Cluster of Cases of Hantavirus Pulmonary Syndrome in Alberta, Canada

Duncan Webster Division of Infectious Diseases, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pediatrics, University of Alberta, Alberta, Canada; Provincial Laboratory for Public Health, Edmonton, Alberta, Canada; Division of Infectious Diseases, University of Alberta, Alberta, Canada; First Nations and Inuit Health Branch, Alberta Region, Alberta, Canada; Alberta Health and Wellness, Alberta, Canada; National Microbiology Laboratory, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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Bonita Lee Division of Infectious Diseases, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pediatrics, University of Alberta, Alberta, Canada; Provincial Laboratory for Public Health, Edmonton, Alberta, Canada; Division of Infectious Diseases, University of Alberta, Alberta, Canada; First Nations and Inuit Health Branch, Alberta Region, Alberta, Canada; Alberta Health and Wellness, Alberta, Canada; National Microbiology Laboratory, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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Ari Joffe Division of Infectious Diseases, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pediatrics, University of Alberta, Alberta, Canada; Provincial Laboratory for Public Health, Edmonton, Alberta, Canada; Division of Infectious Diseases, University of Alberta, Alberta, Canada; First Nations and Inuit Health Branch, Alberta Region, Alberta, Canada; Alberta Health and Wellness, Alberta, Canada; National Microbiology Laboratory, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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Wendy Sligl Division of Infectious Diseases, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pediatrics, University of Alberta, Alberta, Canada; Provincial Laboratory for Public Health, Edmonton, Alberta, Canada; Division of Infectious Diseases, University of Alberta, Alberta, Canada; First Nations and Inuit Health Branch, Alberta Region, Alberta, Canada; Alberta Health and Wellness, Alberta, Canada; National Microbiology Laboratory, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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Daryl Dick Division of Infectious Diseases, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pediatrics, University of Alberta, Alberta, Canada; Provincial Laboratory for Public Health, Edmonton, Alberta, Canada; Division of Infectious Diseases, University of Alberta, Alberta, Canada; First Nations and Inuit Health Branch, Alberta Region, Alberta, Canada; Alberta Health and Wellness, Alberta, Canada; National Microbiology Laboratory, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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Allen Grolla Division of Infectious Diseases, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pediatrics, University of Alberta, Alberta, Canada; Provincial Laboratory for Public Health, Edmonton, Alberta, Canada; Division of Infectious Diseases, University of Alberta, Alberta, Canada; First Nations and Inuit Health Branch, Alberta Region, Alberta, Canada; Alberta Health and Wellness, Alberta, Canada; National Microbiology Laboratory, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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Heinz Feldmann Division of Infectious Diseases, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pediatrics, University of Alberta, Alberta, Canada; Provincial Laboratory for Public Health, Edmonton, Alberta, Canada; Division of Infectious Diseases, University of Alberta, Alberta, Canada; First Nations and Inuit Health Branch, Alberta Region, Alberta, Canada; Alberta Health and Wellness, Alberta, Canada; National Microbiology Laboratory, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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Wadieh Yacoub Division of Infectious Diseases, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pediatrics, University of Alberta, Alberta, Canada; Provincial Laboratory for Public Health, Edmonton, Alberta, Canada; Division of Infectious Diseases, University of Alberta, Alberta, Canada; First Nations and Inuit Health Branch, Alberta Region, Alberta, Canada; Alberta Health and Wellness, Alberta, Canada; National Microbiology Laboratory, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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Karen Grimsrud Division of Infectious Diseases, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pediatrics, University of Alberta, Alberta, Canada; Provincial Laboratory for Public Health, Edmonton, Alberta, Canada; Division of Infectious Diseases, University of Alberta, Alberta, Canada; First Nations and Inuit Health Branch, Alberta Region, Alberta, Canada; Alberta Health and Wellness, Alberta, Canada; National Microbiology Laboratory, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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David Safronetz Division of Infectious Diseases, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pediatrics, University of Alberta, Alberta, Canada; Provincial Laboratory for Public Health, Edmonton, Alberta, Canada; Division of Infectious Diseases, University of Alberta, Alberta, Canada; First Nations and Inuit Health Branch, Alberta Region, Alberta, Canada; Alberta Health and Wellness, Alberta, Canada; National Microbiology Laboratory, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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Robbin Lindsay Division of Infectious Diseases, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Pediatrics, University of Alberta, Alberta, Canada; Provincial Laboratory for Public Health, Edmonton, Alberta, Canada; Division of Infectious Diseases, University of Alberta, Alberta, Canada; First Nations and Inuit Health Branch, Alberta Region, Alberta, Canada; Alberta Health and Wellness, Alberta, Canada; National Microbiology Laboratory, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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In May 2005, a cluster of four hantavirus pulmonary syndrome (HPS) cases was confirmed in Alberta, Canada. The cluster is unusual given that three cases were from a single family and involved a 7-year-old child. This is the first family cluster reported in Canada and includes one of the youngest cases of HPS reported in North America.

Author Notes

Reprint requests: Duncan Webster, Division of Infectious Diseases, St. John Regional Hospital, P.O. Box 2100, St. John, New Brunswick, Canada E2L 4L2, Telephone: 506-648-6807, Fax: 506-648-7379, E-mail: dvwebste@dal.ca.
  • 1

    Nichol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek TG, Feldmann H, Sanchez A, Childs J, Zaki S, Peters CJ, 1993. Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 262 :914–917.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2

    Duchin JS, Koster FT, Peters CJ, Simpson GL, Tempest B, Zaki SR, Ksiazek TG, Rollin PE, Nichol S, Umland ET, Moolenaar RL, Reef SE, Nolte KB, Gallaher MM, Butler JC, Breiman RF, 1994. Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. N Engl J Med 330 :949–1005.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3

    Miedzinski L, 2005. Community-acquired pneumonia: new facets of an old disease—Hantavirus pulmonary syndrome. Respir Care Clin 11 :45–58.

  • 4

    Thacker SB, Wetterhall SF, 1997. Case definitions for infectious conditions under public health surveillance. MMWR Recomm Rep 46 :16.

  • 5

    Padula PJ, Colavecchia SB, Martinez VP, Gonzalez Della Valle MO, Edelstein A, Miguel SDL, Russi J, Mora Riquelme J, Colucci N, Almiron M, Rabinovich RD, 2000. Genetic diversity, distribution and serologic features of hantavirus infection in five countries in South America. J Clin Microbiol 38 :3029–3035.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6

    Pini NC, Resa A, del Jesus Laime G, Lecot G, Ksiazek TG, Levis S, Enria DA, 1998. Hantavirus infection in children in Argentina. Emerg Infect Dis 4 :1–3.

  • 7

    Overturf GD, 2005. Clinical Sin Nombre hantaviral infections in children. Pediatr Infect Dis J 24 :373–374.

  • 8

    Ramos MM, Overturf GD, Crowley MR, Rosenberg RB, Hjelle B, 2001. Infection with Sin Nombre hantavirus: clinical presentation and outcome in children and adolescents. Pediatrics 108 :1–6.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9

    Centers for Disease Control and Prevention, 2006. Case information: Hantavirus pulmonary syndrome case count and descriptive statistics. Available at www.cdc.gov/ncidod/diseases/hanta/hps/noframes/caseinfo.htm. Accessed May 16, 2006.

    • PubMed
    • Export Citation
  • 10

    Ferres M, Vial P, 2004. Hantavirus infection in children. Curr Opin Pediatr 16 :70–75.

  • 11

    Lee BE, Joffe AR, Vaudry W, 1998. Hantavirus pulmonary syndrome: report of the first Canadian paediatric case. Can J Infect Dis 9 :319–321.

  • 12

    Ksiazek TG, Peters JC, Rollin PE, Zaki SR, Nichol S, Spiropoulou C, Morzunov S, Feldmann H, Sanchez A, Khan AS, Mahy BWJ, Wachsmuth K, Butler J, 1995. Identification of a new North American hantavirus that causes acute pulmonary insufficiency. Am J Trop Med Hyg 52 :117–123.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13

    Armstrong LR, Bryan RT, Sarisky J, Khan AS, Rowe T, Ettestad PJ, Cheek JE, Peters CJ, Rollin P, Martin ML, Ksiazek TG, 1995. Mild hantaviral disease caused by Sin Nombre virus in a four-year-old child. Pediatr Infect Dis J 14 :1108–1110.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14

    Allen S, Feddersen R, Foucar K, Hjelle B, James D, Jenison S, Koster F, Levy H, Mertz G, Simpson S, Williams J, Nolte K, Sewell CM, Sands L, Rutherford GW, Hoffman RE, Dixon FR, McFarland L, Damrow TA, DiSalvo A, Shireley LA, Fleming D, Senger KA, Simpson DM, Nichols CR, 1993. Outbreak of hantavirus infection—Southwestern United States 1993. MMWR Morb Mortal Wkly Rep 42 :477–479.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15

    Lindsay LR, Drebot MA, Weiss E, Artsob H, 2001. Hantavirus pulmonary syndrome in Manitoba. Can J Infect Dis 12 :169–173.

  • 16

    Martinez VP, Bellomo C, Juan JS, Pinna D, Forlenza R, Elder M, Padula PJ, 2005. Person-to-person transmission of Andes virus. Emerg Infect Dis 11 :1848–1853.

  • 17

    Lazaro ME, Cantoni GE, Calanni LM, Resa AJ, Herrero ER, Iacono MA, Enria DA, Cappa SMG, 2007. Clusters of hantavirus infection, southern Argentina. Emerg Infect Dis 13 :104–110.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18

    Wells RM, Estani SS, Yadon ZE, Enria D, Padula P, Pini N, Mills JN, Peters CJ, Segura EL, 1997. An unusual hantavirus outbreak in southern Argentina: person-to-person transmission? Emerg Infect Dis 3 :171–174.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19

    Padula PJ, Edelstein A, Miguel SD, Lopez NM, Rossi CM, Rabinovich RD, 1998. Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology 241 :323–330.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20

    Verity R, Prasad E, Grimsrud K, Artsob H, Drebot M, Miedzinski L, Preiksaitis J, 2000. Hantavirus pulmonary syndrome in northern Alberta, Canada: clinical and laboratory findings for 19 cases. Clin Infect Dis 31 :942–946.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21

    Engelthaler DM, Mosley DG, Cheek JE, Levy CE, Komatsu KK, Ettestad P, Davis T, Tanda DT, Miller L, Frampton JW, Porter R, Bryan RT, 1999. Climatic and environmental patterns associated with hantavirus pulmonary syndrome cases in the four corners region. Emerg Infect Dis 5 :87–94.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22

    Mertz GJ, Hjelle BL, Bryan RT, 1997. Hantavirus infection. Adv Intern Med 42 :369–421.

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