenstein WA, eds. Vaccines. Fourth edition. Philadelphia: Elsevier, 1095–1176.
-
2
Barwick RS, Marfin AA, Cetron MS, 2004. Yellow fever vaccine-associated disease. Scheld WN, Murray BE, Hughes JM, eds. Emerging Infections 6. Washington: ASM Press, 25–34.
-
3
Barnett ED, 2007. Yellow fever: epidemiology and prevention. Clin Infect Dis 44 :850–856.
-
4
Kengsakul K, Sathirapongsasuti K, Punyagupta S, 2002. Fatal myeloencephalitis following yellow fever vaccination in a case with HIV infection. J Med Assoc Thai 85 :131–134.
-
5
Centers for Disease Control and Prevention, 2002. Yellow fever vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). Morb Mortal Wkly Rep 51: 1–11.
-
6
Ahmed AR, Hombal SM, 1984. Cyclophosphamide (Cytoxan*). J Am Acad Dermatol 11 :1115–1126.
-
7
Mateo R, Xiao S-Y, Guzman H, Travasssos da Rosa APA, Tesh RB, 2006. Effects of immunosuppression on West Nile virus infection in hamsters. Am J Trop Med Hyg 75 :356–362.
-
8
Tesh RB, Guzman H, Travassos da Rosa APA, Vasconcelos PFC, Dias LB, Bunnell JE, Zhang H, Xiao SY, 2001. Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus). I. Virologic, biochemical, and immunologic studies. J Infect Dis 183 :1431–1436.
-
9
Tesh RB, 1979. A method for the isolation of dengue viruses, using mosquito cell cultures. Am J Trop Med Hyg 28 :1053–1059.
-
10
Clarke DH, Casals J, 1958. Techniques for hemagglutination and hemagglutination-inhibition of arthropod-borne viruses. Am J Trop Med Hyg 74 :1084–1089.
-
11
Xiao SY, Zhang H, Guzman H, Tesh RB, 2001. Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus). II. Pathology. J Infect Dis 183 :1437–1444.
-
12
Xiao SY, Guzman H, Zhang H, Travassos da Rosa APA, Tesh RB, 2001. West Nile virus infection in the golden hamster (Mesocricetus auratus): a model for West Nile encephalitis. Emerg Infect Dis 7 :714–721.
-
13
McArthur MA, Suderman MT, Mutebi JP, Xiao SY, Barrett ADT, 2003. Molecular characterization of a hamster viscerotropic strain of yellow fever virus. J Virol 77 :1462–1468.
-
14
McArthur MA, Xiao SY, Barrett ADT, 2005. Phenotypic and molecular characterization of non-lethal, hamster-viscerotropic strain of yellow fever virus. Virus Res 110 :65–71.
-
15
Bugher JC, 1951. The pathology of yellow fever. Strode GK, ed. Yellow Fever. New York: McGraw-Hill, 137–164.
-
16
del Rio C, Meier FA, 1998. Yellow fever. Nelson AM, Horsburgh, Jr, eds. Pathology of Emerging Infections 2. Washington: ASM Press, 13–42.
-
17
Sbrana E, Xiao S-Y, Popov VL, Newman PC, Tesh RB, 2006. Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus) III. Clinical laboratory values. Am J Trop Med Hyg 74 :1084–1089.
-
18
Sbrana E, Xiao SY, Guzman H, Ye M, Travassos da Rosa APA, Tesh RB, 2004. Efficacy of post-exposure treatment of yellow fever with ribavirin in a hamster model of the disease. Am J Trop Med Hyg 71 :306–312.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 12 | 12 | 3 |
| Full Text Views | 112 | 77 | 0 |
| PDF Downloads | 21 | 12 | 0 |