Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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A Cluster-Randomized Bovine Intervention Trial against Schistosoma japonicum in the People’s Republic of China: Design and Baseline Results

Darren J. GrayAustralian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; School of Population Health, The University of Queensland, Herston, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, Yueyang, People’s Republic of China; Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, People’s Republic of China; Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai, People’s Republic of China

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Gail M. WilliamsAustralian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; School of Population Health, The University of Queensland, Herston, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, Yueyang, People’s Republic of China; Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, People’s Republic of China; Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai, People’s Republic of China

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Yuesheng LiAustralian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; School of Population Health, The University of Queensland, Herston, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, Yueyang, People’s Republic of China; Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, People’s Republic of China; Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai, People’s Republic of China

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Honggen ChenAustralian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; School of Population Health, The University of Queensland, Herston, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, Yueyang, People’s Republic of China; Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, People’s Republic of China; Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai, People’s Republic of China

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Robert S. LiAustralian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; School of Population Health, The University of Queensland, Herston, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, Yueyang, People’s Republic of China; Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, People’s Republic of China; Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai, People’s Republic of China

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Simon J. ForsythAustralian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; School of Population Health, The University of Queensland, Herston, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, Yueyang, People’s Republic of China; Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, People’s Republic of China; Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai, People’s Republic of China

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Adrian G. BarnettAustralian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; School of Population Health, The University of Queensland, Herston, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, Yueyang, People’s Republic of China; Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, People’s Republic of China; Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai, People’s Republic of China

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Jiagang GuoAustralian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; School of Population Health, The University of Queensland, Herston, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, Yueyang, People’s Republic of China; Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, People’s Republic of China; Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai, People’s Republic of China

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Zheng FengAustralian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; School of Population Health, The University of Queensland, Herston, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, Yueyang, People’s Republic of China; Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, People’s Republic of China; Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai, People’s Republic of China

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Donald P. McManusAustralian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; School of Population Health, The University of Queensland, Herston, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, Yueyang, People’s Republic of China; Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, People’s Republic of China; Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, Shanghai, People’s Republic of China

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DOI:
https://doi.org/10.4269/ajtmh.2007.77.866
Volume/Issue:
Volume 77: Issue 5
Page(s):
866–874
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We describe the design and report baseline results of a cluster-randomized intervention to determine the importance of bovines for Schistosoma japonicum transmission in southern China. The study involves four matched village pairs in Hunan and Jiangxi Provinces, with a village within each pair randomly selected as intervention (human and bovine praziquantel treatment) or control (human praziquantel treatment only). Total study population prevalences at baseline were 12.4% (n = 5,390) and 15.2% (n = 1,573) for humans and bovines, respectively; village prevalences were similar within pairs. Bovine contamination index calculations showed that bovines less than 24 months of age were responsible for 74% of daily bovine environmental contamination with S. japonicum eggs. The village characteristics and baseline results underpin a rigorous study, which has major implications for deployment of a transmission-blocking bovine vaccine against S. japonicum. The combination of such a vaccine with other control strategies could potentially eliminate S. japonicum from southern China.

Copyright:
Copyright 2007 The American Society of Tropical Medicine 2007
Received:
18 Feb 2007
|
Accepted:
19 Jun 2007
|
Published Online:
Nov 2007
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